A Study of Early Pregnancy Factor Activity in the Sera of Women with Trophoblastic Tumor

Abstract

PROBLEM: To detect whether or not the early pregnancy factor (EPF)‐like activity, or chaperonin 10, could be in the sera of patients with trophoblastic tumor in order to find another more efficient means to diagnose this kind of tumor. METHOD OF STUDY: The rosette inhibition assay was used to detect EPF‐like activity in 216 sera, collected from patients with gestational trophoblastic tumor, including 47 sera of patients with choriocarcinoma, 68 sera of patients bearing invasive mole, and 101 sera of patients with vesicular mole. RESULTS: The accuracy of diagnosing malignant trophoblastic tumor by detecting EPF‐like activity is 91.3% (105/115), with a false positive rate of 14.58% and a false negative rate of 4.48% by this method. Furthermore, the rosette inhibition titer (RIT) values have significant difference (P < 0.001) between the sera in patients with malignant trophoblastic tumor before treatment and those after treatment. CONCLUSIONS: This study demonstrated that diagnosis of malignant trophoblastic tumor could be made with an accuracy of 91.3%) by detecting EPF‐like activity and that EPF‐like activity could be used as an indicator to distinguish benign from malignant trophoblastic tumor.

Proteomic Biomarkers for the Detection of Endometrial Cancer

“…It is postulated that physio-pathological features of the tumour microenvironment including changes in oxygen concentration, pH and glucose levels propagate Hsp induction [91]. Regardless of the mechanism underpinning their oncogenic tendency, their potential as EC diagnostic biomarkers is limited by their non-specificity (Table 2) [95,97,98]. In combination with other proteins, however, they are likely to be strong candidates for EC detection and warrant further exploration.…”