A Study of the Effect of an Anion Exchange Resin on Gastric and Duodenal Secretions and Gastric Emptying 1

Wirts, C. Wilmer; Rehfuss, Martin E.; Delserone, B. A.; Wass, Beatrice

doi:10.1172/jci102232

Cited by 15 publications

(3 citation statements)

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“…The resin Amberlite® IRP58, manufactured by Rohm and Haas, was of this type and was used in the early treatment of gastric acidity in ulcer patients [17, 18], and later as a carrier for anionic drugs such as para-aminosalicylic acid [55]. The total ion exchange capacity of this type of resin is high, around 10 mEq/g of dried resin in the chloride form, in keeping with the close proximity of its polyamine exchange sites.…”

Section: Characteristics Of Individual Resinsmentioning

confidence: 99%

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Sevelamer and Other Anion-Exchange Resins in the Prevention and Treatment of Hyperphosphataemia in Chronic Renal Failure

Wrong

Harland²

2007

Nephron Physiol

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Sevelamer, or more precisely ‘sevelamer hydrochloride’, is a weakly basic anion-exchange resin in the chloride form that was introduced in 1997 for the treatment of the hyperphosphataemia of patients with end-stage renal failure, usually those on long-term haemodialysis. The rationale for this therapy was that sevelamer would sequester phosphate within the gastrointestinal tract, so preventing its absorption and enhancing its faecal excretion. Over the succeeding years, large numbers of patients have been treated with sevelamer, and it has fulfilled expectations in helping to control the hyperphosphataemia of end-stage renal failure. However, it is only one of many anion-exchange resins that could be used for this purpose, some of which are currently available for clinical use and are much less costly than sevelamer. Theoretical considerations suggest that some of these other resins might be at least as efficient as sevelamer in sequestering phosphate in the gastrointestinal tract. Neither sevelamer, nor any of these other agents, has been submitted to a proper metabolic balance study to measure the amount of phosphate sequestered by the resin in the bowel, and without this information it is impossible to judge which is the ideal resin for this purpose.

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Section: Characteristics Of Individual Resinsmentioning

confidence: 99%

“…In clinical medicine they have been used in the treatment of gastric acidity [17, 18], in attempts to relieve metabolic acidosis [19, 20], to remove bile anions from the body in the management of hyperlipidaemia and cholestasis [21, 22], and to sequester intestinal oxalate in the management of enteric hyperoxaluria [23]. …”

Section: Introductionmentioning

confidence: 99%

Sevelamer and Other Anion-Exchange Resins in the Prevention and Treatment of Hyperphosphataemia in Chronic Renal Failure

Wrong

Harland²

2007

Nephron Physiol

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“…Leum and Macuga, and Kreps ( 173) have reported that an acid cation exchanger catalyzes the production of an aliphatic ether from isoolefins and alcohols. The acid properties and exchange properties of several inorganic catalysts have been described (30, 296), BIOLOGICAL APPLICATIONS Continued studies on the use of anion exchangers for the treatment of ulcers have been made by Weiss, Espansal, and Weiss (303) and Wirts, Rehfass, Delserone, and Wass (311). Sullivan and Martin (286) have found the use of ion exchange resins to be of use in decreasing the acute toxicity of atropine.…”

Section: Catalysismentioning

confidence: 99%