A Study of Stripping Voltammetric Behaviour of Cefadroxil Antibiotic in the Presence of Cu (II) and its Determination in Pharmaceutical Formulation

Abstract

Square-wave voltammetry was used to explore the adsorption property of cefadroxil complex with copper ions on the hanging mercury drop electrode (HMDE). By employing the adsorptive stripping voltammetric approach, a sensitive electroanalytical method for the quantitative analysis of cefadroxil antibiotic was achieved. A welldeveloped voltammetric peak was obtained in pH 10 Britton-Robinson buffer (B-R buffer) at -650 mV. The cyclic voltammetric studies indicated that the reduction process was irreversible and primarily controlled by adsorption. An investigation of the variation of adsorptive voltammetric peak current with supporting electrolyte, pH, accumulation time, accumulation potential, scan rate, pulse amplitude, SW frequency, working electrode area and convection rate has resulted in the recognition of optimal experimental conditions for cefadroxil analysis. The studied electroanalytical signal showed a linear response for cefadroxil in the concentration range 6×10 -7 -2×10 -6 mol L -1 (r = 0.999). A limit of detection of 2×10 -9 mol L -1 with relative standard deviation of 2.783 RSD% and mean recovery of 99% was obtained. Possible interferences by several substances usually present in pharmaceutical formulation were also evaluated. The analytical quantification of cefadroxil in commercially available pharmaceutical formulation was performed and compared with data from HPLC technique.

Analytical Comparison of Cefadroxil Determination by Square Wave Adsorptive Stripping Voltammetric and Spectrophotometric Methods

“…Submit your Manuscript | www.austinpublishinggroup.com of CFDL. It's due to their ease of use, repeatability, great sensitivity, and quick analytical results [35]. Cefadroxil has electroactive groups that can be readily reduced on the surface of mercury drop electrodes and hanging mercury drop electrodes [36,37].…”

Voltammetric Analysis of Montelukast Sodium in Commercial Tablet and Biological Samples Using the Hanging Mercury Drop Electrode

“…It certainly constitutes the most useful technique for a preliminary determination of the redox properties of a given species [5]. There have been many reviews devoted to emphasize and illustrate the wide spectrum and scope of AdSV applications and potentialities in the analysis of metal ions [6][7][8][9][10], food analysis [11], organic analytes [12,13] and pharmaceutical drugs and biomedical compounds [14][15][16][17][18][19][20][21][22][23][24][25]. Montelukast (trade names Singulair and Montelo-10) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.…”