A Study of the Effect of &amp;lt;i&amp;gt;Citrus aurantium&amp;lt;/i&amp;gt; L. Essential Oil on Anxiety and Its Interaction with GABAergic Pathways in Male Mice

Khosravi, Maryam; Khakpour, Shahrzad; Adibi, Leila; Jahromy, Mahsa Hadipour

doi:10.4236/jbbs.2014.410046

Cited by 12 publications

(6 citation statements)

References 10 publications

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“…The same group evaluated the co-administration effects of C. aurantium L. with diazepam [29]. They found that C. aurantium L. essential oil (i.p.)…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models

et al. 2015

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Abstract:The clinical efficacy of standardized essential oils (such as Lavender officinalis), in treating anxiety disorders strongly suggests that these natural products are an important candidate source for new anxiolytic drugs. A systematic review of essential oils, their bioactive constituents, and anxiolytic-like activity is conducted. The essential oil with the best profile is Lavendula angustifolia, which has already been tested in controlled clinical trials with positive results. Citrus aurantium using different routes of administration also showed significant effects in several animal models, and was corroborated by different research groups. Other promising essential oils are Citrus sinensis and bergamot oil, which showed certain clinical anxiolytic actions; along with Achillea wilhemsii, Alpinia zerumbet, Citrus aurantium, and Spiranthera odoratissima, which, like Lavendula angustifolia, appear to exert anxiolytic-like effects without GABA/benzodiazepine activity, thus differing in their mechanisms of action from the benzodiazepines. The anxiolytic activity of 25 compounds commonly found in essential oils is also discussed.

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“…The same group evaluated the co-administration effects of C. aurantium L. with diazepam [29]. They found that C. aurantium L. essential oil (i.p.)…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models

et al. 2015

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“…Although diazepam increased open arms exploration (percentage of time spent and percentage of entries), coadministration with Citrus aurantium reduced the anxiolytic effect of diazepam. Flumazenil did not alter the effect of Citrus aurantium ; however, authors suggest that Citrus aurantium L. may exert an anxiolytic-like effect acting as partial agonist at the GABA-A receptor/benzodiazepine site [52]. Preclinical antianxiety effects of Citrus aurantium are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Clinical Pharmacology of Citrus aurantium and Citrus sinensis for the Treatment of Anxiety

Mannucci

Calapai

Cardia

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Objective The aim of this review is to analyze preclinical and clinical studies investigating the anxiety effects of Citrus aurantium or Citrus sinensis essential oils (EOs). Design The bibliographic research was made on the major scientific databases. Analysis included only articles written in English and published on peer-reviewed scientific journals describing preclinical experiments and clinical trials carried out to investigate the antianxiety effects of Citrus aurantium or Citrus sinensis EOs on anxiety disorders. Clinical studies reporting the antianxiety effects of products containing Citrus aurantium or Citrus sinensis EOs in combination with other active substances, including medicinal plants, were excluded. Nine clinical studies fulfilled the criteria adopted for analysis. Results Data show that Citrus aurantium or Citrus sinensis EOs produce anxiolytic effects both in preclinical experiments and in different clinical conditions. Citrus aurantium EO aromatherapy reduced anxiety level in the great part of stress conditions studied (subjects affected by chronic myeloid leukemia and preoperative patients) except for a sample of patients subjected to colonoscopy. Exposition to Citrus sinensis EO in clinical studies shows to be positive in reducing anxiety level in patients waiting for dental treatment as well as in healthy volunteers submitted to an anxiogenic situation. Conclusions Overview of clinical trials conducted with Citrus aurantium or Citrus sinensis on people with anxiety showed that inhalation or oral administration of Citrus aurantium and inhalation of Citrus sinensis can exert beneficial effects on anxiety; however, because of incomplete accuracy in the reporting of methodology, further more complete clinical studies are warranted.

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“…During the experiment it was observed that the animals submitted to the elevated cross test, both those treated with the control drug and those treated with the essential oil, showed a significant increase in the length of stay in the open arms. When the essential oil was applied simultaneously with diazepam, the results were even more significant, indicating a reduction in anxiety (Khosravi et al, 2014). Furthermore, additional studies have shown that essential oil can decrease or increase the responsiveness of nociceptors.…”

Section: Activity Of Neroli Essential Oil On the Cnsmentioning

confidence: 96%

Potential action on the central nervous system of neroli oil extracted from Citrus aurantium

Borba

Fernandes

Campos

et al. 2021

RSD

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The essential oil from C. aurantium has been widely studied due to its potential anxiolytic action on several receptors in the Central Nervous System (CNS). Although it presents variations in its phytochemical composition depending on its origin, we can highlight that many compounds remain present, such as linalool that demonstrated antagonistic activity on glutamatergic receptors, possible inhibitory action of noradrenaline and serotonin receptors, besides the ability to activate GABA receptors in association with some flavonoids present in the oil. It is globally known that the underlying pathology called anxiety influences worldwide as an antecedent of conflicting psychological and physical disorders, which are associated with various neuronal disorders. In this regard, the oil extracted from C. aurantium flowers shows a potential therapeutic application for the treatment of anxiety disorders. However, more studies are needed to elucidate its complete role on the CNS and to verify and prove its safety and efficacy profile.

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A Study of the Effect of <i>Citrus aurantium</i> L. Essential Oil on Anxiety and Its Interaction with GABAergic Pathways in Male Mice

Cited by 12 publications

References 10 publications

A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models

A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models

Clinical Pharmacology of Citrus aurantium and Citrus sinensis for the Treatment of Anxiety

Potential action on the central nervous system of neroli oil extracted from Citrus aurantium

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