A study of the neuroprotective role of Punica granatum and rosuvastatin in scopolamine induced cognitive deficit in rats

Fatima, Fariha; Rizvi, Dilshad Ali; Abidi, Afroz; Ahmad, Ali; Shukla, Pooja; Qadeer, Fardan; Srivastava, Karan

doi:10.18203/2319-2003.ijbcp20172747

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…As in other research, amnesia is induced using the scopolamine model (2.5 mg/kg) [31]. It has a central action and is a muscarinic cholinergic antagonist.…”

Section: Discussionmentioning

confidence: 96%

Effect of Curcumin and Coenzyme Q10 Alone and in Combination on Learning and Memory in an Animal Model of Alzheimer’s Disease

et al. 2023

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The most frequent neurodegenerative illness among senior people and the main cause of dementia is Alzheimer’s disease. The present dementia medications available only help with the symptoms of cognitive deficits and have several negative effects. The current study’s goal is to assess the effects of curcumin and coenzyme Q10, two herbal medicines, both separately and in combination, on learning and memory before comparing them to the industry standard drug. A total of 42 adult healthy Wistar rats were used in our study. In this experiment, rats were given daily doses of 2.5 mg/kg of body weight of scopolamine hydrobromide for 7 days to induce Alzheimer’s disease. On the eighth day, behavioural testing was conducted. Following testing, scopolamine and the test medications were given daily for the following 21 days. On days 29 and 30, behavioural testing was conducted once more, and then animals were slaughtered. Brain homogenate was produced for the estimation of molecular and biochemical markers. Curcumin has demonstrated a dose–response relationship, with a higher dose (200 mg/kg b.w. p.o.) being more effective than a lower dose (100 mg/kg b.w. p.o.). Similar to the greater dose of curcumin, coenzyme Q10 (200 mg/kg b.w. p.o.) has also been found to improve memory and learning. Higher doses of curcumin and coenzyme Q10 had more pronounced and meaningful effects. Acetylcholinesterase and TNF levels increased in scopolamine-induced memory impairment, but these effects were restored by the test medications, and improved by the combined therapy. These outcomes are comparable to those of the common medication memantine. As a result, we may infer from our results that curcumin at higher doses and its combination with coenzyme Q10 (200 mg/kg b.w. p.o.) have a significant impact on cognitive impairment in animal models of Alzheimer’s disease and can be utilised alone or as an add-on therapy for the condition.

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“…As in other research, amnesia is induced using the scopolamine model (2.5 mg/kg) [31]. It has a central action and is a muscarinic cholinergic antagonist.…”

Section: Discussionmentioning

confidence: 96%

Effect of Curcumin and Coenzyme Q10 Alone and in Combination on Learning and Memory in an Animal Model of Alzheimer’s Disease

et al. 2023

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“…Another study conducted by H. Ahmed et al, (2014) demonstrated that pomegranate seeds at dosages of 100 and 200 mg/kg exhibited cognitive-enhancing effects, potentially through the reduction of Amyloid-β Precursor (Aβ) aggregates in the hippocampus. Additionally, Fatima et al (2017), demonstrated that oral consumption of Punica granatum seeds at a dosage of 500 mg/kg showed ameliorating effects on scopolamine-induced cognitive dysfunction, particularly in the passive avoidance response.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Mood and Memory-enhancing Effects of Punicagranatum Seeds (Pomegranate)Extract using an Animal Model

2023

JJBS

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The research aimed to elucidate the neurological benefits of Punicagranatum seeds (Pomegranate), which have been traditionally touted for their therapeutic properties. To understand their impact, the study systematically examined the seeds' effects on key neurological functions: anxiety, depression, memory, and motor coordination. Through a series of experiments, the seeds were observed to significantly reduce anxiety levels, alleviate depressive symptoms, and enhance memory performance. The efficacy of these seeds might be attributed to their rich content of bioactive compounds, including isoflavones, triterpenes, and antioxidants. Since, there is an increasing demand for natural remedies and a shift towards holistic wellness, the potential therapeutic applications of Punicagranatum seeds cannot be understated. If these promising results can be consistently replicated in more extensive clinical trials, the seeds could be harnessed to develop innovative, natural treatments for neurological disorders.

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“…Another study exhibited that pomegranate extract (100 and 200 mg/kg) exerted cognitive‐enhancing effects possibly via the depletion of Aβ aggregates in the hippocampus (Ahmed et al, 2014 ). Furthermore, P. granatum juice (500 mg/kg oral) was shown to ameliorate passive avoidance response in scopolamine‐mediated cognition dysfunction (Fatima et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Punica granatum peel supplementation attenuates cognitive deficits and brain injury in rat by targeting the Nrf2‐HO‐1 pathway

Akbarian

Hosseini

Mirzavi

et al. 2022

Food Science & Nutrition

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The critical role of nutrition to prevent neurodegenerative disorders is well documented. Punica granatum fruit is identified as a highly nutritional food for alleviating various ailments. The ameliorating properties of P. granatum peel on memory dysfunction and the possible roles of oxidative stress, acetylcholinesterase (AchE), and nuclear factor erythroid 2‐related factor 2 (Nrf2)‐heme oxygenase (HO)‐1 pathway in the scopolamine‐treated rats were assessed. The hydroethanolic extract was standardized using high‐performance liquid chromatography (HPLC). The animal groups were as follows: Control, scopolamine (2 mg/kg), and treatment groups (the extract at doses of 200–800 mg/kg). The behavioral performance was evaluated using the Morris water maze (MWM) and passive avoidance equipment. Various biochemical parameters were then measured. Rats received the extract properly found on the platform location, indicated by a shorter traveling time and distance during 5 days of learning MWM. Moreover, the extract increased the delay and light time, while decreasing dark time and the frequency of entries to the dark in the passive avoidance test. The extract also exerted a significant increase in superoxide dismutase activity and thiol content, while decreasing AchE activity and lipid peroxidation in the brain of scopolamine‐injured rats. Our results demonstrated the neuroprotective effects of P. granatum peel in minimizing scopolamine injury possibly through targeting the Nrf2‐HO‐1 pathway.

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A study of the neuroprotective role of Punica granatum and rosuvastatin in scopolamine induced cognitive deficit in rats

Cited by 8 publications

References 12 publications

Effect of Curcumin and Coenzyme Q10 Alone and in Combination on Learning and Memory in an Animal Model of Alzheimer’s Disease

Effect of Curcumin and Coenzyme Q10 Alone and in Combination on Learning and Memory in an Animal Model of Alzheimer’s Disease

Evaluating the Mood and Memory-enhancing Effects of Punicagranatum Seeds (Pomegranate)Extract using an Animal Model

Punica granatum peel supplementation attenuates cognitive deficits and brain injury in rat by targeting the Nrf2‐HO‐1 pathway

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