A study of immuno-genetic tracers in a pair of discordant twins with blood chimera

Gilgenkrantz, Simone; Janot, C.; Perrier, P.; Streiff, F; Seger, J; Salmon, Ch.

doi:10.1016/s0338-4535(81)80023-2

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Twin Chimeras2

Proportions Of the Mixtures1

Changes In Proportions Of Two Populations Of Cells1

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1983

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Cited by 3 publications

(4 citation statements)

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“…The twin chimeras described by Gilgenkrantz et al [27,28] and Massimo et al [45] are included (Appendix Id), although they did not show red cell mixtures.…”

Section: Twin Chimerasmentioning

confidence: 99%

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Blood Group Chimeras

Tippett¹

1983

Vox Sanguinis

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“…The twin chimeras described by Gilgenkrantz et al [27,28] and Massimo et al [45] are included (Appendix Id), although they did not show red cell mixtures.…”

Section: Twin Chimerasmentioning

confidence: 99%

“…The twin pair T27 (Appendix Id) re ported by Gilgenkrantz et al [27,28] suggest that an abnormal cell line may be at a dis advantage. At birth Corinne had the typical appearance of Down's syndrome, so the chromosomes of the lymphocytes of both twins were analyzed.…”

Section: Proportions Of the Mixturesmentioning

confidence: 99%

Blood Group Chimeras

Tippett¹

1983

Vox Sanguinis

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“…The twins are divided into pairs ofchimeric twins (Appendix la), chimeras with twins but whose twin was dead or inadequately tested (Appendix lb), or whose twin showed no signs ofmixtures (Appendix lc). The twin chimeras described by Gilgenkrantz et al [27,28] and Massirno et al [45] are included (Appendix Id), although they did not show red cell mixtures.…”

Section: Twin Chimerasmentioning

confidence: 99%

“…The twin pair T27 (Appendixld) reported by Gilgenkrantz et al [27,28] suggest that an abnormal cell line may be at a disadvantage. At birth Corinne had the typical appearance of Down's syndrome, so the chromosomes of the lymphocytes of both twins were analyzed.…”

Section: Changes In Proportions Of Two Populations Of Cellsmentioning

confidence: 99%

Blood Group Chimeras: A Review

Tippett

1983

Vox Sanguinis

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Monozygotic twins discordant for trisomy 21 or chimeric dizygotic twins?

et al. 1983

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We read with interest the article by Rogers et a1 (Am J Med Genet 11: 143-146, 1982) on monozygotic (MZ) twins discordant for trisomy 21. The twins are presumed to be MZ on the basis of placentation, identical blood groups, HLA haplotypes, and serum proteins.We have studied a similar set of twins [Gilgenkrantz et al, 1981a,b]. They were diarnniotic monochorial and their blood groups were identical. One was a normal child and the other had Down Syndrome (DS). Mixoploidy was found in peripheral blood in both of them. We could have concluded monozygoty twins if they had been of the same sex, but the normal child was a boy and the DS child was a girl. In skin fibroblast culture the chromosome constitution conformed to the phenotype 46,XY in the normal boy and 47,XX, +21 in the DS girl.So, we concluded on dizygoty with blood chimerism due to placental vascular anastomoses. We could prove this because the a-1 antitrypsin phenotypes (a serum enzyme of hepatic origin) were different in our twins.Although HLA typing was performed on cultured skin fibroblasts in the case of Rogers et al, we still wonder if their twins could be DZ twins with predominant blood chimera rather MZ twins discordant for trisomy 21.

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A study of immuno-genetic tracers in a pair of discordant twins with blood chimera

Cited by 3 publications

References 15 publications

Blood Group Chimeras

Blood Group Chimeras

Blood Group Chimeras: A Review

Monozygotic twins discordant for trisomy 21 or chimeric dizygotic twins?

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