A study of cord blood albumin as a predictor of significant neonatal hyperbilirubinemia in term and preterm neonates

Reshad, Mohamed; Balasundaram, Ravichander; Raghuraman, Thiruchinappalli Subramaniam

doi:10.18203/2320-6012.ijrms20160537

Cited by 13 publications

(19 citation statements)

References 5 publications

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“…67.9% of cases that developed significant neonatal hyperbilirubinemia had cord albumin level 2.8 gm/dl. Burtis et al 17 stated that the lower normal limit for cord serum albumin in term babies was 2.8 gm/dl; and Reshad et al 18 found that in the term group, 19 (61.2%) newborns with cord serum albumin <2.8 g/dl developed neonatal hyperbilirubinemia. Moreover, similar results were reported by several researchers 3,4,19 that found cases with low cord albumin <2.8 gm/dl developed more significant hyperbilirubinemia requiring phototherapy and exchange transfusion.…”

Section: Discussionmentioning

confidence: 99%

Early predictors of neonatal hyperbilirubinemia in full term newborn

Khairy

Abuelhamd

Elhawary

et al. 2019

Pediatrics & Neonatology

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Section: Discussionmentioning

confidence: 99%

Early predictors of neonatal hyperbilirubinemia in full term newborn

Khairy

Abuelhamd

Elhawary

et al. 2019

Pediatrics & Neonatology

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“…[1][2][3] More than two third of the newborn babies develop clinical jaundice. 1,2 Neonatal jaundice can be associated with multiple etiologies, the most common being physiological jaundice.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Neonatal jaundice can be associated with multiple etiologies, the most common being physiological jaundice. 3,4 It is a common practice nowadays that healthy term newborns born by normal vaginal delivery are discharged early because of medical and social reasons and also due to economical constraints.…”

Section: Introductionmentioning

confidence: 99%

“…4,6,9,10 By predicting the newborns developing significant neonatal jaundice early at birth, we can design and implement the follow-up program in high-risk groups effectively and thus prevent kernicterus. 3 1 molecule of Carbon monoxide and 1 molecule of bilirubin is formed by the catabolism of 1 molecule of hemoglobin. Bilirubin is non-polar, insoluble in water and is transported to the liver bound to serum albumin.…”

Section: Introductionmentioning

confidence: 99%

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To study the effectiveness of cord blood Albumin as a predictor of neonatal jaundice

George

Sudhir

2017

Int J Contemp Pediatr

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Background: Neonatal hyperbilirubinemia is one of the commonest problems in newborn. It can be due to different etiologies. Most often it is physiological jaundice. The main reasons for physiological jaundice is that in an infant the liver is not mature enough to handle the freely circulating bilirubin due to higher volume of short life erythrocytes in the circulation and low level of albumin. Early detection of neonatal jaundice is essential to prevent developing kernicterus as well as discharge the babies early. Albumin is synthesized by liver and helps in the transport of unconjugated bilirubin by binding to bilirubin it and thus making it nontoxic to the body. Low levels of albumin make bilirubin free and toxic to the body. Hence, this study was done to evaluate effectiveness of cord blood albumin as a predictor of neonatal Hyperbilirubinemia.Methods: 50 term healthy newborns were included in the study with the term babies of both genders from any mode of delivery, birth weight >2.5 kg, APGAR score more than 7 at 1st and 5th minutes of life and without Rh incapability. Cord blood albumin levels were measured. Blood test for bilirubin was done when required and baby was managed accordingly.Results: Out of the total 50 neonates enrolled, 7 belonged to group 1 (albumin <2.8 g/dl), 34 to group 2 (2.8-3.3 g/dl), and 9 to group 3 (>3.3 g/dl). Out of the total 7 neonates in group 1, 6 (85.71%) was icteric at 24-48 hours and 1 (14.29%) was icteric at >72 hours. All the 7 neonates developed Hyperbilirubinemia requiring phototherapy. 3 (42.86%) out the 7-neonate required phototherapy for more than 24 hours. Out of the total 34 neonates in group 2, 20 (58.82%) was icteric at >72 hours, 12 (35.29%) at 48-72 hours and 2 (5.88%) at 24-48 hours. Only 12 (35.29%) neonates had Hyperbilirubinemia requiring phototherapy. Out of the total 9 neonates in group 3, 1 was icteric at 48 - 72 hours and 8 was icteric at >72 hours. But only 2 had Hyperbilirubinemia requiring phototherapy.Conclusions: Cord blood albumin is an effective way to predict neonatal Hyperbilirubinemia in term healthy infants.

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“…Clinical jaundice is found in about 80% of preterm and in about 60-70% of term neonates [2]. More than 6.1% of term neonates were found to have bilirubin level more than 12.9 mg/dl and 3% of term neonates had bilirubin level more than 15 mg/dl [3]. In India incidence of neonatal hyper bilirubinemia varied from 4.3% to 6.5% of all live born babies [4].…”

Section: Introductionmentioning

confidence: 99%

Cord serum albumin as a predictor of neonatal hyper bilirubinemia in healthy full-term neonates

et al. 2018

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Introduction: Neonatal jaundice or icterus neonatorum is one of the common problem that is seen in newborns during first week of neonatal life. Clinical jaundice is found in about 80% of preterm and in about 60-70% of term neonates. The main objective of the study was to determine the correlation between cord serum albumin levels and development of significant hyper bilirubinemia in healthy term neonates. Methods: A prospective study was conducted on 316 healthy term neonates. Gender, mode of delivery and birth weight were taken into consideration. It was ascertained that there was no other risk factor for neonatal hyperbilirubinemia among these newborns. These neonates were divided into 3 groups, Group A (cord serum albumin levels < 2.8 gm/dl), Group B (cord serum albumin levels between 2.8 to 3.4 gm/dl) and Group C (cord serum albumin levels > 3.4 gm/dl). Result: Of the 316 babies included in the study, 102 babies were under Group A, 166 babies under Group B and 48 babies under Group C. 35 babies in Group A, 5 in Group B and none in Group C developed significant hyperbilirubinemia and required phototherapy. The sensitivity and specificity of cord serum albumin level < 2.8 g/dl to predict risk of development of significant neonatal hyperbilirubinemia in our study was 87.50% and 75.72% respectively. Conclusion: Cord serum albumin levels can help us to predict the possibility of significant hyperbilirubinemia among neonates. Hence this can help us to identify the at-risk neonates and utilize our limited resources efficiently among these newborns.

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A study of cord blood albumin as a predictor of significant neonatal hyperbilirubinemia in term and preterm neonates

Cited by 13 publications

References 5 publications

Early predictors of neonatal hyperbilirubinemia in full term newborn

Early predictors of neonatal hyperbilirubinemia in full term newborn

To study the effectiveness of cord blood Albumin as a predictor of neonatal jaundice

Cord serum albumin as a predictor of neonatal hyper bilirubinemia in healthy full-term neonates

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