A study of the different parameters in acute and chronic Budd–Chiari syndrome

Niknam, Ramin; Hajizadegan, Nemattellah; Mohammadkarimi, Vahid; Mahmoudi, Laleh

doi:10.1186/s43066-020-00058-4

Cited by 3 publications

(6 citation statements)

References 16 publications

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“…The most common etiologies include hereditary thrombophilic disorders such as protein C and S, factor V Leiden, and antithrombin III (ATIII) deficiency. Acquired disorders, including myeloproliferative disorders, antiphospholipid syndrome, and paroxysmal nocturnal hemoglobinuria (PNH), are considered to be relatively less common [ 5 , 11 , 12 ]. Celiac disease, Behcet's disease, sarcoidosis, immunoallergic vasculitis, and granulomatosis are potential systemic prothrombotic causative factors of BCS.…”

Section: Discussionmentioning

confidence: 99%

“…Depending on the stage of the disease, BCS can be classified as acute or chronic. These two classifications differ in clinical presentations, treatment modalities, and prognostic factors [ 5 ]. The acute onset of BCS is characterized by hepatic dysfunction, abdominal pain, ascites, and, at times, renal failure [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…These two classifications differ in clinical presentations, treatment modalities, and prognostic factors [ 5 ]. The acute onset of BCS is characterized by hepatic dysfunction, abdominal pain, ascites, and, at times, renal failure [ 5 , 6 ]. Chronic presentation of the disease accompanied by portal hypertension is seen more often [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Rare Case of Budd-Chiari Syndrome in a Young Child: A Diagnostic Conundrum

Timsaal¹,

Ali²,

Malik³

et al. 2021

Cureus

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Budd-Chiari syndrome (BCS) is an uncommon vascular disorder in which venous thrombosis prevents the venous outflow of the liver. The obstruction is primarily at the level of hepatic veins and inferior vena cava.Here, we present a case of a two-and-a-half-year-old male child who presented with complaints of abdominal distension for two months and fever and watery diarrhea for one month. Physical examination showed the patient was anemic with palmar erythema. He was started on an empirical treatment of cefotaxime, metronidazole, and amikacin. Sensitivity and culture reports for blood and urine samples were negative, but abdominal computed tomography (CT) scan showed characteristic findings for BCS with caudate lobe hypertrophy. After the symptomatic treatment of the patient, a liver transplant was suggested as a last resort.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rare Case of Budd-Chiari Syndrome in a Young Child: A Diagnostic Conundrum

Timsaal¹,

Ali²,

Malik³

et al. 2021

Cureus

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“…Majority of BCS patients present with the classic triad of abdominal pain especially in the upper right quadrant presenting in 61% of cases, ascites presenting in 83% of cases, and hepatomegaly presenting in 67% of cases[ 6 , 72 ]. The classic triad may form suddenly in acute cases (< 6 months), or progressively in chronic cases (> 6 months)[ 73 ]. These symptoms may or may not be accompanied by a wide range of nonspecific symptoms.…”

Section: Diagnosis Of Budd-chiari Syndromementioning

confidence: 99%

Budd-Chiari syndrome in myeloproliferative neoplasms: A review of literature

Găman¹,

Cozma²,

Manan³

et al. 2023

World J Clin Oncol

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Myeloproliferative neoplasms (MPNs) are defined as clonal disorders of the hematopoietic stem cell in which an exaggerated production of terminally differentiated myeloid cells occurs. Classical, Philadelphia-negative MPNs, i.e. , polycythemia vera, essential thrombocythemia and primary myelofibrosis, exhibit a propensity towards the development of thrombotic complications that can occur in unusual sites, e.g. , portal, splanchnic or hepatic veins, the placenta or cerebral sinuses. The pathogenesis of thrombotic events in MPNs is complex and requires an intricate mechanism involving endothelial injury, stasis, elevated leukocyte adhesion, integrins, neutrophil extracellular traps, somatic mutations ( e.g. , the V617F point mutation in the JAK2 gene), microparticles, circulating endothelial cells, and other factors, to name a few. Herein, we review the available data on Budd-Chiari syndrome in Philadelphia-negative MPNs, with a particular focus on its epidemiology, pathogenesis, histopathology, risk factors, classification, clinical presentation, diagnosis, and management.

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“…Gene mutations in factor V Leiden and factor II have been recorded in ~25 and 5% of patients with BCS, respectively ( 4 ). Oral contraceptive use has also been identified as a risk factor for BCS ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

A rare encounter with two cases of Budd‑Chiari syndrome in the Emergency Department: A case report

et al. 2022

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Budd-Chiari syndrome (BCS) is a rare disorder clinically characterized by abdominal pain, hepatomegaly and ascites. The condition is often related to thrombosis of the hepatic veins or the terminal portion of the inferior vena cava. A myeloproliferative disorder is the most identified underlying prothrombotic risk factor, although almost one-half of affected patients are now recognized as having multiple underlying prothrombotic risk factors. Doppler ultrasound may be enough to confirm the diagnosis of BCS; however, computed tomography or magnetic resonance imaging is often employed. Anticoagulant therapy is the cornerstone of BCS treatment, but most patients also need additional treatment strategies. Most patients with BCS are now treated by endovascular intervention, which has improved survival rate in those afflicted by this disease. The long-term course of the disease can be complicated by progression or recurrence of the underlying myeloproliferative disorder. The present study reports the cases of two patients with BCS with the aim of alerting healthcare workers in Emergency Departments of this less common diagnosis in patients presenting with frequent complaints of abdominal pain.

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A study of the different parameters in acute and chronic Budd–Chiari syndrome

Cited by 3 publications

References 16 publications

Rare Case of Budd-Chiari Syndrome in a Young Child: A Diagnostic Conundrum

Rare Case of Budd-Chiari Syndrome in a Young Child: A Diagnostic Conundrum

Budd-Chiari syndrome in myeloproliferative neoplasms: A review of literature

A rare encounter with two cases of Budd‑Chiari syndrome in the Emergency Department: A case report

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