A Study of the Effect of Vitamin C and of an Antihistaminic Drug on Gingival Hyperplasia Occurring in Patients Receiving Diphenylhydantoin Sodium

Rose, JD; Buffaloe, William J.; Dunham, Richard M.

doi:10.1056/nejm196111092651904

Cited by 4 publications

(2 citation statements)

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“…Other researchers conducted matched, prospective RCT's. The first of these, a 1961 study of vitamin C and antihistamines on gingival hyperplasia among patients receiving the anti-seizure medication phenytoin, was analogous to the study by Amberson et al (1931), a matched-cluster randomization study (Rose et al 1961).…”

Section: Medicine and Public Healthmentioning

confidence: 99%

Pair-Matching with Random Allocation in Prospective Controlled Trials: The Evolution of a Novel Design in Criminology and Medicine, 1926-2021

Welsh,

Podolsky,

Zane

2023

CrimRxiv

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Objectives Pair-matching with random allocation in prospective controlled trials represents a novel and highly rigorous design. First use of the design can be traced to medicine (in 1926) and criminology and the social sciences more generally (in 1935). Beginning with these trials, we examine the subsequent history of matchedpair RCTs (randomized controlled trials), and related attention to stratification prior to randomization, in both criminology and medicine over almost a century to illustrate shared interest in the design's advantages and disadvantages. MethodsWe draw upon a wide range of historical and contemporary sources, including historical archives and writings on the first trials in criminology and medicine, prior reviews of RCTs and matched-pair RCTs, and searches of selected databases. ResultsThe first trials draw attention to key factors that remain central to contemporary use, including concerns about covariate imbalance when randomization is used on its own, potential to improve study power when matching is effective, and the ability to deal with differential attrition in follow-ups. The evolution of the design also shows that the single most important application of matched-pair RCTs is when the units are clusters or places. ConclusionsOver the 20th and 21st centuries, criminology and medicine have continued to wrestle with methodologies to most efficiently and robustly compare like with like. Both, in this setting, have turned to matched-pair randomization, though less often than its advocates would like. It is this and other shared interests between criminology/social sciences and medicine/public health, including a movement toward evidence-based policy and practice, that help us reimagine possibilities for advancing knowledge and improving public policy.

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Section: Medicine and Public Healthmentioning

confidence: 99%

Pair-Matching with Random Allocation in Prospective Controlled Trials: The Evolution of a Novel Design in Criminology and Medicine, 1926-2021

Welsh,

Podolsky,

Zane

2023

CrimRxiv

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“…Hence, the general assumption has evolved that bacterial plaque and associated gingival inflammation is a critical factor in development of gingival overgrowth. This premise led to attempts at alleviation of the condition by antimicrobial and antihistamine treatment including tooth brushing with pastes containing chiorhexidine gluconate (Russell & Bay 1978) and urea peroxide (Shupik & Cohen 1976), topical treatment with phenylephrine hydrochloride (Pernsteiner & Ash 1977), and systemic administration of diphenylhydramine (Rose, Buffaloe & Dunham 1961). Therapy, such as the above, has not proven useful with subjects already having gingival overgrowth.…”

Section: Introductionmentioning

confidence: 99%

Microbial flora and clinical parameters in phenytoin associated gingival overgrowth

Smith

Wilson

Germaine

et al. 1983

J of Periodontal Research

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The effect of phenytoin therapy on periodontal indices, plaque microbiology, and gingival overgrowth was studied. Plaque, gingivitis, and calculus indices and pocket depth were recorded for anterior and posterior teeth of 89 subjects partitioned into 5 groups, a control group, and 4 groups of patients receiving phenytoin therapy with differing severity of gingival overgrowth. A survey of the major oral microorganisms present in marginal plaque was also done. The clinical indices increased with increasing severity of overgrowth. Patients with no or minimal overgrowth had clinical indices equal to or less than those of controls. The proportions of the major oral genera in marginal plaque samples from the groups were similar except for the patients with the most severe gingival overgrowth (mentally retarded and institutionalized). The microbe proportions from neither anterior nor posterior sites had a distinct relationship to severity of gingival overgrowth. Furthermore, no differences were found between clinical parameters or plaque microbiology at the anterior sites of patients who had greater anterior than posterior overgrowth. More frequent Correlations occurred among clinical parameters than among microbial percentages or between microbial percentages and clinical indices. This study does not support a specific marginal plaque etiology for phenytoin associated gingival overgrowth.

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Pair-matching with random allocation in prospective controlled trials: the evolution of a novel design in criminology and medicine, 1926–2021

2022

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A Study of the Effect of Vitamin C and of an Antihistaminic Drug on Gingival Hyperplasia Occurring in Patients Receiving Diphenylhydantoin Sodium

Cited by 4 publications

References 5 publications

Pair-Matching with Random Allocation in Prospective Controlled Trials: The Evolution of a Novel Design in Criminology and Medicine, 1926-2021

Pair-Matching with Random Allocation in Prospective Controlled Trials: The Evolution of a Novel Design in Criminology and Medicine, 1926-2021

Microbial flora and clinical parameters in phenytoin associated gingival overgrowth

Pair-matching with random allocation in prospective controlled trials: the evolution of a novel design in criminology and medicine, 1926–2021

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