A study of The Possible Protective Effects of Garlic Oil and Rosemary Extract Against Some Toxic effects of Acrylamid on Adult Male Albino Rats

Atwa, Asmaa Husseiny

doi:10.21608/zjfm.2019.13597.1031

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…In the other hand, our results in the present study is in contrast to that of Atwa et al [45] who revealed that administration of rosmarinus officinalis ( rosemary) extract resulted in a high significant increase i.e. improvement in activity of acetylcholinesteras enzyme in the brain tissue of rats treated with Acryl amide [45]. The role of the liver is not limited to its physiological functions but extends to other important ways of protecting against the risks and side effects of drugs and various chemicals that enter the body of the organism.…”

Section: Resultscontrasting

confidence: 99%

“…(0.5 ml solution/rat) for 4 weeks resulted in a significant reduction of acetylcholine esterase activity in all tested brain areas of adult male albino rats [44]. In the other hand, our results in the present study is in contrast to that of Atwa et al [45] who revealed that administration of rosmarinus officinalis ( rosemary) extract resulted in a high significant increase i.e. improvement in activity of acetylcholinesteras enzyme in the brain tissue of rats treated with Acryl amide [45].…”

Section: Resultscontrasting

confidence: 99%

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Pathogenic Effects of Ethion Residues and the Expected Protective Role of the Ethanolic Extract of Rosemary (Rosmarinus Officinalis L.) Leaves in Male Rats

Abdel‐Gawad¹,

Soliman

Taha³

et al. 2021

Egypt. J. Chem.

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Organophosphate insecticides (OPI) poisoning remains a major cause of morbidity and mortality in the third world countries. The continuous use of these pesticides tends to leave residues of these pesticides in agricultural crops, which in turn may harm people. The present study aimed to investigate the pathogenic effects of the "ethion" residues and the expected protective role of the ethanolic extract of rosemary (Rosmarinus officinalis L.) (EER), in adult male rats. Feeding animals with Maize containing ethion residues (4 mg/Kg) caused elevation in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) activities (P<0.01, P<0.001 and P<0.01), respectively. Whereas total protein (T.P) and albumin (ALB) were significantly decreased (P<0.01 and P<0.05), respectively. As well as, an elevation in serum creatinine and urea levels (P<0.01). Also, a significant (P<0.01) increase in cholesterol, triglyceride and low density lipoprotein (LDL) and a significant (P<0.001) decrease in high density lipoprotein (HDL) content as compared to the control were obtained. In addition a decrease in plasma acetyl cholinesterase (P<0.01). Decrease in glutathione (GSH) ( P<0.01 ) , Superoxide dismutase (SOD), ( P<0.05 ), catalase (CAT) P ( P<0.01 ) and an increase in Malondialdehyde (MDA) ( P<0.01 ) were observed in liver , kidney and brain tissues, respectively as compared with controls. Supplementation with ethanolic extract of rosemary leaves (EER), effectively relieved most of the ethion-induced alterations. The histological investigation strongly confirmed the highly protective effect of the EER in the tissues of selected organs. These findings suggest that rosemary is effective in improving both the function and structure of the examined organs through their potent antioxidant effect.

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Section: Resultscontrasting

confidence: 99%

Section: Resultscontrasting

confidence: 99%

Pathogenic Effects of Ethion Residues and the Expected Protective Role of the Ethanolic Extract of Rosemary (Rosmarinus Officinalis L.) Leaves in Male Rats

Abdel‐Gawad¹,

Soliman

Taha³

et al. 2021

Egypt. J. Chem.

