A study of the reactions in non-sensitive skin of mixtures in vitro of reagin and atopen

Foran, Francis L.; Lichtenstein, M. R.

doi:10.1016/s0021-8707(31)90325-0

Cited by 13 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gay and Chant (13) first reported the finding of positive specific reactions. They have been supported by Foran and Lichtenstein (18) and Harley (5), and by our own findings previously (19) and now recorded. These contradictory reports may be due to the failure to discriminate between serum taken before and that taken during or after treatment, or they may be explained by the fact already mentioned that injection of heterologous serum into normal skin produced an irritative non-specific reaction with wheal and erythema readily confused with the specific reaction.…”

Section: The Reactions Of Serum-allergen Mixtures In Non-sensitive Tesupporting

confidence: 85%

Serological Evidence of Immunity With Coexisting Sensitization in a Type of Human Allergy (Hay Fever)

Cooke

Barnard

Hebald

et al. 1935

Journal of Experimental Medicine

395

154

View full text Add to dashboard Cite

Using ragweed hay fever as the representative of a certain type of allergy we have made studies to determine if possible the mechanism of the protection afforded by specific injections thus far established only by clinical observation. 1. Blood transfusions and serum injections from clinically immune, treated patients stopped the clinical reaction in untreated patients, thus indicating a transferable immunity. 2. The amount of skin sensitizing antibody in the serum was found to be practically unchanged by specific injections. 3. Injection of allergen-antibody mixtures into normal skin showed an immediate (1 hour) reaction when sites were made if serum of untreated cases (Serum A) was used but none or slight reaction if serum of treated cases (Serum P) was used. 4. When sites made with allergen-antibody mixtures were tested after 48 hours, reactions were absent with Serum A mixtures if enough allergen had been used, but were positive with mixtures of Serum P even though a much stronger allergen was contained in the mixture. 5. The primary inhibition of reactions with mixtures including Serum P was not due to antihistamine effect nor to binding of skin sensitizing antibody nor to binding or lysis of allergen. 6. The inhibiting antibody appears to be specific. 7. These serological studies supported by transfusion experiments have been interpreted by us as showing the development under treatment of a peculiar blocking or inhibiting type of immune antibody that prevented the action of allergen on the sensitizing antibody and hence showed in the type of human allergy under consideration (hay fever) the coexistence of sensitization and immunity.

show abstract

Section: The Reactions Of Serum-allergen Mixtures In Non-sensitive Tesupporting

confidence: 85%

Serological Evidence of Immunity With Coexisting Sensitization in a Type of Human Allergy (Hay Fever)

Cooke

Barnard

Hebald

et al. 1935

Journal of Experimental Medicine

395

154

View full text Add to dashboard Cite

show abstract

Section: The Reactions Of Serum-allergen Mixtures In Non-sensitive Tesupporting

confidence: 79%

“…Last dose given Nov. 17,1934. Serum P was taken Jan. 18,1935. 80 per cent relief (7 days hay fever).…”

Section: Methodsmentioning

confidence: 99%

Serological evidence of immunity with coexisting sensitization in a type of human allergy (hay fever)

1936

Journal of Allergy

View full text Add to dashboard Cite

Using ragweed h a y fever as an example of a type of allergy we record serological studies which were undertaken to explain the protection resulting from pollen injections. The results have indicated to us the production of an intfibiting or immune type of substance that prevented the allergen from reacting with the sensitized cell, and they have also demonstrated the coexistence of both sensitizing and immune antibodies in the specifically treated patients.

show abstract

Die Idiosynkrasien als allergische Krankheiten

Doerr

1944

Konstitution · Idiosynkrasien Stoffwechsel Und Ernährung

View full text Add to dashboard Cite

A study of the reactions in non-sensitive skin of mixtures in vitro of reagin and atopen

Cited by 13 publications

References 6 publications

Serological Evidence of Immunity With Coexisting Sensitization in a Type of Human Allergy (Hay Fever)

Serological Evidence of Immunity With Coexisting Sensitization in a Type of Human Allergy (Hay Fever)

Serological evidence of immunity with coexisting sensitization in a type of human allergy (hay fever)

Die Idiosynkrasien als allergische Krankheiten

Contact Info

Product

Resources

About