A study of perinatal outcome in preterm premature rupture of membranes

Poovathi, M; Yogalaksmi, Yogalaksmi

doi:10.18203/2320-1770.ijrcog20184967

Cited by 3 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sample size was calculated to be 139 considering a confidence level of 95% and taking an incidence of 10% for PPROM according to a previous study [4]. This was increased to 160 after considering a no response error of 15%.…”

Section: Methodsmentioning

confidence: 99%

Microbiome Diversity in Vaginal Fluid and Sensitivity Patterns in Preterm Premature Rupture of Membrane Cases

Ambalpady¹,

Samantroy²,

Mishra³

et al. 2022

Cureus

View full text Add to dashboard Cite

Introduction: Preterm premature rupture of membranes (PPROM) is spontaneous rupture of the fetal membranes before 37 completed weeks and before the onset of labor. PPROM occurs in 3% of all pregnancies and is responsible for approximately one-third of all preterm deliveries. It leads to increase in perinatal morbidity and mortality.Aim: The present study aimed to characterize the microbiome of vaginal fluid, which will be helpful in the selection of empiric antimicrobial therapy.

show abstract

Section: Methodsmentioning

confidence: 99%

Microbiome Diversity in Vaginal Fluid and Sensitivity Patterns in Preterm Premature Rupture of Membrane Cases

Ambalpady¹,

Samantroy²,

Mishra³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

Vaginal Bacteriological Pattern in Women with and without Preterm Prelabor Rupture of Membranes: A Comparative Study

Ghose,

Sravya,

Yogamoorthi

2023

Journal of South Asian Federation of Obstetrics and Gynaecology

View full text Add to dashboard Cite

Aim: This study was carried out to determine the vaginal bacteriological pattern along with their antibiotic susceptibility pattern in pregnant women with preterm prelabor rupture of membranes (PPROM) and to compare them with those without PPROM. The association of PPROM with neonatal and maternal complications was also studied. Materials and methods: This is an observational comparative study conducted in the year 2020 at a tertiary care teaching hospital located in Puducherry, India. The study included singleton pregnancies between 28 0/7 and 36 6/7 weeks of gestation with PPROM along with gestational age matched women without PPROM. A high vaginal swab was taken from all the candidates and sent for aerobic and anaerobic cultures. Organisms isolated along with their antibiotic susceptibility were noted and compared between the two groups. The software used was Statistical Package for the Social Sciences (SPSS) software, version 17.0 (IBM, Armonk, NY, USA). Results: This study demonstrated an overall incidence of PPROM of 2.8%. A positive culture rate of 35.2 and 9.3% was found among pregnant women with and without PPROM, which was found to be statistically significant. The commonest organism isolated was Escherichia coli (52.6%) which was 100% sensitive to imipenem and meropenem and 90% to cefoperazone-sulbactam and was found to be resistant to ampicillin in 90% of cases. Neonatal complications such as respiratory distress and sepsis were found to be significantly higher in the PPROM group than in the comparison group. Conclusion:There is no change in the vaginal microbiota in the last two decades, but the sensitivity pattern of antibiotics has changed considerably from the commonly used antibiotics to higher-generation antibiotics. This indicates indiscriminate use of antibiotics which has resulted in antibiotic resistance. This could be the probable reason for the increase in neonatal and maternal morbidity in PPROM. Clinical significance: The vaginal microbiological flora and the antibiotic susceptibility pattern of the population in this area was studied and a significant change was noted over the past years which will help in formulating newer and better treatment protocols in the future which would help in reducing neonatal and maternal morbidities.

show abstract

Fetomaternal Outcomes in Women Affected With Preterm Premature Rupture of Membranes: An Observational Study From a Tertiary Care Center in Eastern India

Pattnaik¹,

Panda²,

Jena³

et al. 2022

Cureus

View full text Add to dashboard Cite

Introduction: Preterm premature rupture of membranes (PPROM) is the spontaneous rupture of the fetal membranes before the completion of 37 weeks of pregnancy. PPROM occurs in 3% of pregnancies. Methodology: This prospective observational study was conducted between September 2019 and March 2021, involving 150 antenatal patients attending our outpatient department or labor room. All pregnant women with a singleton pregnancy between 28 and 37 weeks of gestational age with PPROM were included in our study. Results: A total of 44% of women were admitted to the hospital within 6-11 hours of the onset of PPROM, while 34% of women were admitted within five hours and 15.33% were admitted within 12-23 hours of the onset of PPROM. The most common organisms isolated in high vaginal swabs were Enterococcus faecalis (18%), Escherichia coli (12%), Staphylococcus aureus (12.66%), Staphylococcus haemolyticus (6.66%), and Candida albicans (4.66%). Around 74.66% of women were delivered within 24 hours of the onset of PPROM, whereas only 2.6% of patients were delivered after 72 hours and the rest 34% were delivered between 25 and 72 hours. Of our study subjects, 10% were febrile, 4% were having urinary tract infections, 2.5% had postpartum hemorrhage, and 2% had chorioamnionitis. As far as neonatal morbidity and mortality are concerned, birth asphyxia and jaundice were seen in 12% of patients each, whereas septicemia was found in 4% of study subjects. Conclusion: Owing to the association of higher maternal and perinatal morbidity and mortality, cases, especially in the early PPROM group, should be strictly monitored for clinical and laboratory signs of chorioamnionitis while opting for conservative management.

show abstract

A study of perinatal outcome in preterm premature rupture of membranes

Cited by 3 publications

References 3 publications

Microbiome Diversity in Vaginal Fluid and Sensitivity Patterns in Preterm Premature Rupture of Membrane Cases

Microbiome Diversity in Vaginal Fluid and Sensitivity Patterns in Preterm Premature Rupture of Membrane Cases

Vaginal Bacteriological Pattern in Women with and without Preterm Prelabor Rupture of Membranes: A Comparative Study

Fetomaternal Outcomes in Women Affected With Preterm Premature Rupture of Membranes: An Observational Study From a Tertiary Care Center in Eastern India

Contact Info

Product

Resources

About