A Study of Lipid Peroxidation and Antioxidants in Patients with Type 2 Diabetes Mellitus with and without Neuropathy

Pujar, Sunita; Hiremath, Kavitha; Pujar, L.L.; Mannangi, Neela; Bhuthal, Mahanthesh

doi:10.5958/2321-1032.2015.00017.0

Int. Jour. of Contemp. Med.

2015

DOI: 10.5958/2321-1032.2015.00017.0

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A Study of Lipid Peroxidation and Antioxidants in Patients with Type 2 Diabetes Mellitus with and without Neuropathy

Sunita Pujar¹,

Kavitha Hiremath²,

L.L. Pujar³

et al.

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Comparison of serum copper and zinc in diabetics and non-diabetics subjects

Datta¹,

Belle²,

G³

2020

IJCBR

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Diabetes mellitus, the most common chronic metabolic disorder affecting about 300 million people all over the world. It occurs due to impaired insulin secretion, impaired insulin action or both whereas Prediabetes is the initial stage before diabetes mellitus and characterized by impaired fasting glucose or impaired glucose tolerance. Type 2 diabetes mellitus is associated with increased metabolic processes and oxidative stress. The trace elements are important co-factor in these events. Thus, this study was conducted to compare serum copper, zinc in prediabetes, diabetics with normal controls.Institutional ethics committee permission was obtained prior to the study. Study included 71 prediabetes, 71 diabetics subjects and 71 controls between 40-60 years. Serum fasting blood sugar, glycated hemoglobin, copper, zinc was estimated. Statistical analysis was done using student t-test and Pearson’s correlation. p value <0.05 was said to be significant.Serum copper was significantly increased in diabetic (77.87±40.78) and serum zinc (128.05±20.87) was significantly decreased in diabetics compared to apparently healthy controls. (Copper =60.72±19.70, zinc =140.74±33.99), where as in prediabetics both copper and zinc level were increased compared to healthy subjects. : Serum copper and zinc have a role in diabetes thus supplementation of micronutrients may be essential to maintain the diabetic status.

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Comparison of serum copper and zinc in diabetics and non-diabetics subjects

Datta¹,

Belle²,

G³

2020

IJCBR

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Correlation of serum magnesium with HbA1c in patients with diabetes mellitus

Ahmed

Sultana

Akter

2022

IMC Journal of Medical Science

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Background and objectives: Diabetes mellitus (DM) is a leading cause of death and disability world wide. Magnesium acts as a cofactor in glucose metabolism and its decreased level causes insulin resistance and many complications in diabetic patients. The present study evaluated the correlation of serum magnesium with HbA1c in DM patients. Materials and methods: This cross sectional study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2016 to June 2017. A total number of 100 individuals with and without diabetes mellitus were included in the study. HbA1c was measured by high performance liquid chromatography and estimation of serum magnesium was done by automatic biochemistry analyzer. Results: Out of 100 enrolled participants, 50 were diagnosed patients of DM (Group-A) and 50 were age and sex matched apparently healthy individuals (Group-B). The mean age of Group-A and B individuals was 50.5 ± 6.0 and 50.4 ± 5.1 years respectively. Group-A had significantly (p < 0.001) lower serum magnesium concentration compared to Group-B (1.5 ± 0.6 mg/dl vs 2.3 ± 0.5 mg/dl). Serum magnesium levels showed significant negative correlations with HbA1c (r = -0.511, p < 0.001). Conclusion: DM patients showed significant negative correlation of serum magnesium with HbA1c level. Routine screening for serum magnesium status would be helpful for the better management of diabetic cases. IMC J Med Sci. 2023. 17(1): 005. DOI: https://doi.org/10.55010/imcjms.17.005 *Correspondence: Farzana Ahmed, Department of Biochemistry, Ibrahim Medical College, 1/A Ibrahim Sarani, Shegunbagicha, Dhaka, Bangladesh. Email: tanvy1108@gmail.com

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A Study of Lipid Peroxidation and Antioxidants in Patients with Type 2 Diabetes Mellitus with and without Neuropathy

Cited by 2 publications

References 0 publications

Comparison of serum copper and zinc in diabetics and non-diabetics subjects

Comparison of serum copper and zinc in diabetics and non-diabetics subjects

Correlation of serum magnesium with HbA1c in patients with diabetes mellitus

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