A study of dengue fever in pregnancy and its maternal and fetal prognosis

Gehlot, Hanslata; Yadav, Om Prakash; Sharma, Seema; Nagar, Girdhar Gopal; Yadav, A. K.; Gupta, Priti

doi:10.18203/2320-1770.ijrcog20173454

Cited by 10 publications

(10 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As expected, four patients closer to their expected date of delivery had more severe clinical symptoms and landed up in multiorgan failure. [1] Most common symptoms included fever with chills(92%),followed by myalgia(80%) and arthralgia similar to other studies. [8] Though 76% of patients tested positive for NS1Ag which is highest among our patients, not all of them tested positive but 24% of patients tested positive only for IgM Antibodies, suggesting that the patients had recent infection with ending of viremic phase.…”

Section: Discussionsupporting

confidence: 85%

See 1 more Smart Citation

Could Serological Markers of the Dengue Viral Disease Predict the Outcomes in Pregnant South Asian Population?

Guruprasad¹,

Rachakonda²,

Mande³

2020

IJISRT

View full text Add to dashboard Cite

A recent rise in the incidence of a vector borne viral disease, Dengue Disease, in South Asian countries has also shown an impact on the pregnant population in these regions. There are four known Dengue virus serotypes, the predominant ones being DENV- 2 and DENV-3, when present during pregnancy could be associated with complications like preterm birth, maternal mortality and morbidity and adverse neonatal outcomes.[1]. We aimed to study the outcomes in the pregnant patients that presented to our institution with the Dengue disease.  Methods: A 6-month (1/9/2019 – 29/2/2020) study was undertaken during the months of high prevalence of the Dengue disease in our region. Clinical, laboratory, maternal and foetal outcomes were studied among serologically positive dengue mothers treated at MGM Hospital, Aurangabad. A total of 25 patients were found to have Dengue disease during the study period. NS1Ag and IGM serological analysis results were used to achieve diagnosis and early management. 7 patients had symptomatic thrombocytopenia and needed platelet transfusions. Majority of our patients had favourable outcomes. 3 mothers died succumbing to the multiorgan failure. Favourable maternal and foetal outcomes could be achieved with early diagnosis of suspected Dengue disease with both NS1Ag and IGM serological analysis.

show abstract

Section: Discussionsupporting

confidence: 85%

“…The four serotypes designated as DENV -1, DENV -2, DENV -3, DENV -4. [1] It is one of the most important vector borne diseases affecting countries like India, with the vector being the Aedes aegyptis mosquito. 40% of the world's population live in dengue prone zone, indicating the high risk and burden of carrying the disease.…”

Section: Introductionmentioning

confidence: 99%

Could Serological Markers of the Dengue Viral Disease Predict the Outcomes in Pregnant South Asian Population?

Guruprasad¹,

Rachakonda²,

Mande³

2020

IJISRT

View full text Add to dashboard Cite

show abstract

“…A useful finding of our study was the predictive value of ocular findings in the diagnosis of dengue in our pregnant cohort. A separate study of pregnant women with dengue in northern India reported similar findings: 100% of the dengue patients had conjunctivitis, and 57% had eye pain (30). According to the World Health Organization, dengue should be considered in patients with a high fever and retroorbital pain (31)(32)(33)(34), but there is no specific mention of conjunctivitis as a trigger for dengue testing.…”

Section: Discussionmentioning

confidence: 96%

Intensified Short Symptom Screening Program for Dengue Infection during Pregnancy, India

Naik

Robinson²,

Alexander³

et al. 2020

Emerg. Infect. Dis.

View full text Add to dashboard Cite

E very year, an estimated 96 million persons worldwide are given a clinical diagnosis of severe dengue infection (1). In 2017, a total of 188,401 cases of dengue were diagnosed in India, and the mortality rate was 0.1%. The mortality rate in Maharashtra State was 0.8% in 2017, nearly 8 times higher than the national average (2,3). The prevalence of dengue infection among pregnant women is not reported, but pregnant women may be uniquely susceptible to dengue infection because of the immune changes that occur during pregnancy (4). In some countries in Southeast Asia, dengue fever is the most common cause of acute febrile illness during pregnancy (5). Dengue infection during pregnancy has been associated with poor maternal and infant outcomes, including preterm birth (6), hemorrhage, preeclampsia, and caesarean delivery (7-15). Dengue virus can also be vertically transmitted to the infant, resulting in neonatal dengue, thrombocytopenia, and cerebral hemorrhage (16-19). Vertical transmission is most likely if the infection occurs in the third trimester or is present during delivery by cesarean section (20). Despite the devastating consequences, the diagnosis of dengue infection during pregnancy remains challenging. This challenge is partially caused by overlapping signs and symptoms of dengue infection with other conditions, such as HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome, pneumonia, pulmonary embolism, and other febrile illnesses (21,22). Moreover, molecular assays to diagnose dengue are not widely available. However, there is a remarkable reduction in the case-fatality rate after early diagnosis and access to appropriate medical care (23). This study was planned after detection of Zika virus in India. The goal of this study was to determine the prevalence of dengue, chikungunya, and Zika virus among pregnant women in Pune, India. We also aimed to identify clinical predictors of these infections to improve screening and detection during the antenatal setting. Methods Ethics This study was approved by the Byramjee Jeejeebhoy Medical College Clinical Trials Unit and Johns

show abstract

“…The average birth weight noted in our study was 2.44kgs. Gehlot H et al 9 reported an average birth weight of <2.5 kg in 16% cases. 8% of babies required NICU admission and 4% had IUFD.…”

Section: Discussionmentioning

confidence: 97%

The spectrum of dengue fever in pregnancy

2020

IJOGR

View full text Add to dashboard Cite

Introduction: Dengue is a vector-borne disease transmitted by the mosquito Aedes aegypticus. Dengue infection in pregnancy carries the risk of hemorrhage for both the mother and the newborn. Materials and Methods: 148 patients with acute febrile illness during Nov 2015 to Nov 2017 were analysed. Data regarding course of illness, lab reports which included complete blood count, urine routine and culture, NS1 Antigen, WIDAL and Peripheral smear for malarial parasite, treatment received, maternal and perinatal outcome were analysed from records. Results: NS1 Antigen was detected in 40% of all cases with fever. Amongst the remaining, 15% had viral fever, 14% had urinary tract infection, 10% had enteric fever, 8% had lower respiratory tract infection, 2% had malaria and 9% had fever of unknown origin. Thrombocytopenia was present in 40% of dengue positive patients and 30% of patients required transfusion. 2 patients diagnosed close to term had postpartum hemorrhage treated with platelets and FFPs. There were two neonatal deaths. Conclusion:Though most cases required only conservative management one has to keep in mind the correlation of period of gestation to the outcome and complications.

show abstract

A study of dengue fever in pregnancy and its maternal and fetal prognosis

Cited by 10 publications

References 3 publications

Could Serological Markers of the Dengue Viral Disease Predict the Outcomes in Pregnant South Asian Population?

Could Serological Markers of the Dengue Viral Disease Predict the Outcomes in Pregnant South Asian Population?

Intensified Short Symptom Screening Program for Dengue Infection during Pregnancy, India

The spectrum of dengue fever in pregnancy

Contact Info

Product

Resources

About