A Study of Glucagon Isolated Vascular Preparations

Mishra, Sanjeev; Sharma, Akash; Kishore, Sanjeev

doi:10.1016/b978-0-08-021308-8.51081-4

Cited by 1 publication

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“…It has been found to reduce resistance (Bashour, Geumei, Nagrawi & Downey, 1973) and reduce the constrictor effects of noradrenaline, angiotensin and vasopressin (Richardson & Withrington, 1975) in the dog hepatic vasculature possibly by increasing extracellular potassium concentration (Hulstaert, Beijer, Brouwer, Teunissen & Charbon, 1974). Recent findings suggest a similar action in the rat mesenteric arteries but no such effect even at high concentrations was seen in the rat hindlimb vessels (Mishra, Sharma & Kishore, 1975). Hyperglucagonaemia may, therefore, contribute to the decreased noradrenaline pressor responses seen in the fed diabetic groups and account for the contrast between these results and those of the perfused rat hindquarter preparation.…”

Section: Discussionmentioning

confidence: 99%

Effect of Experimental Diabetes, Food Deprivation and Genetic Obesity on the Sensitivity of Pithed Rats to Autonomic Agents

Foy

Lucas

1976

British J Pharmacology

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I The sensitivities of alloxan and streptozotocin diabetic and hereditary obese pithed rats to acetylcholine, isoprenaline and noradrenaline were compared to those of controls. 2 Blood pressure and heart rate recordings made before dosing was started showed the streptozotocin-treated animals to have a significantly reduced heart rate and increased pulse pressure as compared with controls.3 Both diabetic groups were found to have reduced sensitivities to the pressor effect of noradrenaline, the depressor effect of acetylcholine, the positive chronotropic and inotropic effect of isoprenaline and the reduction in diastolic pressure induced by isoprenaline. The reduction in sensitivity was generally much greater in the streptozotocin diabetic animals. 4 The genetically obese rats were found to have similar sensitivities to all three agents as did their non-obese litter mates. 5When either diabetic group was deprived of food for 24 h preceding the tests the sensitivities were found to be raised significantly towards normal in almost all cases. 6 The results are contrasted with previous in vitro results and possible causative metabolic factors discussed. It is suggested that sensitivity changes are unevenly distributed within the cardiovascular system.

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Section: Discussionmentioning

confidence: 99%