A study of the prevalence of methicillin-resistant Staphylococcus aureus in dermatology inpatients

Abstract

Background:Methicillin-resistant Staphylococcus aureus (MRSA) is a cause of increased morbidity and mortality in debilitated and immunocompromised patients.Aims and Objectives:To study the prevalence of MRSA among dermatology inpatients and elucidate its predisposing factors and antibiotic sensitivity pattern.Materials and Methods:This prospective study involved all the inpatients in the dermatology ward with suspected bacterial infections, both primary and secondary. Gram's stain, pus culture, and antibiotic sensitivity were the main tests done.Results:There were 61 patients in this study, with 36 males (59%) and 25 females (41%). The age group maximally affected was 41-50 years (21.6%). Vesiculobullous disorders (22, 36.1%) and eczemas (16, 26.2%) were the commonest dermatoses with secondary infection. Extremities (72.1%) and the trunk (26.2%) were the commonest sites involved. Diabetes mellitus (DM) was the commonest systemic illness (11.5%). Staphylococcus aureus was the commonest isolate, grown in 52 patients (85.2%) of whom 16 (30.80%) were MRSA positive. MRSA constituted 22.2% of the total bacterial isolates. All the MRSA isolates (100%) were resistant to cloxacillin and oxacillin, while all the isolates (100%) were sensitive to vancomycin and linezolid.Conclusions:The prevalence of MRSA in this study was high. It was most commonly seen in patients with vesiculobullous disorders. A high sensitivity of MRSA was found to amikacin. There was no relation between prolonged antibiotic therapy and MRSA in this study.

High frequency of methicillin-resistant Staphylococcus aureus in Peshawar Region of Pakistan

“…Similar findings were reported by various previous studies (Singh et al 2013 ; Sipahi et al 2013 ; Bhatt et al 2014 ; Chelliah et al 2014 ). In addition, all isolates were sensitive to linezolid which is in line with other studies (Sipahi et al 2013 ; Vijayamohan and Nair 2014 ). Linezolid has been approved by FDA for treating MRSA infection, so linezolid could be a possible alternative of vancomycin (Micek 2007 ).…”

Identification of the respiratory tract infection due to methicillin-resistant Staphylococcus aureus by TaqMan real-time PCR

“…Furthermore, a confirmatory test had been conducted using API-staph, a system allowing the suspected isolates to be rapidly identified at the species level. The distribution of MRSA among patients was consistent with previous results reported by Garoy et al;Vijayamohan and Nair [4,18]. S. aureus has become resistant to conventional and new antibiotics in recent years and represents a therapeutic challenge, because of this, the observation of the susceptibility pattern helps assess the possible difficulties of effective therapy [19].…”

Methicillin resistant Staphylococcus aureus infections in children: A prospective study

“…There was no resistance documented against vancomycin and linezolid in our study, as shown in other Indian studies. 3,5,18 Susceptibility to clindamycin (79.5%), cotrimoxazole (73.5%), amikacin (68.7%) and rifampicin (90.4%) were high, similar to the observations reported in other studies. 5,12,18 These antimicrobials can be used for the empiric treatment of suspected MRSA infections which are less severe, so that vancomycin and linezolid can be safeguarded against the development of bacterial resistance.…”

“…3,5,18 Susceptibility to clindamycin (79.5%), cotrimoxazole (73.5%), amikacin (68.7%) and rifampicin (90.4%) were high, similar to the observations reported in other studies. 5,12,18 These antimicrobials can be used for the empiric treatment of suspected MRSA infections which are less severe, so that vancomycin and linezolid can be safeguarded against the development of bacterial resistance. There was no significant difference in the susceptibility pattern between CA MRSA and HA MRSA, except for gentamicin.…”