A study of Love wave acoustic biosensors monitoring the adhesion process of tendon stem cells (TSCs)

Wu, Huiyan; Zu, Hongfei; Wang, James H.‐C.; Wang, Qing-Ming

doi:10.1007/s00249-019-01349-4

Cited by 12 publications

(12 citation statements)

References 29 publications

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“…Ideally, the cell trapping is done without intruding the substrate so that first principles can be used to get an ideal estimate of cell mechanical properties. 71 A possible solution as well as future direction is to integrate novel coupling approaches (e.g. electric, magnetic, optical, mechanical and etc.)…”

Section: Discussionmentioning

confidence: 99%

Emerging on-chip surface acoustic wave technology for small biomaterials manipulation and characterization

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Emerging on-chip surface acoustic wave technology for small biomaterials manipulation and characterization

et al. 2021

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“…In contrast, in actuation—for example, cell separation—the acoustic waves are used to isolate different cells at a certain frequency due to the difference in mass and density of the cells. Wang et al (2018) [ 171 ] used this approach for cell separation using an active SAW device, Bisoffi et al (2008) [ 172 ] used it for virus detection, Kim et al (2015) [ 173 ] used it for the evaluation of antibodies bonded to biofilm, Zhang et al (2009) [ 174 ] used the technique for detecting analytes reacting with nano rods, Wu et al (2019) [ 175 ] proposed to monitor the adhesion process of tendon stem cells, and Zhang et al (2017) [ 176 ] proposed a similar process for the detection of target DNA. Together with the quality of both sensing and actuation, the SAW platform acts as a powerful device in the field of biosensing.…”

Section: Saw Applicationsmentioning

confidence: 99%

“… Using a similar philosophy, different applications of Love-wave based SAW sensing where input frequencies and output frequencies are compared to detect the change in the bio-functionalized layer [ 171 , 172 , 173 , 174 , 175 , 176 ]. …”

Section: Figurementioning

confidence: 99%

Surface Acoustic Wave (SAW) Sensors: Physics, Materials, and Applications

Mandal

Banerjee

2022

Sensors

206

100

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Surface acoustic waves (SAWs) are the guided waves that propagate along the top surface of a material with wave vectors orthogonal to the normal direction to the surface. Based on these waves, SAW sensors are conceptualized by employing piezoelectric crystals where the guided elastodynamic waves are generated through an electromechanical coupling. Electromechanical coupling in both active and passive modes is achieved by integrating interdigitated electrode transducers (IDT) with the piezoelectric crystals. Innovative meta-designs of the periodic IDTs define the functionality and application of SAW sensors. This review article presents the physics of guided surface acoustic waves and the piezoelectric materials used for designing SAW sensors. Then, how the piezoelectric materials and cuts could alter the functionality of the sensors is explained. The article summarizes a few key configurations of the electrodes and respective guidelines for generating different guided wave patterns such that new applications can be foreseen. Finally, the article explores the applications of SAW sensors and their progress in the fields of biomedical, microfluidics, chemical, and mechano-biological applications along with their crucial roles and potential plans for improvements in the long-term future in the field of science and technology.

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“…The real-time monitoring of the phase of the biosensor showed a shift in response to the endotoxin addition, due to the added mass, with an increase in phase shift with an increased concentration of target endotoxin, as shown in Figure 31b. (ii) Cell Adhesion and Detection SAW sensors are employed for the study of the quantification of cell growth in culture media, cell-cell interactions, tissue healing, and cell adhesion onto a substrate [295][296][297]. These play an important role in monitoring cellular activity and are useful in cell culture and tissue engineering.…”

Section: (I) Protein and Biomolecular Detectionmentioning

confidence: 99%

“…study of cell-substrate adhesion plays an important role in cellular functions, such as cell migration, tissue engineering, and cell differentiation [299]. Monitoring cell-substrate adhesion can be performed using the SAW device by exploiting the sensitivity of surface waves to the viscoelastic property of adhered cells [297]. A Love wave device using 36 • YX-LiTaO 3 with Cr/Au IDT operating at a frequency of 131 MHz with parylene-C as the waveguide layer, was reported to be used for the real-time monitoring of the adhesion of tendon stem cells (TSC) to the substrate surface [300].…”

Section: (I) Protein and Biomolecular Detectionmentioning

confidence: 99%

Acoustic Biosensors and Microfluidic Devices in the Decennium: Principles and Applications

Nair

Teo

2021

Micromachines

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Lab-on-a-chip (LOC) technology has gained primary attention in the past decade, where label-free biosensors and microfluidic actuation platforms are integrated to realize such LOC devices. Among the multitude of technologies that enables the successful integration of these two features, the piezoelectric acoustic wave method is best suited for handling biological samples due to biocompatibility, label-free and non-invasive properties. In this review paper, we present a study on the use of acoustic waves generated by piezoelectric materials in the area of label-free biosensors and microfluidic actuation towards the realization of LOC and POC devices. The categorization of acoustic wave technology into the bulk acoustic wave and surface acoustic wave has been considered with the inclusion of biological sample sensing and manipulation applications. This paper presents an approach with a comprehensive study on the fundamental operating principles of acoustic waves in biosensing and microfluidic actuation, acoustic wave modes suitable for sensing and actuation, piezoelectric materials used for acoustic wave generation, fabrication methods, and challenges in the use of acoustic wave modes in biosensing. Recent developments in the past decade, in various sensing potentialities of acoustic waves in a myriad of applications, including sensing of proteins, disease biomarkers, DNA, pathogenic microorganisms, acoustofluidic manipulation, and the sorting of biological samples such as cells, have been given primary focus. An insight into the future perspectives of real-time, label-free, and portable LOC devices utilizing acoustic waves is also presented. The developments in the field of thin-film piezoelectric materials, with the possibility of integrating sensing and actuation on a single platform utilizing the reversible property of smart piezoelectric materials, provide a step forward in the realization of monolithic integrated LOC and POC devices. Finally, the present paper highlights the key benefits and challenges in terms of commercialization, in the field of acoustic wave-based biosensors and actuation platforms.

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A study of Love wave acoustic biosensors monitoring the adhesion process of tendon stem cells (TSCs)

Cited by 12 publications

References 29 publications

Emerging on-chip surface acoustic wave technology for small biomaterials manipulation and characterization

Emerging on-chip surface acoustic wave technology for small biomaterials manipulation and characterization

Surface Acoustic Wave (SAW) Sensors: Physics, Materials, and Applications

Acoustic Biosensors and Microfluidic Devices in the Decennium: Principles and Applications

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