A study of histopathological features of medullary carcinoma of the thyroid: Cases from a single institute in India

Desai, Saral; Sarkar, S; Borges, Anita M.

doi:10.4103/0019-509x.15096

Cited by 23 publications

(25 citation statements)

References 11 publications

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“…The majority of patients diagnosed with MTC presented with thyroid gland enlargement, as found in previous publications [17][18][19][20]. In this current study, 27.3% of the patients with MTC had nodal involvement at histological diagnosis.…”

Section: Discussionsupporting

confidence: 67%

“…This finding differs from those reported by Saral et al, [17] who found the disease to be twice as common in men as in women. This finding is also different from the studies of Sipple et al, [12] and Williams et al, [13] that found female predominance, but similar to the study of Grubbs et al, [18] that found no difference in incidence doi: 10.7243/2052-7896-5-1 bet-ween males and females.…”

Section: Discussioncontrasting

confidence: 57%

“…Although the study did not categorise patients into hereditary and sporadic forms of MTC, this value is closer to the mean age of 38.0 years previously reported by Kebebew et al, [16] who did not group their patients into the two forms. Furthermore, the current mean age of patients with MTCs lies between the mean age of 35.0 years for familial variant [6] and 46.7 years for patients with sporadic variant [13,17].…”

Section: Discussionmentioning

confidence: 99%

“…MTC may show slight female preponderance [12,13], one study found male preponderance [17], while Grubbs et al, [18] found no sex differences. The commonest clinical presentation of MTC doi: 10.7243/2052-7896-5-1 from previous studies is an enlarged thyroid gland, especially at the poles [19,20].…”

Section: Introductionmentioning

confidence: 97%

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Pathological and clinical findings in a series of 22 cases of medullary carcinoma of the thyroidat the korle-bu teaching hospital (1994-2013)

Der¹

2017

Pathol Discov

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There is paucity of published data on medullary thyroid cancer (MTC) as a single entity in Ghana and Africa as a whole despite its first description six decades ago. The aim of this study was to determine the proportions of thyroid malignancies diagnosed in the department of pathology of the Korle-Bu Teaching Hospital (KBTH) between 1994-2013 that were MTCs and the clinicopathological characteristics by a retrospective histopathological study. Material and methods:This was a retrospective study in KBTH from 1994 to 2013. Results: During the period under review, MTC was found to be the third common thyroid malignancy, accounting for 10.0% of all the cases. The mean age of patient was 38.4 years (SD±16.0) with half (50.0%) being younger than 40 years of age. The male to female ratio was 1:1. The modal age of the males was 40 -49 years (27.3%), but that for the females was 20-29 years (36.4%). Anterior neck swelling was the commonest presentation of MTCs (95.5%), particularly diffuse gland involvement (45.5%). Males with MTC presented relatively early within two years (50.0%), compared to females who commonly presented after 5 years (37.5%) with the disease. AMTCs were commonly diagnosed in lobectomy specimens (44.4%). Two of the females had neck dissection (18.2%). Extra-glandular spread at diagnosis was found in lymph nodes (22.7%), lymphovascular space (13.6%) and neck muscles (13.6%). Conclusion: Medullary thyroid cancer was found to be the third common thyroid malignancy at KBTH with no significant sex differences in the clinical presentation. Patients commonly presented with large anterior neck swelling of variable duration. Approximately 59.1% of the patients had organ confirmed disease at diagnosis.

