A study of disseminated intravascular coagulation in acute leukemia reveals markedly elevated D‐dimer levels are a sensitive indicator of acute promyelocytic leukemia

Abstract

Overall we identify elevated D-dimer concentrations ≥19 000 ng/mL FEU are a sensitive indicator of acute promyelocytic leukemia (APL), with a sensitivity of 96% and specificity of 92% in the subtyping of acute leukemias, and that the presence of schistocytes in peripheral blood smears is not a diagnostically sensitive screening test for DIC with a sensitivity of 36%.

Management of hemostatic complications in acute leukemia: Guidance from the SSC of the ISTH

“…Table 1 summarizes studies of DIC in acute leukemia. 22,[24][25][26][27][28][29][30][31][32][33][34][35][36][37] The majority of the studies were small, single-center and retrospective, and often without a standardized protocol for evaluation of DIC.…”

“…The incidence of DIC varies widely in published studies, although APL has the highest risk with a reported incidence of 70% to 80%. Table 1 summarizes studies of DIC in acute leukemia 22,24‐37 . The majority of the studies were small, single‐center and retrospective, and often without a standardized protocol for evaluation of DIC.…”

Coagulación intravascular diseminada

“…La CID se asocia con mayor frecuencia a infección sistémica o inflamación y, por lo tanto, se asocia a sepsis, traumatismos, neoplasias y trastornos inmunodeficientes 11 . La CID Implica la evaluación de parámetros de coagulación incluyendo niveles de Dímero D(D-D), Tiempo Parcial de Tromboplastina (TPT), Tiempo de Protrombina(TP), concentración de fibrinógeno y recuentos de plaquetas 13 . La morfología de glóbulos rojos en un frotis de sangre periférica se evalúa frecuentemente para evaluar esquistocitos, como característica morfológica útil que puede estar presente en CID 13 .…”

Blood Parameters in Treatment with Arsenic Trioxide in Acute Promyelocytic Leukemia: A Systematic Review

“…International Journal of Hematology Oncology and Stem Cell Research ijhoscr.tums.ac.ir hemorrhagic disorder forms are disseminated intravascular coagulation (DIC), thrombosis and bleeding 8,9,10 . Tissue factor releasing from the APL cells is considered to be the most important reason for the coagulopathy.…”

“…In these events, evaluations of some factors are necessary to be done (i.e. D-dimer level, Prothrombin time, Thrombin time, Fibrinogen concentration) 8 . Different types of therapies could be done to restrict the progression of APL disease.…”