A study of onychomycosis in Krishna district of Andhra Pradesh, India

Harika, Dusi Ratn; Usharani, Anaparthy

doi:10.7241/ourd.20154.105

Cited by 6 publications

(5 citation statements)

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“…The DLSO was the most prevalent clinical pattern, followed by TDO. This result is in line with those reported by Neupane et al [ 31 ] and Harika and Usharani [ 32 ].…”

Section: Discussionsupporting

confidence: 94%

Pestalotioid fungi: A rare agent of onychomycosis among agriculture workers

Borgohain¹,

Barua²,

Mahanta³

et al. 2020

CMM

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Background and Purpose: Pestalotioid fungi are ubiquitous environmental molds that have received considerable attention in recent times not only because of their role as a plant pathogen but also owing to their high frequency of retrieval from human diseases. Regarding this, the present study was conducted to investigate onychomycosis caused by pestalotioid fungi, commonly considered important phytopathogens causing grey blight disease in Camellia sinensis. Materials and Methods: A total of 122 agriculture workers were enrolled from Assam, India. Direct microscopic examination was carried out using 40% KOH to determine the presence of any fungal element. Further processing of the specimens for the isolation of fungi was performed using the standard protocol. In addition, the keratinolytic potential of the isolates was evaluated by means of the in vitro hair perforation test. Results: Out of 103 culture-positive samples, non-dermatophyte and dermatophyte molds constituted 82.52% (n=85) and 6.79% (n=7) of the samples, followed by yeasts (n=1, 0.9%) and sterile hyphae (n=10, 9.7%). With regard to the isolated non-dermatophyte molds (82.69%), 4 cases belonged to pestalotioid fungi, such as Neopestalotiopsis piceana (n=1), Pestalotiopsis species (n=1), and Pseudopestalotiopsis theae (n=2). The keratinolytic activity of Pestalotiopsis species showed perforation by disrupting the hair cortex; furthermore, macroconidia were found to be present inside the human hair. Conclusion: A high rate of NDM isolation may be attributed to constant exposure to adverse environmental and occupational hazards. This study highlighted the importance of “pestalotioid fungi” as the rare etiologic agent of onychomycosis. Another remarkable finding was the keratinolytic potential of Pestalotiopsis species, which is unique in this study.

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“…The DLSO was the most prevalent clinical pattern, followed by TDO. This result is in line with those reported by Neupane et al [ 31 ] and Harika and Usharani [ 32 ].…”

Section: Discussionsupporting

confidence: 94%

Pestalotioid fungi: A rare agent of onychomycosis among agriculture workers

Borgohain¹,

Barua²,

Mahanta³

et al. 2020

CMM

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“…The finding is similar to studies done by Bhatia et al [24] and Debbarma et al [25]. While in several other Indian studies, T. rubrum was elicited as the commonest dermatophyte [14,26].…”

Section: Discussionsupporting

confidence: 90%

“…Our study revealed presence of fungal elements in 66.22% samples on direct KOH mount examination. This finding was lower than the results of various researchers [14,19,20] who reported mycological positivity of 81.8%, 75.23% and 82.35% respectively while this may be considered higher when compared with other studies [8,15] showing mycological positivity of 34% and 24.8%, respectively. In the present study, culture proven onychomycosis was present in 59.46% patients and this is nearly concordant with the studies conducted by Grover et al [21] and Kaur et al [22] showing culture positivity 62.7%, 60%, and 60.2%, respectively.…”

Section: Discussioncontrasting

confidence: 80%

“…Some studies have reported that onychomycosis is more prevalent in women because of their more involvement in wet work [11][12][13]. However, in our study, we have observed male preponderance (64.86%) which could be due to their increased outdoor activities and occupation related injuries which make them more vulnerable to trauma and subsequent fungal infections [6,[13][14][15].…”

Section: Discussioncontrasting

confidence: 65%

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Evaluation of mycological profile of onychomycosis in a tertiary care centre in Bareilly

Agarwal¹,

Prakash²,

Garg³

et al. 2021

J Med sci Res.

