2020
DOI: 10.1186/s12871-020-00984-1
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A study of optimal concentration range and time window of sevoflurane preconditioning for brain protection in MCAO rats

Abstract: Background: Sevoflurane preconditioning improves brain function in MCAO rats, and there are several methods for determining appropriate concentration and time windows for preconditioning. This study investigated the brain protective effects with a single sevoflurane preconditioning at different concentrations and different time windows on MCAO rats. Methods: Adult Sprague-dawley rats were randomly assigned to 14 groups. The rats in the sevoflurane preconditioning group inhaled 0.5 MAC, 1.0 MAC, and 1.3 MAC sev… Show more

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Cited by 3 publications
(1 citation statement)
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“…Antibiotics were used to prevent incision infection in each group during the procedure. After the CRF rats were anesthetized, as described in a previous study [ 14 ], a nylon thread was prepared, and the external and common carotid arteries were ligated using a silk thread. The prepared nylon cord was then inserted along the common carotid artery into the left internal carotid artery, the vascular clamp was released, the threaded plug was advanced to obstruct the ipsilateral middle cerebral artery, and the threaded plug was fixed above the incision of the left common carotid artery to complete the modeling of MCAO in rats.…”
Section: Methodsmentioning
confidence: 99%
“…Antibiotics were used to prevent incision infection in each group during the procedure. After the CRF rats were anesthetized, as described in a previous study [ 14 ], a nylon thread was prepared, and the external and common carotid arteries were ligated using a silk thread. The prepared nylon cord was then inserted along the common carotid artery into the left internal carotid artery, the vascular clamp was released, the threaded plug was advanced to obstruct the ipsilateral middle cerebral artery, and the threaded plug was fixed above the incision of the left common carotid artery to complete the modeling of MCAO in rats.…”
Section: Methodsmentioning
confidence: 99%