Occupational Health and Safety (OSH) is defined as the science of anticipation, recognition, evaluation and control of hazards arising from the workplace that could impair the wellbeing of workers. It is a cross-disciplinary area that is concerned with protecting the safety, health and welfare of people engaged in employment or work. It is against this background that the research project was carried out to find the effect of selected Occupational health and Safety management practices on job satisfaction of employees in University Campuses in Nakuru Town, Kenya. The study was guided by the following objectives: to determine the effect of selected welfare management practices on job satisfaction, to determine the effect of emergency management practices on job satisfaction, to determine the effect of workplace environment practices on employee job satisfaction and to determine the combined effect of welfare management practices, emergency management practices and workplace management practices on employee job satisfaction. The target population comprised of 258 samples of non-teaching staff, in all the University Campuses situated in Nakuru. Census was conducted to select data. Data was collected using questionnaires; Data analysis for all the objectives was done using multiple regression analysis, and descriptive statistics such as frequencies, tables, charts, and graphs. Hypothesis testing in all the objectives was done using Pearson's correlation and regression analysis. The study is of importance to the management of university campuses in establishing the effect of selected occupational health and safety management practices on job satisfaction of employees in University campuses in Nakuru Town, Kenya. The findings revealed that the practice of occupational health and safety management practices leads to improved job satisfaction among employees. The study recommends that Universities should invest in occupational health and safety issues that concern employees. Areas for further study identified include challenges in the implementation of occupational health and safety management practices on organizational work environment.