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Onychomycosis is a chronic fungal infection of nails which is not associated with significant morbidity and mortality but it can have negative impact on patient's emotional, social and occupational functioning. The affected nail can also serve as a chronic reservoir and can communicate the fungal infection to family members this makes onychomycosis an important public health problem. Treatment regimen and duration depends on the etiological agent. So, for the timely initiation of appropriate and effective treatment knowledge of etiological agents causing onychomycosis is required. This study was conducted to improve the knowledge of demographic and mycological profile of onychomycosis in Bareilly region. 74 nail specimens of suspected onychomycosis were evaluated clinically, KOH examination and fungal culture was done. Onychomycosis was present in 59.46% by culture and /or KOH examination. Fingernails and toenails were infected in 24.32% and 41.89% respectively and remaining 6.75% had both. Principal causative agents were dermatophytes (43.47%) with Trichophyton mentagrophytes being the most common (19.56%). In 15 (32.60%) cases, candida species and in 11 (23.91%) cases non-dermatophyte moulds have been isolated as the sole causative agent. This study demonstrated dermatophytes as the main agents causing onychomycosis in our region, as well as proves the importance of performing direct examination and culture in diagnosis of onychomycosis.

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“…Some studies like Ratna et al, Lone et al have shown greater male preponderance than female. 11,12 In most of the studies, dermatophytes are the most encountered organisms in onychomycosis. But in our study the predominant pathogen was Candida species (46.15%), of which 8 (15.38%) were Candida albicans and Non-albicans Candida accounted for 16 cases (30.76%).…”

Section: Discussionmentioning

confidence: 99%

A Study on the Pattern of Fungi Causing Onychomycosis in a Tertiary Care Hospital in Imphal

Chongtham¹,

Athokpam²,

Singh³

2018

jemds

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BACKGROUND Onychomycosis is a fungal infection of the nails. It is caused by dermatophytes, non-dermatophytes and yeasts. In spite of improved personal hygiene and living condition, it continues to persist and poses a major clinical challenge regarding its treatment due to its chronicity. The present study was conducted to identify the fungi causing onychomycosis in our region. MATERIALS AND METHODS This descriptive study was carried out in the Department of Microbiology at a tertiary healthcare centre in Manipur from August 2016 to August 2017. A total of 166 cases of clinically diagnosed cases of onychomycosis were taken up for study. After disinfecting the nails with 70% alcohol, collected nail samples were subjected to 20% KOH and culture was done on Sabouraud's Dextrose Agar (SDA) with chloramphenicol. Identification of the isolates was done by microscopic and macroscopic examination. RESULTS Out of 166 samples KOH is positive in 54 samples (32.54%), of which culture is positive in 30 samples (18.07%) and 24 is culture negative (14.45%). Total culture positivity is seen in 52 samples (31.32%), of which 30 samples (18.07%) is KOH positive and 22 samples (13.25%) is KOH negative. Females are predominantly affected (64.45%). F: M is 1.8: 1. Most affected age group is 21-30 yrs. (30.12%). Candida species are the commonest species isolated (46.15%) and non-albicans Candida are more predominant (30.76%) followed by dermatophytes (28.84%). Trichophyton rubrum is the commonest dermatophyte isolated (15.38%). CONCLUSION The study showed the genus Candida as the main pathogen causing onychomycosis in our region. So, clinical onychomycosis should be confirmed both by KOH and fungal culture to prescribe specific antifungal drugs for optimal outcome.

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A study of onychomycosis in Krishna district of Andhra Pradesh, India

Cited by 6 publications

References 0 publications

Pestalotioid fungi: A rare agent of onychomycosis among agriculture workers

Pestalotioid fungi: A rare agent of onychomycosis among agriculture workers

Evaluation of mycological profile of onychomycosis in a tertiary care centre in Bareilly

A Study on the Pattern of Fungi Causing Onychomycosis in a Tertiary Care Hospital in Imphal

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