A Study of Differences in Penile Dorsal Nerve Somatosensory Evoked Potential Testing Among Healthy Controls and Patients With Primary and Secondary Premature Ejaculation

Sun, Zhaohui; Liao, Zedong; Zheng, Qi-Gang; Chen, Jiajian; Lv, Bodong; Bao, Chunxiang; Huang, Xiaojun

doi:10.1016/j.jsxm.2021.01.186

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…Pudendal somatosensory evoked potentials are an examination to assess pelvic floor function by recording scalp Cz-2 area potentials and calculating P41 wave latency and wave amplitude [ 26 ]. Given the sex differences, the patients in the two groups were further subgrouped by sex, and the results of the present study showed that in both males and females, the latency of the left and right bulbocavernosus muscle reflexes in the case group was longer than in the control group, but the difference was not statistically significant, and the wave amplitude of the left and right bulbocavernosus muscle reflexes was significantly smaller than that of the control group, which may be attributable to the predominance of axonal damage in the pubic neuropathy in patients with diabetic neurogenic bladder, which is consistent with the results of previous research [ 27 ], and patients with neurogenic bladder showed more severe pubic neuropathy and vesicourethral dysfunction compared to those without neurogenic bladder. The bulbocavernosus reflex is caused by stimulation of the dorsal nerve of the penis and the efferent nerve via the sacral medullary S2 to S4 reflex arc, causing contraction of the bulbocavernosus and sciatic cavernosus muscles.…”

Section: Discussionsupporting

confidence: 90%

To Explore the Diagnostic Value of Bulbocavernosus Muscle Reflex and Pudendal Somatosensory Evoked Potentials for Diabetic Neurogenic Bladder

2022

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Objective. To explore the diagnostic value of bulbocavernosus muscle reflex and pudendal somatosensory evoked potentials for diabetic neurogenic bladder. Methods. From January 2021 to December 2021, 104 patients with type 2 diabetes mellitus admitted to the hospital were recruited, with 57 allocated to the case group and 47 to the control group. Outcome measures included bulbocavernosus muscle response, pudendal somatosensory evoked potentials, and bladder residual urine volume. The connection of bulbocavernosus muscle response and pudendal somatosensory evoked potentials with bladder residual urine volume was investigated using the Pearson analysis. Results. In both males and females, the latency of the left and right bulbocavernosus muscle reflexes in the case group was longer than in the control group, but the difference was not statistically significant ( P > 0.05 ), and the wave amplitude of the left and right bulbocavernosus muscle reflexes was significantly smaller than that of the control group ( P < 0.05 ). The diabetic neurogenic bladder was associated with a significantly longer latency and a smaller wave amplitude of pudendal somatosensory evoked potentials versus without neurogenic bladder ( P < 0.05 ). Patients with a diabetic neurogenic bladder had more residual bladder urine volume versus those without ( P < 0.05 ). Bladder residual urine volume was significantly positively correlated with bulbocavernosus muscle reflex and pudendal somatosensory evoked potential latency and negatively correlated with wave amplitude ( P < 0.05 ). Conclusion. The bulbocavernosus muscle reflex and pudendal somatosensory evoked potentials demonstrate great potential as adjuncts to diagnose diabetic neurogenic bladder and correlate with ultrasound results in determining bladder function in patients.

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Section: Discussionsupporting

confidence: 90%

To Explore the Diagnostic Value of Bulbocavernosus Muscle Reflex and Pudendal Somatosensory Evoked Potentials for Diabetic Neurogenic Bladder

