A study of the kinetics and mechanism of chromic acid oxidation of isosorbide, a chiral biomass-derived substrate, in aqueous perchlorate solution

“…The safe disposal of waste that is harmful to the environment is one of the most prominent challenges at the present time, especially with the technological and industrial development. − Medications or medical drugs are chemical substances used to detect, remedy, or avoid diseases in human, animals, and plants. − While medical drugs are fundamentally essential, they are foreign substances to the human body and must be eliminated after showing their medical role via the drug metabolism process in which drugs undergo a certain chemical reaction such as oxidation, reduction, hydrolysis, and so forth. Drug metabolism may transform drugs to medically effective, ineffective, or toxic materials that are excreted into the ecosystem and water sites. − Since the structures of these metabolites comprise complex organic compounds which can also stay in the environment for a long time without removal, these metabolites can be deliberated as dangerous pollutants. − Consequently, there is a huge interest to recognize efficient green treating methods or techniques for the removal or degradation of these materials to protect the ecosystem and human health. − …”

Section: Introductionmentioning

confidence: 99%

“… 14 − 16 Consequently, there is a huge interest to recognize efficient green treating methods or techniques for the removal or degradation of these materials to protect the ecosystem and human health. 17 − 20 …”

Section: Introductionmentioning

confidence: 99%

Effective Treatment Methodology for Environmental Safeguard Catalytic Degradation of Fluconazole by Permanganate Ions in Different Acidic Environments: Kinetics, Mechanistics, RSM, and DFT Modeling

Toghan,

Fawzy,

Alqarni

et al. 2024

ACS Omega

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In this paper, the degradation of fluconazole drug (Flz) was explored kinetically utilizing permanganate ion [MnO 4 − ] as an oxidant in different acidic environments, namely sulfuric and perchloric acids at various temperatures. Stoichiometry of the reactions between Flz and [MnO 4− ] in both acidic environments was attained to be 1.2 ± 0.07 mol. The kinetics of the degradation reactions in both cases were the same, being unit order regarding [MnO 4 − ], fewer than unit orders in [Flz], and fractional second orders in acid concentrations. The rate of oxidative degradation of fluconazole in H 2 SO 4 was higher than that in HClO 4 at the same investigational circumstances. The addition of small amounts of Mg 2+ and Zn 2+ enhanced the degradation rates. The activation quantities were evaluated and debated. The gained oxidation products were characterized using spot tests. A mechanistic approach for the fluconazole degradation was suggested. Finally, the rate law expressions were derived which were agreed with the acquired outcomes. The rates of degradation for various [Flz] were mathematically modeled using the response surface methodology (RSM). The RSM model's conclusions and the experimental findings are in agreement. The oxidative degradation mechanism of Flz using density functional theory (DFT) was performed. The fluconazole drug degrades in acidic settings, protecting both the environment and human health, according to a method that is easy to use, powerful, inexpensive, practical, affordable, and safe.

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“…2). The half order reaction as obtained with respect to the concentration of reductant is known to proceeds either by monomer-polymer equilibria with the monomeric species being the reactive form(Wilkins, 2002;Fawzy et al, 2017), or molecular dissociation(Berry et al, 1980;Onu et al, 2016). The redox reactions of first order dependence on [Fe(III)HEDTAOH2] have been reported(Buettner et al, 1983;Francis et al, 1985).…”

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confidence: 99%

Kinetics and mechanism of the reduction of n-(2-hydroxyethyl)ethylenediaminetriacetatoiron(III) complex by thioglycol in bicarbonate buffer medium

Nkole

Osunkwo

Onu

et al. 2018

IJAC

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The kinetics and mechanism of reduction of N-(2-hydroxyethyl) ethylenediaminetriacetatoiron (III) complex (hereafter [Fe(III)HEDTAOH2]) by thioglycol (hereafter RSH) has been studied spectrophotometrically in a bicarbonate buffer medium. The study was carried out under pseudo-first order conditions of an excess of thioglycol concentration at 28 ± 1℃, I = 0.44 mol dm-3 (KNO3) and λmax = 490 nm. The reaction is first order in [Fe(III)HEDTAOH2] and half order in [RSH] and a stoichiometric mole ratio of [Fe(III)HEDTAOH2]: RSH is 2:1. Reaction rates increased with increase in ionic strength (I) and dielectric constant (D) of the reaction medium of the reaction. The reaction displayed positive primary salt effect, which suggests the composition of activated complex are likely charged reactants ions. Test for possibility of an intermediate complex formation shows negative as Michaelis-Menten plot was linear with very negligible intercept. Based on the findings, outer-sphere mechanism is proposed for the reaction. The experimental rate law obtained is; - = k2 [Fe(III)HEDTAOH2][RSH]½

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A study of the kinetics and mechanism of chromic acid oxidation of isosorbide, a chiral biomass-derived substrate, in aqueous perchlorate solution

Cited by 8 publications

References 28 publications

Chemocatalytic value addition of glucose without carbon–carbon bond cleavage/formation reactions: an overview

Chemocatalytic value addition of glucose without carbon–carbon bond cleavage/formation reactions: an overview

Effective Treatment Methodology for Environmental Safeguard Catalytic Degradation of Fluconazole by Permanganate Ions in Different Acidic Environments: Kinetics, Mechanistics, RSM, and DFT Modeling

Kinetics and mechanism of the reduction of n-(2-hydroxyethyl)ethylenediaminetriacetatoiron(III) complex by thioglycol in bicarbonate buffer medium

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