A Study of Resistance to Calcification of Bovine Jugular Veins with Coatings Deposited from Solutions in Carbonic Acid

Chashchin, I. S.; Petlenko, Antonina A.; Zaitsev, I. L.; Bakuleva, Natalia P.

doi:10.1134/s0012501621010012

Cited by 1 publication

(2 citation statements)

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“…The obtained acellular tissue showed no decrease in mechanical strength ( Sawada et al, 2008 ). Bakuleva and her team have recently modified this technique and applied it to BJV tissues ( Chaschin et al, 2020 ; Chashchin et al, 2021 ). They developed a “hybrid” treatment which consisted of a short exposure to the standard detergent solution (1% v/v sodium dodecylsulphate) followed by an exposure to the scCO2 with Tween-80, in order to achieve complete decellularization and to preserve the ECM components (such as collagen and elastin) and structures.…”

Section: Modified Treatments and Designsmentioning

confidence: 99%

“…Chashchin et al deposited chitosan from carbonic acid solution to decellularized BJVC, endowing the conduit a smooth intima surface and resistance to calcification. Meanwhile, the coating was also found to have significantly improved the strength and the elasticity of the decellularized conduit ( Chaschin et al, 2020 ; Chashchin et al, 2021 ). Krasilnikova et al applied globular chitosan, which had better diffusion and tissue-penetration characteristics than linear chitosan, to both cellular and acellular BJVCs.…”

Section: Modified Treatments and Designsmentioning

confidence: 99%

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Current development of bovine jugular vein conduit for right ventricular outflow tract reconstruction

Xie

Tan³

et al. 2022

Front. Bioeng. Biotechnol.

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Right ventricular outflow tract (RVOT) reconstruction is a common surgical method to treat congenital cardiac lesions, and bovine jugular vein conduit (BJVC) has become a prevalent candidate of prosthetic material for this procedure since 1999. Although many clinical studies have shown encouraging results on BJVCs, complications such as stenosis, aneurysmal dilatation, valve insufficiency, and infective endocarditis revealed in other clinical outcomes still remain problematic. This review describes the underlying mechanisms causing respective complications, and summarizes the current technological development that may address those causative factors. Novel crosslinking agents, decellularization techniques, conduit coatings, and physical reinforcement materials have improved the performances of BJVCs. The authors expect that the breakthroughs in the clinical application of BJVC may come from new genetic research findings and advanced characterization apparatuses and bioreactors, and are optimistic that the BJVC will in the future provide sophisticated therapies for next-generation RVOT reconstruction.

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Section: Modified Treatments and Designsmentioning

confidence: 99%

Section: Modified Treatments and Designsmentioning

confidence: 99%