A study of childhood psoriasis

Manoharan, R; Thomas, Jayakar; Raneesha, PK; Ragavi, Sindhu; Manoharan, D; Cynthia, S

doi:10.4103/2319-7250.116851

Cited by 4 publications

(3 citation statements)

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“…Such a decrease in rate constant value suggests that N-bromosaccharin is involved in a preequilibrium with some nucleophilic species (probably H 2 O) to form some intermediate with lower reactivity. Similar results were reported in the oxidation of benzhydrols 13 , primary aliphatic alcohols 14 , benzyl alcohol 15 and α-hydroxyl acids [16][17][18] .…”

Section: Dependence Of Rate On Oxidant Concentrationsupporting

confidence: 87%

Micellar Catalysed Kinetic Oxidation Study of Acetophenone by N-Bromosaccharin in Aqueous Acetic Acid Medium

2015

Chem Sci Trans

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The kinetic oxidation study of acetophenone by N-bromosaccharin in aqueous acetic acid medium and in presence of Hg(II) acetate was investigated in the presence of both cationic and anionic micelles. The reaction obeys first order kinetics in oxidant both in the presence as well as absence of micelle. The kinetic results for dependence on substrate concentration indicate intermediate complex formation between oxidant and substrate species. The reactions are acid catalysed and follow both acid dependent and independent path. Change in polarity of the medium, effect of addition of saccharin and Hg(II) acetate have also been investigated. Both type of micelles catalyses the oxidation. Binding parameters have been calculated by analyzing the data using the model suggested by Piszkiewicz. On the basis of kinetic results probable mechanism is proposed. ExperimentalN-Bromosaccharin was prepared by the method suggested by Bacchawat and Mathur 11 and was standardized by iodometric method 12 . Acetophenone (Rhone-Poulene, b.p. 202 °C) solution was prepared by dissolving in glacial acetic acid. The solution of cetyltrimethylammonium bromide (CTAB)-cationic surfactant and sodium lauryl sulphate RESEARCH ARTICLEChem Sci Trans., 2015, 4(4), 890-896 891 (NaLS)-anionic surfactant was prepared by dissolving their appropriate amount in distilled water. Acetic acid (Sd.fine SDS) was first refluxed with chromium trioxide (20 g) and acetic anhydride (20 mL) for 3 h using air condenser. Then it is distilled above 110 °C and distillate was collected. This distillate was used in kinetic studies. Kinetic measurementsKinetic studies were carried out using Ostwald's isolation method. The reaction mixture was equilibrated in a thermosat (±0.1 °C) at desired temperature. The progress of the reaction was monitored by iodometric estimation of unreacted N-bromosaccharin. Stoichiometry and product analysisStoichiometry of the reaction was ascertained by equilibrating the reaction mixture containing an excess of N-bromosaccharin (≈10 times) over the concentration of acetophenone and the concentration of acetic acid and mercuric acetate was maintained at experimental runs. Stoichiometric studies revealed that 1 mol of acetophenone consumed 2 mols of NBSA in the presence as well as absence of surfactant. The stoichiometric equation can be written as:

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Section: Dependence Of Rate On Oxidant Concentrationsupporting

confidence: 87%

Micellar Catalysed Kinetic Oxidation Study of Acetophenone by N-Bromosaccharin in Aqueous Acetic Acid Medium

2015

Chem Sci Trans

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“…Among female children, the youngest patient was 3&1/2 years old. 1 In our case the patient's age at presentation was 2 years. This is the first case to be reported in that age group.…”

Section: Discussionmentioning

confidence: 99%

“…1 Childhood psoriasis is a well-recognized entity, but its true prevalence is still controversial. This chronic disfiguring skin disease in childhood is known to have profound psychological effects and related complications.…”

Section: Introductionmentioning

confidence: 99%

Juvenile psoriasis: a case report

S.Ishwarya

Rajaraman

Bharathi

et al. 2014

Int J Contemp Pediatr

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Ho S Pital Based Study on Childhood Psoriasis

S¹,

S²,

Trishna³

et al. 2015

jemds

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Childhood psoriasis is a distressing condition with significant social and psychological consequences. Childhood psoriasis being a less reported entity, this study was undertaken to study the incidence, pattern and prevalence of childhood psoriasis. MATERIALS & METHODS: In this retrospective epidemiologic study, a complete analysis of OP Records of patients with psoriasis who attended the Psoriasis Clinic of dermatology OPD, during the period of 1 year from June 2014-June 2015 were taken. The age at presentation, duration of psoriasis, pattern of involvement, h/o treatment, h/o preceeding infections were all recorded. RESULTS: The incidence of childhood psoriasis was observed to be (1.16%). The incidence of psoriasis in male (43%) children and female (57%) children. The mean age of onset of childhood psoriasis was (10-14years), positive family history seen in 5% of patients. Psoriasis vulgaris is the most common type of psoriasis followed by palmoplantar psoriasis. Nail involvement was seen in 30% of cases. Arthropathy was seen in 1% of patients. Preceeding infection was seen in 155 of patients. CONCLUSION: The rising trends in incidence of childhood psoriasis in recent times may mirror the evolving lifestyle and psychosocial environment in society. The evolving patterns of childhood psoriasis has significant avenues for research & further follow-up. Larger, coordinated multicentric long term studies to determine their course in adulthood may be required in future.

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A study of childhood psoriasis

Cited by 4 publications

References 1 publication

Micellar Catalysed Kinetic Oxidation Study of Acetophenone by N-Bromosaccharin in Aqueous Acetic Acid Medium

Micellar Catalysed Kinetic Oxidation Study of Acetophenone by N-Bromosaccharin in Aqueous Acetic Acid Medium

Juvenile psoriasis: a case report

Ho S Pital Based Study on Childhood Psoriasis

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