A study of non-obese diabetes mellitus in adults in a tertiary care hospital in Kerala, India

Chandni, R; Paul, Binoy J; Udayabhaskaran, V; Ramamoorthy, Kollengode Parameswaran

doi:10.1007/s13410-013-0113-7

Cited by 11 publications

(12 citation statements)

References 9 publications

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“…A very low level of C-peptide confirms Type I diabetes and insulin dependence and is associated with high glucose variability, hypoglycaemia and increased complications. The test may be less helpful close to diagnosis, particularly where a patient is overweight and insulin resistant, as levels close to diagnosis in Type I diabetes may be high and overlap with those seen in type II diabetes [58]. In the present study, serum C-peptide and insulin was profoundly decreased and elevated level of C-reactive protein was observed in diabetic rats.…”

Section: Discussioncontrasting

confidence: 46%

Hypoglycemic and hypolipidemic effects of Aerva lanata (Linn.) on alloxan induced diabetic rats

2016

J App Biol Biotech

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Diabetes mellitus is a chronic disorder of carbohydrate, protein, fat and mineral metabolism. The antidiabetic potential of aqueous extracts flower and root of Aerva lanata was evaluated in alloxan induced diabetic rats. Alloxan (150 mg/kg bw) induced diabetic rats showed a hyperglycemic state that led to various biochemical and metabolic alterations. The aqueous extract of flower and root of A. lanata (200 mg/kg bw) was administrated orally to diabetic rats for 45 days. In this study, the levels of fasting blood glucose, glycated hemoglobin (HbA1C), C-reactive protein (CRP), total cholesterol, triglycerides (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), urea, and creatinine were significantly increased in diabetic rats. Body weight, hemoglobin, insulin, C-peptide and protein levels in blood were significantly decreased in alloxan induced diabetic rats. After the administration of extracts of flower and root of A. lanata to diabetic rats showed significantly restore the levels as normal rats. The antidiabetic effect of A. lanata was compared with strandard drug glibenclamide (1 mg/kg bw) treated rats. From this study, we concluded that the aqueous extract of A. lanata root have more antidiabetic effect when compared with flower extract. Therefore, the flower and root of A. lanata may be used as the alternative medicine for the treatment of diabetes mellitus.

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Section: Discussioncontrasting

confidence: 46%

Hypoglycemic and hypolipidemic effects of Aerva lanata (Linn.) on alloxan induced diabetic rats

2016

J App Biol Biotech

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“…Prevalence of GADA positivity and LADA in the current study was much lower than demonstrated in Southern India [27,38]. This is contrary to the findings observed in China and Europe, where compared to north, the frequency of LADA was lower in the southern region [9,18,[39][40][41][42].…”

Section: Discussioncontrasting

confidence: 97%

“…Past studies involving Indian subjects have resulted in inconclusive heterogeneous information which can be attributed to the discrepancy in methodology adopted by various investigators to diagnose LADA [26,27].…”

Section: Discussionmentioning

confidence: 99%

Latent Autoimmune Diabetes in Adults (LADA): The Prevalent Form of Adult-Onset Autoimmune Diabetes in a Region of India

Kumar¹,

Leiva²

2017

JED

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Aims: We undertook a study to investigate the prevalence and general characteristics of patients with Latent autoimmune diabetes in adults (LADA).Methods: This was a cross-sectional investigation conducted in the National Capital Region of India. Total of 139 subjects were recruited in the study. All subjects were screened for Glutamic acid decarboxylase autoantibody (GADA). GADA was analysed using ELISA kits with 98% specificity and 92% sensitivity. Results:The prevalence of LADA was 6.5% (6.3% in men and 6.8% in women); 95% Confidence interval (CI): 3.29 -12.0% among adult-onset diabetic patients. Prevalence of LADA seemed to gradually decline with increasing age. LADA (n=9) and DM2 (n=130) patients were compared. LADA patients were younger (p = 0.045), had lower age at onset of diabetes (p = 0.025), waist circumference (p = 0.021). LADA patients had also longer duration of diabetes (p = 0.045). There was no significant difference in BMI between two groups. Conclusions:Our results indicate that LADA represents 6.5 % of cases among adult-onset diabetes in a region of north India. LADA is a prevalent form of adult-onset autoimmune diabetes and not rare. This study shows different phenotypic features of LADA patients compared to DM2 patients. In the developing world, sometimes routine antibody testing may be considered not to be cost-effective. Thus, clinical and phenotypic features of LADA may help clinicians recognize patients for potential antibody screening.

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“…With reference to the prevalence of LADA in India, studies have revealed controversial results Such variation in results may be attributed to the differential aspects such as age at onset, demographics of the studied subjects, and methods used to measure GAD/Protein tyrosine phosphatase‐like protein (IA‐2) antibodies. Considerably, high prevalence of LADA was reported in few studies . These studies included specific subgroup of subjects who were young, nonobese, and had early onset of diabetes with higher probability of LADA .…”

Section: Comparision Of Lada Between Asian and Western Populationmentioning

confidence: 99%

“…Considerably, high prevalence of LADA was reported in few studies. 36,37,46 These studies included specific subgroup of subjects who were young, nonobese, and had early onset of diabetes with higher probability of LADA. 37,38 Such results may not represent the true prevalence of LADA in Indian population.…”

Section: Epidemiologymentioning

confidence: 99%

Latent autoimmune diabetes in adults (LADA) in Asian and European populations

Kumar

Leiva

2017

Diabetes Metabolism Res

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Diabetes mellitus is a chronic disorder caused by relative or absolute insulin deficiency and characterized by chronic hyperglycaemia. It is expected that by year 2025, 80% of all type 2 diabetic patients will be living in developing or low- and middle-income countries. Among Asians, there has been an overall increase in abdominal obesity; however, the risk of diabetes in these populations starts at much lower body mass index as compared to Caucasians. A significant proportion of diabetic patients with adult-onset, initially nonrequiring insulin treatment, have diabetes-associated autoantibodies in their sera. A new subclass of diabetes with the designation of latent autoimmune diabetes of adult-onset (LADA) has been proposed for this category of subjects. Studies have demonstrated that patients with autoimmune diabetes, characterized by the presence of glutamic decarboxylase autoantibodies display a different clinical phenotype from classical type 2 diabetes without glutamic decarboxylase autoantibodies. This subset of phenotypic type 2 diabetes subjects with islet autoantibodies tend to have sulphonylurea failure and need insulin treatment earlier in the disease process. Diagnosing LADA at an initial stage will be important so that insulin can be initiated earlier, facilitating improved glycemic control sooner as well as the preservation of residual beta-cell function in adult-onset autoimmune diabetes. Because of differences in dietary habits, environmental factors, and phenotypic characteristics between European and Asian populations, there may be heterogeneity in the prevalence and other characteristics of LADA in these two populations.

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A study of non-obese diabetes mellitus in adults in a tertiary care hospital in Kerala, India

Cited by 11 publications

References 9 publications

Hypoglycemic and hypolipidemic effects of Aerva lanata (Linn.) on alloxan induced diabetic rats

Hypoglycemic and hypolipidemic effects of Aerva lanata (Linn.) on alloxan induced diabetic rats

Latent Autoimmune Diabetes in Adults (LADA): The Prevalent Form of Adult-Onset Autoimmune Diabetes in a Region of India

Latent autoimmune diabetes in adults (LADA) in Asian and European populations

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