A study of highly sensitive surface plasmon resonance biosensor for the detection of SARS-CoV-2 virus

Yadav, Prateek Kumar; Upadhyay, Satyam; Kumar, Anil; Kumar, Awadhesh; Chaurasia, Rameshwar Nath; Srivastava, S. K.

doi:10.1007/s11082-024-07586-y

Opt Quant Electron

2024

DOI: 10.1007/s11082-024-07586-y

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A study of highly sensitive surface plasmon resonance biosensor for the detection of SARS-CoV-2 virus

Prateek Kumar Yadav,

Satyam Upadhyay,

Anil Kumar

et al.

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2024

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Cited by 2 publications

References 56 publications

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SARS-CoV-2 detection by surface plasmon resonance biosensors based on graphene-multilayer structures

Tene,

Guevara,

Romero

et al. 2024

Front. Phys.

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The COVID-19 pandemic has created a demanding need for fast, sensitive, and reliable diagnostic methods to identify viral infections like SARS-CoV-2. In response, surface plasmon resonance (SPR) biosensors have emerged as effective tools for detecting biomolecules. This theoretical study focuses on designing and refining multilayer SPR biosensor configuration to ensure high sensitivity and stability. The optimized configuration consists of a thin silver layer, a silicon nitride layer, a single graphene layer, and a ssDNA bioreceptor layer, each tailored to improve the effectiveness of the proposed biosensor. The capability of the biosensor to detect SARS-CoV-2 is assessed by analyzing its SPR response, specifically examining variations in resonance angle, attenuation, full width at half maximum, and sensitivity across a range of viral concentrations. Additionally, this study evaluated performance metrics such as refractive index sensitivity, detection accuracy, and quality factor to determine the effectiveness of the biosensor against SARS-CoV-2. Then, this work establishes a basis for further development of SPR biosensors aimed at various viral and biomolecular targets, supporting advances in biosensing technology and the creation of effective diagnostic tools to address current and future health challenges.

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SARS-CoV-2 detection by surface plasmon resonance biosensors based on graphene-multilayer structures

Tene,

Guevara,

Romero

et al. 2024

Front. Phys.

View full text Add to dashboard Cite

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Widening of Dynamic Detection Range in Real-Time Angular-Interrogation Surface Plasmon Resonance Biosensor Based on Anisotropic Van Der Waals Heterojunction

Yu,

Ouyang,

et al. 2024

Biosensors

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Surface plasmon resonance (SPR) biosensors have experienced rapid development in recent years and have been widely applied in various fields. Angular-interrogation SPR biosensors play an important role in the field of biological detection due to their advantages of reliable results and high stability. However, angular-interrogation SPR biosensors also suffer from low detection sensitivity, poor real-time performance, and limited dynamic detection range, which seriously restricts their application and promotion. Therefore, we designed an angular-interrogation SPR biosensor based on black phosphorus (BP)/graphene two-dimensional (2D) van der Waals heterojunction (vdWhs). On the basis of using the angle-fixed method, this biosensor not only has good real-time performance but also detection sensitivity enhancement. The optical anisotropy characteristic of BP is used to widen the dynamic detection range of biosensors. The simulation results show that the maximum detection sensitivity of the proposed biosensor is 258.6 deg/RIU. Compared with the bare-Ag film structure biosensor, the detection sensitivity was enhanced by 209.2% by 2D vdWhs. The use of anisotropic 2D material BP can not only enhance the detection sensitivity but also widen the detection range. When the fixed incident angle is θ = 5 deg, a maximum dynamic detection range enhanced factor of 123.1% can be achieved, and a detection sensitivity of 185.2 deg/RIU in the corresponding interval can be obtained. The proposed biosensor in this study has potential broad application prospects in several fields, such as biological detection.

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A study of highly sensitive surface plasmon resonance biosensor for the detection of SARS-CoV-2 virus

Cited by 2 publications

References 56 publications

SARS-CoV-2 detection by surface plasmon resonance biosensors based on graphene-multilayer structures

SARS-CoV-2 detection by surface plasmon resonance biosensors based on graphene-multilayer structures

Widening of Dynamic Detection Range in Real-Time Angular-Interrogation Surface Plasmon Resonance Biosensor Based on Anisotropic Van Der Waals Heterojunction

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