A Study of the Electrokinetic and Stability Properties of Nitrofurantoin Suspensions. II: Flocculation and Redispersion Properties as Compared with Theoretical Interaction Energy Curves

Delgado, A.V.; Gallardo, V.; Parera, Anna Rigol; González‐Caballero, F.

doi:10.1002/jps.2600790812

Cited by 15 publications

(2 citation statements)

References 10 publications

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“…The flocculation ratio, F, was the quantity chosen for the characterization of the stability. This is defined as 100 (Vs/V 0 ), where V 0 is the initial total volume of the suspension [19] and Vs is the volume of sedimented solids. The redispersibility was ascertained by visual inspection of the suspensions after placing them for 2 min in an Branson 5200E4 ultrasonic bath (USA) operating at 40 kHz and with a sonic power of 100W.…”

Section: Stability Studymentioning

confidence: 99%

Spectrophotometric and chromatographic determination of omeprazole in pharmaceutical formulations

Gallardo

López-Viota

Sierra

et al. 2009

Pharmaceutical Development and Technology

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The purpose of this study was to determine the stability of the pH sensitive drug, omeprazole, within different solid oral pharmaceutical formulations and to determine whether the addition of antacid and surfactant agents, at varying concentrations, influenced drug stability and release. Spectrophotometric and chromatographic techniques were used for evaluation purposes, giving good results concerning linearity, precision and specificity within the range of concentrations used in this study. However, the results show that the degradation products of omeprazole interfere with spectrophotometric evaluation, making this technique insufficiently selective for omeprazole. On the other hand, liquid chromotography proved to be more sensitive, accurate and precise. Additionally, in an attempt to improve the administration form of the drug, an extemporaneous suspension was designed, which after evaluation proved to be a satisfactory administration vehicle. The best formulation of omeprazole studied is: omeprazole: 0.5%; corn starch 34.2%; aluminum hydroxide 26%; magnesium hydroxide 13%; simple syrup 24.8%; SDS 1%.

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Section: Stability Studymentioning

confidence: 99%

Spectrophotometric and chromatographic determination of omeprazole in pharmaceutical formulations

Gallardo

López-Viota

Sierra

et al. 2009

Pharmaceutical Development and Technology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Such studies should permit a prediction of the conditions in which the particles will remain stable in suspension or rather coagulate or adhere to other solidsmainly of biological interest-with which they might come into contact. Following procedures already applied to other suspensions of drugs, 12,13 polymers, 14 or biologically important solids, 15,16 zeta () potential data will be necessary to show the electrical contribution to particle-particle interactions. The thermodynamic characterization of the interface should yield additional information about van der Waals forces and acid/base interactions.…”

Section: Introductionmentioning

confidence: 99%