A Study of Microalbuminuria in Rheumatoid Arthritis : A Correlation With Disease Activity

Bora, Mitul; Loitongbam, Roslin; Kakati, Sanjeeb; Barman, Bhupen; Deka, Utpal Jyoti

doi:10.14260/jemds/2014/3928

Cited by 2 publications

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“…Previous studies have documented distinct genetic susceptibility loci and suggest the presence of a considerable burden of clinical sequelae such as renal dysfunction and osteoporosis in RA patients from northeast India. [ 12 , 13 , 14 ] However, there is a paucity of studies investigating CVD risk or the magnitude of MetS and its determinants in RA patients from the region. With this background, the current study aimed to study the magnitude of MetS and its determinants in RA patients from northeast India.…”

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confidence: 99%

Metabolic syndrome and atherogenic indices in rheumatoid arthritis and their relationship with disease activity: A hospital-based study from northeast India

Bhattacharya

Barman

Jamil

et al. 2020

Journal of Translational Internal Medicine

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Background and ObjectiveMetabolic syndrome (MetS), a constellation of metabolic abnormalities including hypertension, obesity, glucose intolerance, and dyslipidemia, is highly prevalent in patients with rheumatoid arthritis (RA). Our aim was to assess the magnitude of MetS and its determinants in RA patients and to evaluate different atherogenic indices that are reflective of the risk for future cardiovascular disease.Patients and MethodsThe study was conducted on 104 RA patients and 103 age- and sex-matched healthy controls. The frequency of MetS was assessed using the guidelines recommended for Asian Indians.ResultsA total of 104 RA patients participated with majority being females (85.6%), with a mean age of 43.82 ± 13.32 years. The frequency of MetS in patients with RA (36.5%) was significantly higher than in controls (15.5%). The atherogenic indices were found to be significantly higher in RA patients than controls (P < 0.01). On logistic regression, disease activity score (DAS28) scale for 28 joints and disease duration remained significant independent predictors of the presence of MetS in RA patients (P < 0.01 and 0.05, respectively).ConclusionsRA is a kind of chronic disease of long course, and MetS and atherogenic indices are often concomitant in these patients. The study showed that the frequency of MetS was higher in patients with RA than in controls, and that DAS28 and disease duration remained significant independent predictors of the presence of MetS in RA patients.

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Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and atherogenic indices in rheumatoid arthritis and their relationship with disease activity: A hospital-based study from northeast India

Bhattacharya

Barman

Jamil

et al. 2020

Journal of Translational Internal Medicine

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The role of microalbuminuria as a predictor of subclinical cardiovascular events in rheumatoid arthritis patients and its relation to disease activity

et al. 2017

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Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects many body tissues and leads to major morbidity and mortality. Renal disease in RA is clinically important because it restricts the management of primary disease and increases mortality. The objectives of this study are to (1) investigate the difference between RA patients with and without microalbuminuria (MAU) and (2) find out the relation between MAU and disease activity as well as subclinical cardiovascular effects. Ninety RA patients were divided into two groups according to the presence of MAU, in addition to 30 healthy volunteers. ESR, hs-CRP, RF, lipid profile, urinary microalbumin, GFR, renal function tests, carotid intima media thickness (cIMT), flow-mediated dilatation of the brachial artery (FMD), ECG, and echocardiographic examination were performed for patients and controls. MAU positive RA patients revealed significantly higher lipid profile, ESR, hs-CRP, DAS 28, cIMT, and lower FMD as well as ECG and echocardiographic abnormalities compared to MAU negative RA patients. Moreover, there was significant positive correlation between MAU and DAS28, hs-CRP, LDL, cIMT as well as negative correlation with FMD%. In our study, all RA patients with MAU had a normal serum creatinine concentration and gave a negative result with Albustix. MAU is significantly correlated with ESR, hs-CRP, lipid profile, cIMT, and FMD% in RA patients; therefore, it can be used as an index to measure disease activity as well as subclinical cardiovascular affection in RA patients.

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A Study of Microalbuminuria in Rheumatoid Arthritis : A Correlation With Disease Activity

Cited by 2 publications

References 8 publications

Metabolic syndrome and atherogenic indices in rheumatoid arthritis and their relationship with disease activity: A hospital-based study from northeast India

Metabolic syndrome and atherogenic indices in rheumatoid arthritis and their relationship with disease activity: A hospital-based study from northeast India

The role of microalbuminuria as a predictor of subclinical cardiovascular events in rheumatoid arthritis patients and its relation to disease activity

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