A Study of Immunotherapeutic Efficacy of Trichinella Spiralis Excretory-Secretory Proteins in Murine Trichinellosis

AL-ATTAR, TAHANY; El-Kersh, Wafaa M; Sadek, Gehan S; Harba, Nancy M.; Osheiba, Salwa Fouad; Brakat, Reham Mustafa

doi:10.21608/jesp.2020.113049

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…Trichinella is the smallest nematode parasitizing humans with a clinically significant impact (Pozio, 2015). The disease has a substantial public health impact on humans as well as high economic cost in terms of pig husbandry and food safety (Nöckler et al, 2005) as it results in high rates of morbidity and mortality (Al-Attar et al, 2020;Bai et al, 2022).…”

Section: Trichinellamentioning

confidence: 99%

A mini Review of New Potential Therapeutic Strategies Against Trichinellosis

Ebrahim,

Elkhawass,

Nabil

et al. 2024

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Trichinella spiralis is a parasitic nematode transmitted through the consumption of contaminated meat. The study aims to provide comprehensive information on various aspects of trichinellosis, including its manifestations, conventional treatment methods, and emerging antitrichinellosis strategies using nanoparticles is a promising approach to overcoming the challenges posed by conventional trichinellosis treatments. The infection begins when a host ingests meat containing infective larvae of T. spiralis. The adult worms release newborn larvae (NBL) that enter the bloodstream. These NBL invade striated skeletal muscle cells and establish nurse cell-parasite complexes within the muscle tissue. Trichinella causes a public health impact and economic costs related to pig husbandry and food safety. As the prevalence of trichinellosis remains a concern, continued research, surveillance, and public awareness efforts are essential to mitigate the impact of this parasitic infection on human health and the food industry. Pursuing new and effective treatments for trichinellosis remains imperative, and ongoing research efforts are exploring innovative strategies to address the limitations of existing drugs and enhance their therapeutic outcomes. Several studies highlight the potential of specific antigens for developing vaccines that could offer protective immunity against T. spiralis infection, providing valuable insights for future research in parasitology and vaccine development. In conclusion, the integration of nanotechnology and nanoparticles holds promise for revolutionizing drug delivery systems, improving therapeutic outcomes, and offering novel approaches to treat various diseases, including parasitic infections like trichinellosis. Ongoing research in this field is likely to unveil more innovative applications and solutions in the future.

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Section: Trichinellamentioning

confidence: 99%

A mini Review of New Potential Therapeutic Strategies Against Trichinellosis

Ebrahim,

Elkhawass,

Nabil

et al. 2024

Egyptian Academic Journal of Biological Sciences, B. Zoology

View full text Add to dashboard Cite

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“…Trichinella spiralis is a serious zoonotic nematode that infects a wide range of mammals such as pigs, mice, birds, horses and humans. Trichinosis causes widespread morbidity and mortality (Al-Attar et al, 2020). Currently, T. spiralis infects more than 11 million people in Africa, Central and South America and Asia (Muñoz-Carrillo et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Egyptian propolis and selenium nanoparticles against murine trichinosis: a novel therapeutic insight

et al. 2022

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Trichinosis is a serious zoonotic disease that causes human morbidity and mortality. New effective natural remedies with minimal side effects that are well tolerated are needed to treat both enteral and parenteral trichinosis. This study evaluated the efficacy of selenium (Se), Se nanoparticles (SeNPs) and Egyptian propolis compared with albendazole as antiparasitic, anti-inflammatory and anti-angiogenic agents for treating murine trichinosis. We used parasitological, histopathological and immunohistochemical assays, as well as scanning electron microscopy, to examine adult worms. Overall, 80 Swiss albino male mice were divided into eight groups, with ten mice in each group, as follows: negative control, positive control, albendazole, propolis, Se, combination of propolis and Se, SeNPs and combination of SeNPs and propolis. Mice were slaughtered seven and 35 days after infection to examine the intestinal and muscular phases, respectively. This study demonstrated the efficacy of the combination of SeNPs and propolis. As revealed by electron microscopy, this combination caused damage to the adult worm cuticle. Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles. In conclusion, the combination of SeNPs and propolis had antiparasitic, anti-inflammatory and anti-angiogenic effects on trichinosis. Consequently, this combination could be used as a natural alternative therapy to albendazole for treating trichinosis.

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