A study of the biologic falsely positive reactions for syphilis in children

Miller, J. Lowry; Meyer, Paul G.; Parrott, Norman A.; Hill, Justina H.

doi:10.1016/s0022-3476(60)80082-0

Cited by 11 publications

(4 citation statements)

References 3 publications

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“…His assay was the basis of the still widely applied non-treponemal tests, the Venereal Diseases Research Laboratory (VDRL) test and the rapid plasma reagin (RPR) test, both based on this same principle. Between 56 and 66% of infants born to mothers with positive syphilis serologic findings are positive for nontreponemal syphilis tests [39][40][41]. One of the diagnostic criteria sometimes used to diagnose CS is the detection of non-treponemal antibodies by the VDRL or the RPR test.…”

Section: Laboratory Diagnosismentioning

confidence: 99%

A review of diagnostic tests for congenital syphilis in newborns

Herremans

Kortbeek

Notermans

2010

Eur J Clin Microbiol Infect Dis

108

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Congenital syphilis (CS) can occur when a mother is inadequately treated or not treated at all for an active Treponema pallidum infection. Symptoms of CS are often subtle and non-specific, and it is estimated that up to 60% of affected infants are asymptomatic at birth, making the diagnosis dependent on laboratory findings. Despite decades of experience with CS, problems still arise in its diagnosis because laboratory test results for children at risk for CS can be inconclusive and no single diagnostic test can be used to diagnose CS. The development of diagnostic tests such as enzyme immunoassays, immunoblotting and polymerase chain reaction (PCR) has increased the sensitivity and specificity of diagnoses, but the detection of specific IgM is currently the most sensitive serological method, and the presence of specific IgM should be considered as evidence of a congenital T. pallidum infection. Suspected cases can also be confirmed or excluded by serial post-partum tests of antibody kinetics. The authors note strongly that it is considered unethical not to treat a baby at risk of contracting CS, even without a definitive diagnosis. In this review, we describe the various microbiological methods-and their shortcomings-used in the laboratory diagnosis of CS.

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Section: Laboratory Diagnosismentioning

confidence: 99%

A review of diagnostic tests for congenital syphilis in newborns

Herremans

Kortbeek

Notermans

2010

Eur J Clin Microbiol Infect Dis

108

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“…Because only limited studies or anecdotal information on the association between cord blood and maternal blood syphilis sérologies were available, cord blood, maternal serum, and newborn serum syphilis serology results were reviewed at this institution to determine if (1) a rapid plasma reagin test (RPR; Becton Dickinson Microbiology Systems, Cockeysville, Md) performed on cord blood identified newborns with congenital syphilis, (2) the ratio of newborn cord blood RPR to maternal blood RPR was helpful in the diagnosis of congenital syphilis, and (3) an RPR performed on newborn serum was superior to an RPR performed on cord blood.…”

mentioning

confidence: 99%

Comparison of Maternal and Newborn Serologic Tests for Syphilis

Rawstron

Bromberg²

1991

Arch Pediatr Adolesc Med

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“…Similar remarks m ay be made in the two cases of the seropositive siblings described by Leonhardt (1964). The study of Miller et al (1960), consisting of 400 children and their mothers, included 73 children whose m others are referred to as BFP reactors. Of these 73 children, 13 are referred to as B FP reactors, 9 " persistently" .…”

Section: Discussionmentioning

confidence: 99%