A study of the hepatoprotective effect of Plantago psyllium L. seed extract against Carbon tetrachloride induced hepatic injury in rats

Abouzied, Mekky M.; Mahmoud, Shaymaa M; Wahid, Ahmed; Ahmed, Amr E.; Okasha, Ahmed M; Soliman, Hanan A.; Thagfan, Sultan S. Al; Attia, Eman Zekry

doi:10.32725/jab.2020.006

Cited by 5 publications

(6 citation statements)

References 30 publications

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“…TNF-α is a marker for inflammatory illness and it is a pro-inflammatory cytokine that has a critical role in modifying many physiological events as well as inflammation. P. psyllium extract successfully reduced CCl4-induced inflammation and hence TNF-α expression, indicating its healing effect on liver cells via the controlling of cytokine expression and the underlying inflammatory process [ 104 ]. Aucubin (a type of iridoid glycoside) and Lantamajoside exhibited anti-inflammatory properties through the inhibitory effect of TPA (12-o-tetradecanoylphorbol-13-acetate) [ 105 ] and arachidonic acid metabolism, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Another study showed that animals who received psyllium extract at variable doses showed no signs of toxicity, morbidity or changes in animal behaviour. Analysis of serum renal and hepatic biomarkers showed that a dose of up to 1000 mg/kg of the extract was safe without any side effects [ 104 ].…”

Section: Discussionmentioning

confidence: 99%

“…They concluded that Psyllium seed extract was comparable to the standard hepatoprotective drug silymarin. They observed that indomethacin caused degenerative changes and cell necrosis in the liver’s cells and decreased hepatic microsomal cytochrome P-450 and prostaglandin [ 104 ]. Jumaily and Al Azawi [ 22 ] concluded that liver and renal damage from paracetamol-induced hepato-nephrotoxicity can be prevented, and pure lignan was better than partial lignan in rabbits.…”

Section: Discussionmentioning

confidence: 99%

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Therapeutic Efficacy of a Formulation Prepared with Linum usitatissimum L., Plantago ovata Forssk., and Honey on Uncomplicated Pelvic Inflammatory Disease Analyzed with Machine Learning Techniques

et al. 2023

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A single-blind double-dummy randomized study was conducted in diagnosed patients (n = 66) to compare the efficacy of Linseeds (Linum usitatissimum L.), Psyllium (Plantago ovata Forssk.), and honey in uncomplicated pelvic inflammatory disease (uPID) with standard drugs using experimental and computational analysis. The pessary group received placebo capsules orally twice daily plus a per vaginum cotton pessary of powder from linseeds and psyllium seeds, each weighing 3 gm, with honey (5 mL) at bedtime. The standard group received 100 mg of doxycycline twice daily and 400 mg of metronidazole TID orally plus a placebo cotton pessary per vaginum at bedtime for 14 days. The primary outcomes were clinical features of uPID (vaginal discharge, lower abdominal pain (LAP), low backache (LBA), and pelvic tenderness. The secondary outcomes included leucocytes (WBCs) in vaginal discharge on saline microscopy and the SF-12 health questionnaire. In addition, we also classified both (pessary and standard) groups using machine learning models such as Decision Tree (DT), Random Forest (RF), Logistic Regression (LR), and AdaBoost (AB). The pessary group showed a higher percentage reduction than the standard group in abnormal vaginal discharge (87.05% vs. 77.94%), Visual Analogue Scale (VAS)-LAP (80.57% vs. 77.09%), VAS-LBA (74.19% vs. 68.54%), McCormack pain scale (McPS) score for pelvic tenderness (75.39% vs. 67.81%), WBC count of vaginal discharge (87.09% vs. 83.41%) and improvement in SF-12 HRQoL score (94.25% vs. 86.81%). Additionally, our DT 5-fold model achieved the maximum accuracy (61.80%) in the classification. We propose that the pessary group is cost-effective, safer, and more effective as standard drugs for treating uPID and improving the HRQoL of women. Aucubin, Plantamajoside, Herbacetin, secoisolariciresinol diglucoside, Secoisolariciresinol Monoglucoside, and other various natural bioactive molecules of psyllium and linseeds have beneficial effects as they possess anti-inflammatory, antioxidant, antimicrobial, and immunomodulatory properties. The anticipated research work is be a better alternative treatment for genital infections.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Therapeutic Efficacy of a Formulation Prepared with Linum usitatissimum L., Plantago ovata Forssk., and Honey on Uncomplicated Pelvic Inflammatory Disease Analyzed with Machine Learning Techniques

et al. 2023

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“…So, it may act as free radical scavenger and may be used to cure various disorders. Mekky and coworkers investigated antioxidant activity of psyllium seeds to protect against CCl 4 (free radical) induced-hepatotoxicity experimentally [23]. It also has enhanced endogenous antioxidant capability of hepatic tissue and inhibited lipid peroxidation.…”

