A study of neural and extraneural findings in a large family with Friedreich's ataxia

Heck, Albert F.

doi:10.1016/0022-510x(64)90002-4

Cited by 25 publications

(9 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These involuntary movements are normal in childhood, but decrease between the ages of seven and ten years (Connolly & Stratton, 1968;Nakada et al, 1998;Nass, 1985). Persistence of mirror movements into adulthood is considered to be abnormal and may be familial (Bauman, 1932;Heck, 1964;Regli et al, 1967;Somers et al, 1976;van den Berg et al, 2000). However, neurologically intact individuals do exhibit mirror movements when performing tasks involving muscle fatigue and extremes of effort (Armatas et al, 1994(Armatas et al, , 1996a(Armatas et al, , 1996bCernacek, 1961;Liederman & Foley, 1987;Stern et al, 1976;Todor & Lazarus, 1986;Yensen, 1965).…”

Section: Introductionmentioning

confidence: 94%

The influence of attention and age on the occurrence of mirror movements

Baliz

Armatas

Farrow

et al. 2005

J. Inter. Neuropsych. Soc.

View full text Add to dashboard Cite

This study utilised a finger force task to investigate the influence of attention and age on the occurrence of motor overflow in the form of mirror movements in neurologically intact adults. Forty right-handed participants were recruited from three age groups: 20-30 years, 40-50 years, and 60-70 years. Participants were required to maintain a target force using both their index and middle fingers, representing 50% of their maximum strength capacity for that hand. Attention was directed to a hand by activating a bone conduction vibrator attached to the small finger of that hand. Based on Cabeza's (2002) model of hemispheric asymmetry reduction in older adults, it was hypothesised that mirror movements would increase with age. Furthermore, it was expected that when the attentional demands of the task were increased, motor overflow occurrence would be exacerbated for the older adult group. The results obtained provide support for the model, and qualified support for the hypothesis that increasing the attentional demands of a task results in greater motor overflow. It is proposed that the association between mirror movements and age observed in this study may result from an age-related increase in bihemispheric activation that occurs in older adults, who, unlike younger adults, benefit from bihemispheric processing for task performance. (JINS, 2005, 11, 855-862.)

show abstract

Section: Introductionmentioning

confidence: 94%

The influence of attention and age on the occurrence of mirror movements

Baliz

Armatas

Farrow

et al. 2005

J. Inter. Neuropsych. Soc.

View full text Add to dashboard Cite

show abstract

“…As far as optic disc pallor is concerned, Heck [11] found no optic nerve fiber atrophy while Geoffroy et al [10] observed it in 50% of their cases. More recently Carrol et al [4] have reported disc pallor in 11 out of 15 patients.…”

Section: Discussionmentioning

confidence: 98%

“…axon degenera tion and demyelination) have been suggested as being responsible for the abnormalities documented by visual evoked potentials (VEPs) [3,4,17,22], somatosensory evoked potentials (SEPs) [12] and auditory evoked po tentials (AEPs) [1,20] studies. While there is general agreement about the VEP changes in FA, optic atrophy has not been well defined and its reported incidence var ies in the neuro-ophthalmological and clinical literature [4,10,11], Since the impairment of visual function can be insidious and may not be subjectively perceived, sen sitive objective ophthalmological tests are needed. Redfree light retinography can detect subtle signs of retinal nerve fiber atrophy even before the appearance of disc pallor [16], Electrophysiological studies including pattern elec troretinogram (PERG) and VEP recordings provide in formation on the function of deeper retinal layers and on stimulus conduction and processing in the visual system.…”

mentioning

confidence: 99%

Visual Involvement in Friedreich’s Ataxia: PERG and VEP Study

et al. 1988

View full text Add to dashboard Cite

Neuro-ophthalmological assessment, including red-free light retinography, in conjunction with simultaneous visual evoked potential (VEP) and pattern electroretinogram (PERG) recordings were performed in 10 Friedreich’s ataxia patients: 9 patients showed marked VEP abnormalities. Moderate PERG amplitude reduction, with normal latencies, was related to mild and scattered fiber loss revealed by red-free light retinography. The initial part of the visual pathways does not seem to be the main site of electrophysiological abnormalities as demonstrated by the greater extent and relative independence of VEP versus PERG alterations. Primary axonal degeneration of the optic nerve and tracts cannot account for all features of VEP abnormalities, thus implying some dysfunction in succeeding visual structures as well.

show abstract

“…In der Literatur werden unterschiedliche Werte zur Prävalenz dysarthrischer Störungen bei FA angegeben. Im fortgeschrittenen Stadium leiden wohl alle Patienten an einer Dysarthrie (Tyrer und Sutherland 1961, Heck 1964, Brain und Walton 1969, Geoffroy et al 1976). Gelegentlich sollen sprechmotorische Defizite sogar das Initialsymptom darstellen (Heck 1963). Das Vorkommen einer u. a. durch unregelmäßige und explosive Artikulation gekennzeichneten Dysarthrie wurde auch beim Roussy-Levy-Syndrom beobachtet (Spillane 1940, Lusso 1952.…”

Section: Symptomatologie Der Sprech-und Stimmstörungen Bei Zerebeuäreunclassified

Die zerebelläre Dysarthrie - eine Literaturübersicht

Ackermann¹,

Ziegler²

1992

Fortschr Neurol Psychiatr

View full text Add to dashboard Cite

This review summarizes and discusses the literature on speech deficits in cerebellar diseases and on the topography of cerebellar dysarthria. Clinical descriptions of dysarthric features in cerebellar diseases, parametric investigations of ataxic dysarthria, and experimental studies in animals concerning the effects of lesions on vocalization and the representation of sensorimotor orofacial functions in the cerebellum are considered. Signs of cerebellar dysarthria include a slowing down of articulatory movements, increased variability of pitch and loudness, monotonous and "scanning" speech, and articulatory impreciseness. The available data indicate that the paramedian regions of the superior cerebellar hemispheres are relevant for the development of cerebellar dysarthria.

show abstract

A study of neural and extraneural findings in a large family with Friedreich's ataxia

Cited by 25 publications

References 39 publications

The influence of attention and age on the occurrence of mirror movements

The influence of attention and age on the occurrence of mirror movements

Visual Involvement in Friedreich’s Ataxia: PERG and VEP Study

Die zerebelläre Dysarthrie - eine Literaturübersicht

Contact Info

Product

Resources

About