A Study of Gastric Secretion as Influenced by Changes in Duodenal Acidity

Effect of acid in the duodenum on histamine-stimulated gastric secretion in man

“…Many workers have also observed inhibition of gastric secretion when acid is placed in the duodenum in dogs (Sokolov, 1904;Day and Webster, 1935;Pincus, Thomas, and Rehfuss, 1942;Code and Watkinson, 1955;Jones and Harkins, 1959;Andersson, 1960a and b;Andersson and Uvnas, 1961). However, in man the evidence is not so uniform.…”

Importance of vagal innervation in the regulatory effect of acid in the duodenum on gastric secretion of acid

“…Conflicting results have been obtained by those who have worked subsequently on this problem, significant inhibition being obtained in canine and human studies by some observers (Day & Webster, 1935;Griffiths, 1936; Wilhelmj, McCarthy & Hill, 1937;Shay, Gershon-Cohen & Fels, 1942), whereas others have been unable to confirm the effect (Stevens, Segal & Scott, 1939;Woodward, Lyon, Landor & Dragstedt, 1954). A valuable contribution was that of Pincus and his co-workers (Pincus, Thomas & Rehfuss, 1942;Pincus, Friedman, Thomas & Rehfuss, 1944), who demonstrated that a critical intraduodenal pH was necessary to elicit inhibition, and concluded that this finding was the likely explanation for the conflicting results. However, the mechanism of the inhibition and the types of secretion consistently inhibited by acid have remained in doubt.…”