Death by suicide occurs in a disproportionate percentage of individuals with anorexia nervosa (AN), with a standardized mortality ratio indicating a 57-fold greater risk of death from suicide relative to an age-matched cohort. Longitudinal studies indicate impaired social functioning increases risk for fatal outcomes, while social impairment persists following recovery. Study of social cognition in AN may elucidate impaired processes that may influence therapeutic efficacy. Symptoms of autism spectrum disorders (ASD) are overrepresented in those who evidence a chronic course. Relative to that in AN, social information processing in ASD is well characterized and may inform systematic study in AN. This article (a) reviews impaired interpersonal processes in AN, (b) compares the phenotype of AN with that of ASD, (c) highlights deficits of social cognitive disturbance in ASD relative to AN, and (d) proposes a new framework to understand the interaction of individuals with AN with their social context.Keywords: anorexia nervosa, social cognition, autism, interpersonal functioning, eating disorders Individuals with anorexia nervosa (AN) have a nearly 12-fold greater risk of death from all causes and a 57-fold greater risk of death from suicide relative to their age-matched peers (Keel et al., 2003). Such troubling statistics speak to the incapacitating, perplexing, and isolating nature of AN, a severe psychiatric illness that negatively impacts the biological, emotional, and psychosocial functioning of both the affected individual and her or his family (Harris & Barraclough, 1998;Treasure, Whitaker, Whitney, & Schmidt, 2005). In fact, AN exacts a toll on the family reported to exceed that experienced by families with a child with a severe psychiatric disorder such as schizophrenia . Although guiding epidemiologic data are currently lacking, there has been increasing concern regarding several notable trends: (a) an upsurge of AN in both younger and older ages than has been previously reported Johnson, Cohen, Kasen, & Brook, 2006;Marcus & Kalarchian, 2003), (b) increased incidence in minority groups hitherto thought protected (Decaluwe, Braet, & Fairburn, 2003;Tanofsky-Kraff et al., 2003), and (c) recent published reports of extensive illness burden among family members Treasure, Whitaker, Whitney, & Schmidt, 2005;Whitney & Eisler, 2005). Such patterns highlight the broad impact of these illnesses and underscore the urgency of alternative approaches to illness management.While advances have been made in the treatment of adolescents with a relatively short duration of illness (Lock & le Grange, 2005), progress in the treatment of adults with AN remains limited, at best (W. S. Agras et al., 2004;Kaplan, 2002). Of note, a report issued by the National Institute of Mental Health (W. S. Agras et al., 2004) emphasized the absence of innovative treatment approaches over the past several decades. This conclusion was recently echoed in an evidence-based review calling for novel intervention strategies that target core biological...