A study of the spectrum of psychotropic action of mebicar

Standard Volumetric Properties of Tetra-N-ethylglycoluril (Bicaret) in Ordinary and Heavy Water at Temperatures from (278.15 to 318.15) K and Ambient Pressure

“…The synthesized product was additionally purified by recrystallization from absolute ethanol and then dried for 24 h in vacuo at T = 320 K (to constant mass). The sample melting point, T mp , determined using the DSC heating curves 55 (see footnote f in Table 1) was (388.2 ± 0.5) K. This result is in good agreement with the previously reported values of T mp , being from 381 K to 384 K. 5,25,54 The molecular structure of the bicaret sample was confirmed by the results of 13 The deionized water was twice distilled (initially from a KMnO 4 dilute solution) up to a specific conductivity (κ) of 1.3 × 10 −6 S•cm −1 . Heavy water with κ = 1.2•10 −6 S•cm −1 was used as such (Table 1).…”

“…The psychotropic drugs mebicar (2,4,6,8-tetramethylglycoluril) and albicar (2,6-dimethyl-4,8-diethylglycoluril) are well-known tranquilizers and antidepressants. 4,13,15 Another known representative of the specified fully N-alkylated bioactive compounds, bicaret (2,4,6,8-tetraethylglycoluril), is much less studied. 16,21−23 Unlike most glycolurils including albicar, the conformationally similar mebicar and bicaret are achiral compounds due to symmetry of the alkyl-N-substituted positions in a molecule structure (Figure 1).…”

Standard Volumetric Properties of Chiral N-Methyl-Substituted Glycolurils in Water between 278.15 and 318.15 K at Ambient Pressure

“…Some of them were integrated into medicine or recommended for clinical practice. These include the highly efficient daytime tranquilizer Mebicar (an achiral N -tetramethylglycoluril) and the low-toxic anxiolytic drug Albicar (a chiral trans- coordinated N -dimethyldiethylglycoluril). − …”

Standard molar volumes and expansibilities of 1,3-alkyl-N-substituted achiral glycolurils in water at T=(278.15 to 318.15)K and p=0.1MPa: A comparative analysis

“…In last two decades, the widespread interest in glycolurils has led to a variety of alkyl-N-derivatives, which used either as the physiologically active low-toxic pharmaceuticals or as the precursors in their synthesis [9][10][11][12]. A well-known representative of such drugs is the mebicar (1,3,4,6-tetramethylglycoluril) that used as a day-time tranquilizer since late 1970-s [13,14]. Another perspective high-efficient psychotropically active compounds are the albicar (1,4-diethyl-3,6-dimethylglycoluril) and the bicaret (1,3,4,6-tetraet hylglycoluril) [15][16][17][18].…”