A study of postnatal growth of skeletal muscle in the rat

Chiakulas, John J.; Pauly, John E.

doi:10.1002/ar.1091520107

Cited by 90 publications

(24 citation statements)

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“…These results are similar to those reported for other organ systems in the rat, in which early development is due primarily to cell division, and secondarily to hypertrophy. Once cell number is established, further growth is achieved by an increase in cell size alone (10)(11)(12). In the present study, total cell number reached a plateau in group II animals at 15 wk, whereas the cell number of group I animals continued to increase throughout the study.…”

Section: Resultssupporting

confidence: 45%

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Effect of early nutrition on the development of rat epididymal fat pads: cellularity and metabolism

Knittle¹,

Hirsch²

1968

J. Clin. Invest.

383

125

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A B S T R A C T The effect of infantile nutritional levels on adipose tissue cellularity and metabolism was studied in two groups of Sprague-Dawley rats. Caloric intake was varied during the suckling period by manipulating litter size immediately after birth; however, all animals had free access to food after weaning. The epididymal fat pads of animals raised in small litters were heavier than those of their paired siblings raised in large litters. Initially, the differences in pad weight were accounted for primarily by differences in total cell number; however, at 20 wk both cell number and cell size contributed equally. The rate of glucose incorporation into CO2 and triglyceride during in vitro incubations was the same for both groups if expressed on a per cell basis; therefore total tissue incorporation was greater in animals with more cells. The results support the hypothesis that early nutritional experiences can effect permanent changes in the cell number and size of the epididymal fat depot and that total cell number is important in the total metabolism of this organ. These findings and the fact that extreme human obesity is accompanied by similar alterations in cellularity and metabolism indicate that early nutritional experiences should be studied further as a guide to the etiology of obesity in man.A preliminary report of these studies was presented at

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Section: Resultssupporting

confidence: 45%

“…Studies of the growth and development of a variety of organs in the rat tend to support this hypothesis, since most organ systems show similar developmental patterns (10)(11)(12). Early in life there is a rapid increase in cell number which then reaches a plateau at varying time intervals, depending upon the organ under study.…”

Section: Discussionmentioning

confidence: 99%

Effect of early nutrition on the development of rat epididymal fat pads: cellularity and metabolism

Knittle¹,

Hirsch²

1968

J. Clin. Invest.

383

125

View full text Add to dashboard Cite

show abstract

“…The red muscle fiber may also change to muscle fiber of another type during the maturation. The number of fibers in rat muscles increases in the initial 3 weeks of postnatal life (Chiakulas and Pauly, 1965). The red muscle fibers may be inferior in numbers of new muscle fibers, which develop in postnatal life.…”

Section: Discussionmentioning

confidence: 99%

Histo- and cytochemistry of acetylcholinesterase activity at the myotendinous junction in skeletal muscles of rats.

Nishikawa

1981

Acta Histochem. Cytochem

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“…Morpugo [1895] reported an increase of 23% in the albino rats within the first 16 days of post-natal life. In rats [Chiakulas and Pauley, 1965;Sting/, 1972;Rayne and Crawford, 1975] and mice [ Goldspink, 1962], an increase was reported within the first 21 days of post natal life. In the marsupials [Setonix brachyrus, Austra lian quookka; Bridge and Allbrook, 1970], an increase was reported for the first 100 days of post-natal life.…”

Section: Introductionmentioning

confidence: 99%

Loss of type I fibres in canine pectineus muscle hypotrophy

Ihemelandu¹

1980

Cells Tissues Organs

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The total number of fibres, as well as, the number of fibres per fibre type were determined by the indirect fibre-counting method in 32 pectineus muscles from 16 dogs of mixed sexes. Eight pairs of muscles from 8 dogs were judged to be hypotrophic, while the other 8 pairs from another 8 dogs were judged to be normal. The hypotrophic muscles had extremely small muscle fibres, particularly type II fibres. They also had apparently higher percentages of type II muscle fibres within a section. The apparently higher percentage of type II fibres usually observed in the histochemical examination of the sections of hypotrophic pectineus muscles did not result from failure of type II fibres to transform to type I fibres. It was rather due to too few type I fibres being present in these muscles as compared to the normal muscles. It was not because there were more type II fibres present in them than in the normal muscles. The fewer type I fibres resulted most likely from loss of already differentiated type I fibres. The loss may be of neural origin.

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A study of postnatal growth of skeletal muscle in the rat

Cited by 90 publications

References 1 publication

Effect of early nutrition on the development of rat epididymal fat pads: cellularity and metabolism

Effect of early nutrition on the development of rat epididymal fat pads: cellularity and metabolism

Histo- and cytochemistry of acetylcholinesterase activity at the myotendinous junction in skeletal muscles of rats.

Loss of type I fibres in canine pectineus muscle hypotrophy

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