A study of candida esophagitis in elderly patients attending a district general hospital in the UK

Weerasuriya, N.; Snape, J

doi:10.1111/j.1442-2050.2006.00563.x

Cited by 39 publications

(40 citation statements)

References 12 publications

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“…Even the prevalence of gastro-oesophageal reflux symptoms, a well-known comorbidity with asthma, was shown to be significantly higher in patients with COPD [72], as well as prevalence of faecal incontinence in females aged .40 yrs (OR 1.9) [73] and Candida esophagitis in elderly patients [74].…”

Section: Comorbiditymentioning

confidence: 98%

Definition, epidemiology and natural history of COPD

Viegi¹,

Pistelli²,

Sherrill³

et al. 2007

Eur Respir J

354

268

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Chronic obstructive pulmonary disease (COPD) is the fifth cause of morbidity and mortality in the developed world and represents a substantial economic and social burden. Patients experience a progressive deterioration up to end-stage COPD, characterised by very severe airflow limitation, severely limited and declining performance status with chronic respiratory failure, advanced age, multiple comorbidities and severe systemic manifestations/ complications.COPD is frequently underdiagnosed and under-treated. Today, COPD develops earlier in life and is less gender specific. Tobacco smoking is the major risk factor for COPD, followed by occupation and air pollution. Severe deficiency for a 1 -antitrypsin is rare; several phenotypes are being associated with elevated risk for COPD in the presence of risk factor exposure. Any patient presenting with cough, sputum production or dyspnoea should be assessed by standardised spirometry. Continued exposure to noxious agents promotes a more rapid decline in lung function and increases the risk for repeated exacerbations, eventually leading to end-stage disease.Without major efforts in prevention, there will be an increasing proportion of end-stage patients who can live longer through long-term oxygen therapy and assisted ventilation, but with elevated suffering and huge costs. Smoking prevention and smoking cessation are the most important epidemiological measurements to counteract chronic obstructive pulmonary disease epidemics.

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Section: Comorbiditymentioning

confidence: 98%

Definition, epidemiology and natural history of COPD

Viegi¹,

Pistelli²,

Sherrill³

et al. 2007

Eur Respir J

354

268

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“…These include pharmacological suppression of gastric acid production 1,2,13 , use of antibiotics 24,28 , previous vagotomy 4,7,8 , functional or mechanical esophageal abnormalities 28,30 , and endocrine diseases such as diabetes mellitus, hypothyroidism and hypoparathyroidism 11,18 . Malnutrition, alcoholism, advanced age 26,27,28 , and therapy with corticosteroids -either systemic or inhaled -has also been implicated 2,22 . However, there are very limited data from Brazilian patients.…”

Section: Introductionmentioning

confidence: 99%

Candida esophagitis: species distribution and risk factors for infection

Kliemann

Pasqualotto

Falavigna

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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SUMMARYAlthough Candida albicans is the main cause of fungal esophagitis, other species such as C. tropicalis, C. krusei and C. stellatoidea have also been implicated. Several studies have identified risk factors for C. albicans esophagitis. However, data for non-C. albicans species is still sparse. The aim of this study was to determine the etiology of Candida esophagitis in our medical centre over an 18-month period. Additionally, we aimed to investigate predisposing conditions for esophageal candidosis caused by different Candida species. A total of 21,248 upper gastroscopies were performed in Santa Casa Complexo Hospitalar between January 2005 and July 2006. The prevalence of Candida esophagitis was 0.74% (n = 158). C. albicans caused the vast majority of infections (96.2%), followed by C. tropicalis (2.5%), C. lusitaniae (0.6%) and C. glabrata (0.6%). There were 81 women (51.3%) and 77 men (48.7%). No case of mixed infection occurred. Concomitant oral candidosis was documented for 10.8% (n = 17). Most of cases (55.1%) involved outpatients. Around one fifth of patients in our cohort had no identifiable risk factors for esophageal candidosis (20.8%). Since nearly all infections were caused by C. albicans we were not able to determine risk factors for esophagitis caused by other Candida species.

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“…Age distribution revealed a skewed distribution to the right, indicating that EC in the immunocompetent patient follows an age-related pattern, revealing that EC is much more common in patients above the age of 50 [12]. Another retrospective case-control study of EC in individuals older than 65 years found this condition to be a strong predictor of poor survival in older people irrespective of their functional status [13].…”

Section: Discussionmentioning

confidence: 99%

Esophageal Candidiasis in a Patient With Uncontrolled Diabetes Mellitus and Recurrent Abdominal Pain, Symptomatic Or Incidental? A Case Report and Brief Literature Review

2015

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Esophageal candidiasis (EC) is a common opportunistic infection in patients with impaired cellular immunity, such as human immunodeficiency virus (HIV) infection. However, it can also be found in individuals with certain predisposing conditions like uncontrolled diabetes mellitus (DM) and the use of certain medications. We report a 54-year-old female with past medical history of DM, hypertension and hyperlipidemia who presented to the ER with worsening periumbilical and epigastric pain for 2 days. She had multiple similar presentations requiring admissions to different hospitals and had undergone extensive workup over the past year. She only had transient improvement from these hospitalizations. Esophagogastroduodenoscopy (EGD) performed on day 2 of admission revealed extensive creamy pseudomembranous exudate through the entire length of esophagus confirmed as Candida albicans by brush scraping analysis. She received oral fluconazole with significant relief of her symptoms over the next couple of weeks. Although EC remains asymptomatic in the majority of patients and is only detected incidentally on EGD, its diagnosis and treatment can provide significant symptomatic relief in many patients. EC should be considered as a potential diagnosis in the appropriate clinical setting even in patients with no evidence of overt immunodeficiency.

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A study of candida esophagitis in elderly patients attending a district general hospital in the UK

Cited by 39 publications

References 12 publications

Definition, epidemiology and natural history of COPD

Definition, epidemiology and natural history of COPD

Candida esophagitis: species distribution and risk factors for infection

Esophageal Candidiasis in a Patient With Uncontrolled Diabetes Mellitus and Recurrent Abdominal Pain, Symptomatic Or Incidental? A Case Report and Brief Literature Review

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