2022

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“…PE‐related genetic polymorphisms in lifelong PE patients are also different from those in normal men (Janssen et al, 2009; Santtila et al, 2010). A recent study focused on penile dorsal nerve somatosensory‐evoked potential and found intergroup differences between patients with pPE and patients with aPE (Sun et al, 2021). These studies demonstrate the innate characteristics of pPE.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety assessment of glandular augmentation with hyaluronic acid for premature ejaculation

et al. 2022

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Glandular augmentation (GA) with hyaluronic acid (HA) is a newly developed, minimally invasive therapy for patients with premature ejaculation (PE); however, evidence supporting its efficacy is scarce. To provide a comprehensive profile of GA with HA gel in managing PE, 184 patients with PE who received GA with HA gel therapy from October 2017 to November 2019 were included and followed up for 1 year. The Fan technique was applied. Intravaginal Ejaculation Latency Time (IELT), Chinese Index of Premature Ejaculation‐5(CIPE‐5) and Visualised Satisfaction Index (VSI) of sexual experience were assessed at initial and 1‐, 3‐, 6‐ and 12‐month post injection. A total of 71 patients with primary PE (pPE, 38.6%) and 113 patients with acquired PE (aPE, 61.4%) were enrolled. The mean IELT increased to 100.7 ± 43.2 s(p < .05) for pPE patients and 359.2 ± 87.1 s (p < .05) for aPE patients 1‐month post injection and remained significantly higher at the end point with acceptable attenuation. The mean CIPE‐5 score increased to 17.6 ± 6.4 (p < .05) in the 1st month and remained steady. The VSI scores increased to 6.6 ± 1.0 (p < .05) for patients with pPE and 7.7 ± 1.2 (p < .01) for patients with aPE. Increments in VSI in patients with aPE were significantly higher than those in patients with pPE (p < .01). No severe complications were noted. GA with HA may be an effective and safe method to treat PE. Patients with acquired PE were also more satisfied post treatment.

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“…Somatosensory evoked potentials (SSEPs) have been recognized in recent years as an objective and effective method to measure penile sensitivity in PE. 7 …”

Section: Introductionmentioning

confidence: 99%

The sensitivity difference between the glans penis and penile shaft in primary premature ejaculation

Jiang

et al. 2023

Asian Journal of Andrology

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The penis is a vital organ of perception that transmits perceived signals to ejaculation-related centers. The penis consists of the glans penis and penile shaft, which differ considerably in both histology and innervation. This paper aims to investigate whether the glans penis or the penile shaft is the main source of sensory signals from the penis and whether penile hypersensitivity affects the whole organ or only part of it. The thresholds, latencies, and amplitudes of somatosensory evoked potentials (SSEPs) were recorded in 290 individuals with primary premature ejaculation using the glans penis and penile shaft as the sensory areas. The thresholds, latencies, and amplitudes of SSEPs from the glans penis and penile shaft in patients were significantly different (all P < 0.0001). The latency of the glans penis or penile shaft was shorter than average (indicating hypersensitivity) in 141 (48.6%) cases, of which 50 (35.5%) cases were sensitive in both the glans penis and penile shaft, 14 (9.9%) cases were sensitive in the glans penis only, and 77 (54.6%) cases were sensitive in the penile shaft only (P < 0.0001). There are statistical differences in the signals perceived through the glans penis and the penile shaft. Penile hypersensitivity does not necessarily mean that the whole penis is hypersensitive. We classify penile hypersensitivity into three categories, namely, glans penis, penile shaft, and whole-penis hypersensitivity, and we propose the new concept of penile hypersensitive zone.

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A Study of Differences in Penile Dorsal Nerve Somatosensory Evoked Potential Testing Among Healthy Controls and Patients With Primary and Secondary Premature Ejaculation

Cited by 6 publications

References 12 publications

To Explore the Diagnostic Value of Bulbocavernosus Muscle Reflex and Pudendal Somatosensory Evoked Potentials for Diabetic Neurogenic Bladder

To Explore the Diagnostic Value of Bulbocavernosus Muscle Reflex and Pudendal Somatosensory Evoked Potentials for Diabetic Neurogenic Bladder

Efficacy and safety assessment of glandular augmentation with hyaluronic acid for premature ejaculation

The sensitivity difference between the glans penis and penile shaft in primary premature ejaculation

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