The compressed air energy storage system has a better energy density, while the widely used hydraulic one is superior in power performance. Therefore, they are suitable for different hybrid vehicles, which require a comparative study on the performances and vehicle applicability of the broad pressure energy storage system layouts. In this paper, an integrated mathematical model of four basic pressure layouts is presented for characteristic analysis and applicability discussion. Results show that the open volume layout achieves the best power performance with the flow specific power of 13.92 MJ/m3, thus it is suitable for heavy hybrid trucks and mobile machinery. The open mass layout achieves the best energy performance with the energy density of 124.35 MJ/m3, which can be used in light new energy passenger vehicles. And the performance of the closed volume layout is close to the open volume layout with the flow specific power of 9.78 MJ/m3, so it could be applied to middle and light hybrid trucks. This research provides a basis for the hybrid method of pressure energy storage system layouts for vehicles, and could be applied in the design and research of non-electric hybrid vehicles in the near future.