A Study of Sensitivity of the Sustained Attention to Response Task in Patients With Schizophrenia

Chan, Raymond C. K.; Chen, E Y H; Cheung, Eric F.C.; Chen, R Y L; Cheung, H. K.

doi:10.1080/13854040490507208

Cited by 26 publications

(28 citation statements)

References 29 publications

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“…Once again, it is not sure whether similar relationship could be generalized to a different classification of neurological soft signs in schizophrenia. Nevertheless, studies adopting either the CNI [6], [22], [28], [34], [38], [45] or NES [4], [7], [15], [17], [19] have shown impressive sensitivity and discriminating power as a comprehensive neurological soft signs battery, and thus, suggest a valid classification of either approach. More importantly, the same structural and measurement models derived from the assessment of both patients and healthy volunteers provide strong support for the validity of the current observations.…”

Section: Discussionmentioning

confidence: 99%

“…The Sustained Attention to Response Task (SART) [44] is a computer test during which participants respond with a key press to the occurrence of a target stimulus (digit) while inhibiting/withholding the response to the non-target digit “3”. This test has been demonstrated to capture sustained attention and disinhibition in clinical samples including schizophrenia [45]. The modified version of the Wisconsin Card Sorting Test (MCST) [46] was used to assess switching and flexibility.…”

Section: Methodsmentioning

confidence: 99%

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Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design

Chan

Wang

et al. 2009

PLoS ONE

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BackgroundNeurological soft signs and neurocognitive impairments have long been considered important features of schizophrenia. Previous correlational studies have suggested that there is a significant relationship between neurological soft signs and neurocognitive functions. The purpose of the current study was to examine the underlying relationships between these two distinct constructs with structural equation modeling (SEM).Methods118 patients with schizophrenia and 160 healthy controls were recruited for the current study. The abridged version of the Cambridge Neurological Inventory (CNI) and a set of neurocognitive function tests were administered to all participants. SEM was then conducted independently in these two samples to examine the relationships between neurological soft signs and neurocognitive functions.ResultsBoth the measurement and structural models showed that the models fit well to the data in both patients and healthy controls. The structural equations also showed that there were modest to moderate associations among neurological soft signs, executive attention, verbal memory, and visual memory, while the healthy controls showed more limited associations.ConclusionsThe current findings indicate that motor coordination, sensory integration, and disinhibition contribute to the latent construct of neurological soft signs, whereas the subset of neurocognitive function tests contribute to the latent constructs of executive attention, verbal memory, and visual memory in the present sample. Greater evidence of neurological soft signs is associated with more severe impairment of executive attention and memory functions. Clinical and theoretical implications of the model findings are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design

Chan

Wang

et al. 2009

PLoS ONE

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“…The score derived from the SET was the number of sub-tasks attempted minus the number of rule-breaks. The SET has not been used with a depressed sample, but appears to be a sensitive indicator of executive function in studies with schizophrenia and brain injury (Evans et al 1997 ;Chan et al 2004). …”

Section: Controlled Oral Word Association Testmentioning

confidence: 99%

The relationship between cognitive function and clinical and functional outcomes in major depressive disorder

2008

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“…8,28 The SART is a computer test in which 225 single digits are presented to the test taker over 4.3 minutes. Each digit is presented for 250 msec, followed by a 900-msec mask.…”

Section: Executive Function Testsmentioning

confidence: 99%

Different aspects of dysexecutive syndrome in patients with moyamoya disease and its clinical subtypes

Fang

Hua

Zhang

et al. 2016

JNS

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obJective Dysexecutive syndrome is common in patients with moyamoya disease (MMD), a chronic cerebrovascular disease that is characterized by stenosis of the bilateral internal carotid arteries and progressive collateral revascularization, and MMD can be classified as ischemic or hemorrhagic according to the disease presentation and history. In this study, the authors aimed to determine which aspects of executive function are impaired in patients with MMD, in addition to the specific dysexecutive functions present among its clinical subtypes and the mechanisms underlying dysexecutive function in these patients. [SART]) to 49 patients with MMD and 47 IQ-, age-, education-, and social status-matched healthy controls. The dysexecutive questionnaire (DEX) was also used to assess participants' subjective feelings about their executive function. A total of 39 of the patients were evaluated by CT perfusion (CTP) before the assessments were performed, and the correlations among the performances of the patients on the above tests with the parameters of cerebral blood volume, cerebral blood flow (CBF), mean transit time (MTT), and time-to-peak (TTP) in the frontal lobes of these patients were also analyzed. results Many aspects of executive function in the patients with MMD were significantly poorer than those in the healthy controls, and the patients performed particularly poorer on the VF test, HSCT, N-back test, and SART. The patients with hemorrhagic MMD exhibited worse executive inhibition, executive processing, and semantic inhibition compared with those with ischemic MMD, but the latter group presented a worse working memory and poorer sustained attention. There were no significant differences in the DEX scores between the patients with MMD and healthy controls. The other findings were as follows: CBF was significantly positively correlated with the number correct on part B of the HSCT (r = 0.481, p = 0.01) and accuracy on the 0-back task of the N-back (r = 0.346, p = 0.031); MTT was significantly positively correlated with accuracy on the 2-back task of the N-back (r = 0.349, p = 0.034) and factor 5 of the DEX (r = 0.359, p = 0.032); and TTP was significantly positively correlated with the number correct on part B of the HSCT (r = 0.402, p = 0.034) and the 1-back reaction time of the N-back (r = 0.356, p = 0.026). coNclusioNs The patients with MMD exhibited impairments in semantic inhibition, executive processing, working memory, and sustained attention, but they were not aware of these deficits. Moreover, differences in dysexecutive function existed between the different subtypes of MMD. Hypoperfusion of the frontal lobe may be related to working memory and semantic inhibition impairments in patients with MMD.

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A Study of Sensitivity of the Sustained Attention to Response Task in Patients With Schizophrenia

Cited by 26 publications

References 29 publications

Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design

Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design

The relationship between cognitive function and clinical and functional outcomes in major depressive disorder

Different aspects of dysexecutive syndrome in patients with moyamoya disease and its clinical subtypes

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