Section: In Hepatic Diseasesmentioning

confidence: 99%

Psyllium: A Source of Dietary Fiber

Agrawal¹

2022

Dietary Fibers

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Dietary fiber is commonly known as roughage. Fibers are mostly present in vegetables, whole grain, nuts, legumes, and fruits. This is an indigestible part of the food obtained by plants. It includes polysaccharides such as cellulose, hemicellulose, pectic substances, mucilages, gums and lignin as well. Dietary fiber has beneficial physiological effect on health, so it is included in daily diet to decrease occurrence of several diseases. In this sequence, this chapter describes about the dietary fiber, psyllium commonly known as Isabgol which is prepared from the seed of the Plantago ovata Forsk (Psyllium ispaghula). Psyllium is hydrophilic mucilloid, has the capacity to absorb water and increases in volume while absorbing water. Psyllium consists of mixed viscous polysaccharide in which about 35% soluble and 65% insoluble polysaccharides (cellulose, hemicellulose, and lignin) are present. This can be used as gelling, food thickener, emulsifying and stabilizing agents in some food products. Psyllium is a natural biopolymer which has high quantity of hemicelluloses consist of xylan backbone connected with arabinose, galacturonic acid and rhamnose units. Since last many years it is being used as therapeutic agent in several diseases like chronic constipation, inflammation of mucous membrane of GIT tract, duodenal ulcers, piles or diarrohoea etc. It may be source of renewable and biodegradable polymer.

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“…Other studies, in turn, would suggest potential applications of the hoary plantain that are waiting to be explored. For example, a hepatoprotective action was observed for the defatted aqueous methanolic extract obtained from the leaves of P. major (effect attributed to verbascoside) [ 70 ], P. ovata husk mucilage [ 78 ] and seed aqueous extract [ 79 ], P. asiatica seeds polysaccharide fraction [ 80 ], P. psyllium seeds ethanolic extract (for which the total phenolics and total flavonoids contents were determined as 16.17 mg gallic acid equivalents/g dried weight, respectively 1.9 mg rutin equivalents/g dried weight) [ 81 ] and P. albicans leaves aqueous extract (total phenolics content 592.75 mg gallic acid equivalents/g, total flavonoids content 116.7 mg catechin equivalents/g [ 82 ], in several hepatic damage models, Table 3 ). Considering the variety of extracts and fractions used, the results would suggest a hepatoprotective potential for the P. media, also.…”

Section: Plantago Media L Future Perspectivesmentioning

confidence: 99%

Plantago media L.—Explored and Potential Applications of an Underutilized Plant

Fierăscu

Orţan

et al. 2021

Plants

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The search of valuable natural compounds should be directed towards alternative vegetal resources, and to the re-discovery of underutilized plants. Belonging to the Plantaginaceae family, the hoary plantain (Plantago media L.) represents one of the lesser studied species from the Plantago genus. The literature study revealed the under-utilization of the hoary plantain, a surprising aspect, considering its widespread. If the composition of Plantago media L. is rather well established, its applications are not nearly studied as for other Plantago species. The goal of the present paper is to summarize the findings regarding the applications of P. media, and, having as starting point the applications of related species, to propose new emerging areas of research, such as the biomedical applications validation through in vivo assays, and the evaluation of its potential towards industrial applications (i.e., development of food or personal care products), pisciculture or zootechny, phytoremediation and other environmental protection applications, or in the nanotechnology area (materials phytosynthesis). The present work constitutes not only a brief presentation of this plant’s present and potential applications, but also an invitation to research groups world-wide to explore the available vegetal resources.

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A study of the hepatoprotective effect of Plantago psyllium L. seed extract against Carbon tetrachloride induced hepatic injury in rats

Cited by 5 publications

References 30 publications

Therapeutic Efficacy of a Formulation Prepared with Linum usitatissimum L., Plantago ovata Forssk., and Honey on Uncomplicated Pelvic Inflammatory Disease Analyzed with Machine Learning Techniques

Therapeutic Efficacy of a Formulation Prepared with Linum usitatissimum L., Plantago ovata Forssk., and Honey on Uncomplicated Pelvic Inflammatory Disease Analyzed with Machine Learning Techniques

Psyllium: A Source of Dietary Fiber

Plantago media L.—Explored and Potential Applications of an Underutilized Plant

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