2015
DOI: 10.1007/s00705-015-2401-7
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A study of lymphoid organs and serum proinflammatory cytokines in pigs infected with African swine fever virus genotype II

Abstract: African swine fever virus (ASFV), the causative agent of one of the most important viral diseases of domestic pigs for which no vaccine is available, causes immune system disorders in infected animals. In this study, the serum levels of proinflammatory cytokines, as well as the histological and cellular constitution of lymphoid organs of pigs infected with ASFV genotype II were investigated. The results showed a high degree of lymphocyte depletion in the lymphoid organs, particularly in the spleen and lymph no… Show more

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Cited by 33 publications
(28 citation statements)
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“…Thus, compared with the 10 genes significantly up and down-regulated by day 1 pi with E75CV1, E75 only up-regulated 4, namely: IL - 12p40 , TGF - βR1 , TNF - α and IL - 21 , with key activation markers such as s CD163 , IFN - γ and IL - 4 showing tendency towards being down-regulated (Figure 6 A). This tendency totally reverted through the infection course and by day 7 pi the activation of a massive number of immune mediators was observed as demonstrated in here with the significant up-regulation of: IL - 5 , DEFB2 , TLR - 3 , IL - 6 , IL - 8 , IL - 1β , IL - 21 , IL - 23 and IL - 10 ; coinciding with the cytokine storm described during the terminal phase of acute ASF [ 36 ] (Figure 6 B). The transcription profile observed in the gastrohepatic lymph nodes of E75CV1-infected pigs showed an inverted cytokine response when compared to that of E75.…”
Section: Resultssupporting
confidence: 54%
“…Thus, compared with the 10 genes significantly up and down-regulated by day 1 pi with E75CV1, E75 only up-regulated 4, namely: IL - 12p40 , TGF - βR1 , TNF - α and IL - 21 , with key activation markers such as s CD163 , IFN - γ and IL - 4 showing tendency towards being down-regulated (Figure 6 A). This tendency totally reverted through the infection course and by day 7 pi the activation of a massive number of immune mediators was observed as demonstrated in here with the significant up-regulation of: IL - 5 , DEFB2 , TLR - 3 , IL - 6 , IL - 8 , IL - 1β , IL - 21 , IL - 23 and IL - 10 ; coinciding with the cytokine storm described during the terminal phase of acute ASF [ 36 ] (Figure 6 B). The transcription profile observed in the gastrohepatic lymph nodes of E75CV1-infected pigs showed an inverted cytokine response when compared to that of E75.…”
Section: Resultssupporting
confidence: 54%
“…Experimental infections occur with the development of clinical signs at 7–10 days post inoculation that can be considered late times of infection. At that time, histopathological evaluation shows typical alterations of the disease such as macrophage infiltrations and apoptotic cells together with a cytokine storm characteristic of the terminal phase in ASF infections according to previous studies [ 9 ].…”
Section: Introductionsupporting
confidence: 57%
“…To explain the pathology, we must identify a specific pathology type in ASF - hypercytokinemia [34]. Hypercytokinemia occurs in response to sepsis (including viral pneumonias) resulting in an abnormally increase of primary proinflammatory cytokines of blood serum, tumor necrosis factor alpha and interleukin-1 (IL-1).…”
Section: Discussionmentioning
confidence: 99%