A study of the relationship between the Wnt/β-catenin signaling pathway and the gastrointestinal development of rat embryonic and perinatal periods

Abstract

The Wnt/β-catenin signaling pathway plays a critical role in directing cell fate during the embryonic development of animals and humans. To investigate the effects of the Wnt/β-catenin signaling pathway on gastrointestinal development and differentiation, we studied the expression pattern of β-catenin, a key component of the pathway, in the gastrointestinal tissues of embryonic and perinatal rats. Immunohistochemistry was used to examine the expression levels of β-catenin in Sprague Dawley (SD) rat embryos at days 13, 18 and 21 and in SD rats at 1, 3, 7 and 28 days of age. We observed that the expression of β-catenin was greater and more diffuse in the gastrointestinal tissues of rat embryos at days 18 and 21 of gestation and in SD rats at days 1 and 3. In conclusion, our data suggest that β-catenin also plays an important role in the development of gastrointestinal tissues during the middle and late embryonic periods and the early postnatal period.

Enhancement of delay eyelid conditioning by microcurrent electrical stimulation of the medial prefrontal cortex is triggered by the expression of Fos protein in guinea pigs

“…Kalmbach et al (13) used electrical stimulation of mossy fibers as a CS to investigate the interactions between the mPFC and cerebellum. CS in the central neural pathway perform more rapid enhancement of eyelid conditioning (27). The stimulated regions in the central nerve pathway CS include brain regions, such as lateral pons, where the signal from a traditional CS passes through, and the signal transduction pathway, including parallel fibers.…”