2010
DOI: 10.1016/j.ejmech.2010.05.069
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A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities☆

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Cited by 88 publications
(60 citation statements)
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“…These compounds demonstrated significant anticonvulsant activities in vivo against maximal electroshock (MES)-and subcutaneous pentylenetetrazole (scPTZ)-induced seizure tests. Also, in our recent studies Mannich bases of chlorokojic acid (route B) exhibited good antimicrobial and antiviral activities [10][11] . Therefore in present work we planned to synthesize eighteen novel 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one derivatives including piperazine ring and evaluate for their anticonvulsant and antimicrobial couplet with antitubercular activities (Scheme 2).…”
Section: Research Articlementioning
confidence: 99%
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“…These compounds demonstrated significant anticonvulsant activities in vivo against maximal electroshock (MES)-and subcutaneous pentylenetetrazole (scPTZ)-induced seizure tests. Also, in our recent studies Mannich bases of chlorokojic acid (route B) exhibited good antimicrobial and antiviral activities [10][11] . Therefore in present work we planned to synthesize eighteen novel 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one derivatives including piperazine ring and evaluate for their anticonvulsant and antimicrobial couplet with antitubercular activities (Scheme 2).…”
Section: Research Articlementioning
confidence: 99%
“…In our laboratory, a large number of Mannich bases of kojic acid (route A), chlorokojic acid (route B), and allomaltol (route C) were prepared (Scheme 1) for their various types of biological activities 4,[6][7][8][9][10][11] . Most of these compounds seemed to be promising candidates for anticonvulsant, antimicrobial and antiviral agents.…”
Section: Research Articlementioning
confidence: 99%
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“…Benzhydrylpiperazine scaffold is well known for its antihistaminic activity [6][7][8][9][10][11] . Furthermore calcium channel blocking [12][13][14][15][16][17][18][19] , dopaminergic [20][21][22][23] , antimicrobial [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] and antiviral 42,43 activities are often mentioned in literature.…”
Section: Introductionmentioning
confidence: 99%