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“…In the same study, it was emphasized that the GSH level decreased significantly in the cerebral homogenates of the rats treated with ACR compared to the regular control group, and the MDA content increased significantly, suggesting ACR-induced oxidative stress in the brain. Atwa Asmaa Husseiny et al mentioned in their study that light microscopic examination of brain sections in rats treated with 15 mg/kg acrylamide showed shrunken pyramidal cells surrounded by empty spaces (Atwa, 2020). Among other findings, apoptotic cells with small dark stained nuclei and acidophilic cytoplasm surrounded by space; dilated and clogged blood vessels were reported.…”

Section: Discussionmentioning

confidence: 94%

An investigation of histopathologic and morphometric effect of black carrot juice on acrylamid induced neurotoxicity

ESEN>¹,

Uçkun²,

Özkaya³

et al. 2021

J Exp Clin Med

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Acrylamide is an organic compound that is known to have neurotoxic influences. People have high exposure to its impacts because of its extensive uses in the industrial fields and its occurrence in foods. This situation has induced the scientific word to identify naturel components that may eliminate these neurotoxic effects. In this experimental study the influence of black carrot juice containing bioavailable flavonoids was researched on acrylamide neurotoxicity. In the study, laboratory rats were divided in to four groups. Group 1 rats were the control group. While the rats in Group 2 were administered acrylamide substance, the rats in Group 3 were supplemented with black carrot juice + acrylamide, and the rats in Group 4 were given black carrots juice only. At the experiment’s end, biochemical, histopathological, and histomorphometry analysis were performed on exanguned rats. Significant histopathological degenerations were observed in the acrylamide treated group. Despite a volumetric degrease in all brain regions examined histomorphometrically, this decrease was not statistically significant. The malondialdehyde and Glutathione S-transferase levels of the acrylamide group showed a significant increase compared to the control group. The glutathione, carboxylesterase and acetylcholinesterase levels were observed to increase in the acrylamide and black carrot applied group, compared to the acrylamide group. This study’s findings have revealed the black carrot’s healing effects on acrylamide neurotoxicity.

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“…Aly et al [22] noticed the protective effects of garlic and cinnamon oils on hepatocellular carcinoma in albino rats and found out that these natural oils have the ability to improve liver function and significantly improve the liver toxicity. Asmaa Husseiny Atwa [23] observed that garlic oil extract ameliorate the toxicity induced due to acrylamide exposure which was found to be toxic to the brain of rats. Dorrigiv et al [24] described garlic as an antidote or a protective agent against natural or chemical toxicities.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Garlic Oil Supplementation on Serum Sodium and Potassium Ions against Formaldehyde Induced Toxicity in Wistar Rats

Nihal,

Maheshwari,

Singh

2023

UPJOZ

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The present experimental study was designed to investigate the protective effect of garlic oil against formaldehyde vapor induced toxicity on serum electrolytes namely sodium (Na+) and potassium (K+). Twenty four male rats were randomly divided into three groups (control set 1, experimental set 2 and experimental set 3). The control set 1 was fed with standard food without any exposure and garlic oil supplementation while experimental set 2 was exposed to 6 ppm formaldehyde vapors for one hour daily for 30 days and experimental set 3 was given garlic oil supplementation (1 ml/100 g b. wt.) after exposure to 6 ppm formaldehyde vapors for one hour daily for 30 days. A highly significant increase in serum sodium ion level and a highly significant decrease in serum potassium ion level was observed respectively after exposure to formaldehyde vapors (P<0.01), while a significant decrease in serum sodium ion level (P<0.05) and a highly significant increase in serum potassium ion level has been noticed respectively after supplementation of garlic oil in comparison to formaldehyde vapor exposed rats (P<0.01). Therefore, it is concluded that garlic oil has shown positive potential to detoxify the toxic effect of formaldehyde inhalation on serum electrolytes sodium Na+ and potassium K+.

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A study of The Possible Protective Effects of Garlic Oil and Rosemary Extract Against Some Toxic effects of Acrylamid on Adult Male Albino Rats

Cited by 4 publications

References 18 publications

Pathogenic Effects of Ethion Residues and the Expected Protective Role of the Ethanolic Extract of Rosemary (Rosmarinus Officinalis L.) Leaves in Male Rats

Pathogenic Effects of Ethion Residues and the Expected Protective Role of the Ethanolic Extract of Rosemary (Rosmarinus Officinalis L.) Leaves in Male Rats

An investigation of histopathologic and morphometric effect of black carrot juice on acrylamid induced neurotoxicity

Protective Effect of Garlic Oil Supplementation on Serum Sodium and Potassium Ions against Formaldehyde Induced Toxicity in Wistar Rats

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