1967
DOI: 10.1016/0014-4827(67)90370-9
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A study of erythropoiesis in the rat

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Cited by 36 publications
(21 citation statements)
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“…After 10 weeks of irradiation or 6 weeks of phenylhydrazine treatment, each rat was injected intravenously with IOO PCi "Fe (specific activity z Ci per g. Fe), and 10 mg. of non-radioactive iron ('Ferrivenin') administered 4 hours later in order to suppress the utilization of stored "Fe. The animals were sacrificed at 3-hour intervals, and preparations made for blood and bone marrow autoradiographs, as previously described (Tarbutt, 1967a).…”
Section: S Fe Autoradiographymentioning
confidence: 99%
“…After 10 weeks of irradiation or 6 weeks of phenylhydrazine treatment, each rat was injected intravenously with IOO PCi "Fe (specific activity z Ci per g. Fe), and 10 mg. of non-radioactive iron ('Ferrivenin') administered 4 hours later in order to suppress the utilization of stored "Fe. The animals were sacrificed at 3-hour intervals, and preparations made for blood and bone marrow autoradiographs, as previously described (Tarbutt, 1967a).…”
Section: S Fe Autoradiographymentioning
confidence: 99%
“…It is rather surprising that fi broblasts in cell cultures take up such large amounts of iron, as in vivo iron turnover in such tissues is so small that ferrokinetic measurements cannot detect it [2]. Similar observations are made for lymphoid cells, as lymphoblasts in culture [this paper] and phytohemagglutinin-stimulated lymphocytes [32] take up significant amounts of iron, whereas iron up take in vivo by lymphoid cells could not be observed [36]. Probably, iron requirement is related to the rate at which cells divide.…”
Section: Discussionmentioning
confidence: 62%
“…Inversely, in the rat the polychromatic normoblast represents the most active element, and circulating reticulocytes still take up iron [4,[12][13][14]. As shown by radioautography, iron uptake is highest at the pronormoblast stage in man, declining thereafter, and ceasing in the marrow reticuloc yte [ 1, 1 1 ].…”
Section: Resultsmentioning
confidence: 99%