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Section: Discussionsupporting

confidence: 67%

Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Pathological and clinical findings in a series of 22 cases of medullary carcinoma of the thyroidat the korle-bu teaching hospital (1994-2013)

Der¹

2017

Pathol Discov

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“…It was observed that this patient with the medullary carcinoma was a male, as observed by Desai SS et al in 2005 who showed a male predominance in medullary carcinoma of the thyroid. 17 Presence of amyloid was confirmed by special stains using Congo-red and Crystal-violet (Fig 5,6,7) in the histopathological examination. One case of follicular neoplasm on FNAC was confirmed to be a follicular carcinoma with the presence of capsular and vascular invasion on histology (Fig 8).…”

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confidence: 99%

A comparative study of free-hand fine needle aspiration cytology and ultrasound guided fi ne needle aspiration cytology in the diagnosis of thyroid swellings at BP Koirala Institute of Health Sciences- a tertiary care centre in Nepal

et al. 2015

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Background: Thyroid lesions are commonly encountered in clinical practice and it is mandatory to know and record the nature of pathology prior to definitive therapy. Fine needle aspiration cytology (FNAC) is a time tested, cheap, reliable and safe method to establish a cytological diagnosis of the nature of the disease. Ultrasound guided FNAC has the potential to reduce inadequacy rates and is regarded as the optimal cytological method for diagnosis. Objective: To compare the results of free-hand and ultrasound-guided FNAC of thyroid swellings and to find out the diagnostic reliability of free-hand FNAC and ultrasound-guided FNAC using histological diagnosis as the gold standard. Methods: Fifty-five patients with thyroid swelling who were subjected to free-hand and ultrasound-guided FNACs and who subsequently underwent surgery over one year were studied. Results: Ultrasound guided FNAC results revealed 72.75 % benign lesions and 25.45 % of malignant lesions, and free hand FNAC revealed 52.73 % benign and 16.36% malignant cases. A 14.55 % inadequacy rate was seen in the free hand group. Histological gold standard diagnosis comprised of 60 % benign and 40 % malignant cases. Sensitivity and specificity of free-hand and ultrasound guided FNAC in diagnosing malignancy of the thyroid were 56.25% and 100%; and 63.64% and 96.97% respectively. Conclusion: Free hand FNAC of thyroid swellings is more convenient and cost effective as compared to ultrasound guided FNAC. However, the diagnostic yield in ultrasound guided FNAC is significantly more in terms of accuracy especially in cystic and tiny lesions.

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Cytologic diagnosis of recurrent medullary thyroid carcinoma with oncocytic change twenty‐one years post‐thyroidectomy: Case report and review of the literature

Tranchida¹,

Estigarribia²,

Sethi³

et al. 2010

Diagnostic Cytopathology

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A 66-year-old woman presented 21 years prior with diarrhea and elevated serum calcitonin levels. The left lobe of the thyroid was aspirated but specimen was unsatisfactory. Nevertheless, based on the radiological and clinical impressions, the patient underwent total thyroidectomy and the histologic examination established the diagnosis of medullary thyroid carcinoma (MTC). Approximately 5 years later, the patient had a recurrence of the disease and underwent a neck lymph node dissection, which showed metastatic MTC in a lymph node. Sixteen years later, the patient presented with left neck mass detected by ultrasound in the area of thyroid bed. Fine needle aspiration (FNA) of this area was performed and the FNA diagnosis was consistent with oncocytic variant of MTC. This case illustrates a first report of this uncommon variant of MTC diagnosed by FNA cytology of the thyroid bed.

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A study of histopathological features of medullary carcinoma of the thyroid: Cases from a single institute in India

Abstract: BACKGROUND:The microscopic features of medullary carcinoma have been described in world literature, together

Cited by 23 publications

References 11 publications

Pathological and clinical findings in a series of 22 cases of medullary carcinoma of the thyroidat the korle-bu teaching hospital (1994-2013)

Pathological and clinical findings in a series of 22 cases of medullary carcinoma of the thyroidat the korle-bu teaching hospital (1994-2013)

A comparative study of free-hand fine needle aspiration cytology and ultrasound guided fi ne needle aspiration cytology in the diagnosis of thyroid swellings at BP Koirala Institute of Health Sciences- a tertiary care centre in Nepal

Cytologic diagnosis of recurrent medullary thyroid carcinoma with oncocytic change twenty‐one years post‐thyroidectomy: Case report and review of the literature

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