A Study of Hypoalbuminemia in Critically ill Children in Pediatric Intensive Care Unit

Girish, N; Srinivas, H A; Soumya, A

doi:10.5958/2321-1032.2016.00010.3

Cited by 2 publications

(1 citation statement)

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“…We found hyperlactatemia and low serum albumin levels to be significant predictors of mortality. Because albumin is a marker for nutritional status, inflammatory response, and the severity of the disease, low serum albumin values are believed to be a significant factor for increased morbidity and mortality in children followed up in the PICU [22]. We detected hypoalbuminemia in 27.2% of the patients, and in 61.9% of those it led to a mortal condition; thus, hypoalbuminemia increased mortality by 0.2 fold.…”

Section: Discussionmentioning

confidence: 69%

Platelet-lymphocyte ratio in predicting mortality of patients in pediatric intensive care unit

Mısırlıoğlu¹

2018

Ann Clin Anal Med

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Aim: Patients in the PICU have high rates of mortality. In this study we researched whether platelet-lymphocyte ratio (PLR), in addition to other scoring methods, is an early predictor of mortality risk in PICU patients. Material and Method: The patient files of children hospitalized in the PICU between 2014 and 2015 were examined. Results: A total of 670 patients were included (46.9% girls and 53.1% boys). 25 (3.7%) of these children died. In patients who died, the GCS was below 9, and PRISM, PELOD, and PIM2 scores were above 12, 7, and 90, respectively (p<0.001 for each factor). Significant cut-off values were 2 (p<0.001) for lactate (100% sensitivity, 64.3% specificity) and 3.9 (p<0.001) for PLR (80% sensitivity, 68.9% specificity). Diagnoses such as hematological-oncological diseases, sepsis, or multi-organ failure in children admitted to the PICU were factors affecting mortality (p=0.001, p=0.008, and p<0.001, respectively). Other factors affecting mortality were found to be high PIM2 scores (p=0.041), hyperlactatemia (p<0.001), and high PLR (p<0.001). Discussion: In addition to known scoring methods, PLR is a beneficial predictive factor of mortality rate in PICU patients.

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Section: Discussionmentioning

confidence: 69%

Platelet-lymphocyte ratio in predicting mortality of patients in pediatric intensive care unit

Mısırlıoğlu¹

2018

Ann Clin Anal Med

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Silver nanoparticles and platelet-rich fibrin accelerate tendon healing in donkey

Abdelhakiem

Hussein

Seleim

et al. 2023

Sci Rep

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This study investigated the effect of the silver nanoparticles (AgNPs) and platelet-rich fibrin (PRF) in the healing of the severed superficial digital flexor tendon in donkeys (SDFT). Twenty-seven adult donkeys were used in the study. The animals were divided into three equal groups. The first group (control group) in which the severed SDFT was sutured without the addition of any adjuvant. In the second group, there was a suture of severed SDFT with the addition of 1 ml of 1 mM silver nanoparticles (AgNPs group). The third group was subjected to the cutting of SDFT and then the addition of PRF after its suture. Each group of animals was divided into three equal subgroups that were examined after 1, 2, and 3 months. Each group of animals was clinically evaluated by assessing lameness. Gross and microscopic examinations of the healed tendons were performed after 1, 2, and 3 months of surgery. In comparison to the control group, the lameness degree decreased in the PRF and AgNPs groups, particularly in the third month after surgery. Furthermore, the lameness decreased significantly after the 3rd month relative to the 1st-month lameness in the AgNPs group. Interestingly, it was found that the PRF and AgNPs enhanced cell alignment and collagen deposition at the site of tendon injury, particularly among third-month subgroups. Therefore, it could be concluded that the PRF and AgNPs are effective materials for enhancing SDFT healing in donkeys.

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A Study of Hypoalbuminemia in Critically ill Children in Pediatric Intensive Care Unit

Cited by 2 publications

References 0 publications

Platelet-lymphocyte ratio in predicting mortality of patients in pediatric intensive care unit

Platelet-lymphocyte ratio in predicting mortality of patients in pediatric intensive care unit

Silver nanoparticles and platelet-rich fibrin accelerate tendon healing in donkey

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