A Study Of Moisture Vapor Transmission Through Closures**College of Pharmacy, State University of Iowa, Iowa City

Effect of Water Vapor Pressure on Moisture Sorption and the Stability of Aspirin and Ascorbic Acid in Tablet Matrices

“…Kovacs (4) reported that the rate of absorption of water vapor by cellulose films followed Fick's law of diffusion and that the absorption from the liquid state was greater than that from the vapor state. I n a study of moisture penetration through closures, Blaug et al (5) revealed that the cap liner was just as important as the cap itself for effective moisture proof sealing. They also reported the effect of reduced moisture contents in tablet formulations and indicated that tablets prepared with anhydrous calcium sulfate as the filler in place of lactose exhibited the best color stability (6).…”