A Study of the Antibodies of the H'O'I-B Complex with Special Reference to Their Occurrence and Notation

Abstract

Studies on seventy-five sera containing antibodies of the H‘0’I-B complex together with a survey of studies by other workers show that many of the antibodies formerly called anti-‘0’ and some of those called anti-H are in fact reacting with a joint product of the H and I genes. The serological specificities of these antibodies were shown by agglutination tests with cells of known H and I or B and I status, together with the use of neutralisation and absorption techniques. These tests revealed that many of the sera contain mixtures of antibody specificities. The occurrence of anti-H-HI antibodies is probably associated with pregnancy. An H notation based on that proposed by Wiener et al. is recommended for use in the classification of these antibodies.

Cold Autoimmune Hemolytic Anemia with Auto-Anti-Ai Specificity: 51Chromium Survival Studies

“…A few have specificity for a joint product of ABO-I gene interaction, IH, IB, and IA, called HI, BI, AI by some authors. sup (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) These cold autoantibodies react preferentially with O, B, or A adult cells, respectively, but do not react with cord cells of like ABO type. They are IgM antibodies that are not inhibitable by soluble A, B, or H substance.…”