A Study of Thyroid Dysfunction in Type 2 Diabetes Mellitus in Tertiary Care Center

Abstract

Introduction: Type 2 diabetes mellitus and thyroid disorders are the most common endocrine disorders and growing problem in our country. We have observed that many diabetes mellitus patients are associated with thyroid dysfunction. However, the prevalence of thyroid dysfunction in these patients has not been investigated. We conducted this study to study the proportion of Thyroid dysfunction in patients with type 2 Diabetes. Materials and methods: The current study was a prospective, cross-sectional study. All the type-2 Diabetic patients and normal subjects with no diabetes attended to the outpatient clinic and admitted in the General Medicine department at Kasturba hospital, Manipal was considered as the study population. After obtaining informed written consent, a structured questionnaire was used to analyse the patient's chief complaints, General and local examination was performed by measuring BMI, waist circumference. Lab investigations were recorded. Analysis based on patient's lab values for FBS, PPBS, HbA1C AND TSH, LIPID PROFILE. Results: The mean age of subjects in cases was 55.98 ± 11.19 years and it was 54.54 ± 10.08 years in controls. The difference in the proportion of gender between study groups was statistically not significant, the difference in weight and BMI between the two groups was statistically significant. There was no statistically significant difference in cholesterol, triglyceride, LDL between two groups. The difference in the proportion of thyroid dysfunction between the two groups was statistically significant. Conclusion: The present study showed a high prevalence of thyroid dysfunctions in patients of type 2 DM.

A Study on the Prevalence of Thyroid Dysfunction in Patients With Type 2 Diabetes Mellitus in a Tertiary Centre in a Tribal Population of Eastern India

“…Subclinical hypothyroidism was the most prevalent thyroid dysfunction in diabetic patients in our study, similar to the line of the Reddy et al study [16]. Subclinical hypothyroid was the earliest and most common thyroid dysfunction in all age groups, in both males and females.…”

“…The average age of the diabetes patient in our study was 51.89+12 16. y, similar to Jinaga Satyanarayan Rao, et al, in which the mean age was 53.89±11.61 y [8].…”

“…In hypothyroidism, there is a reduction in glucose-induced insulin secretion by beta cells, and the response of beta cells to glucose or catecholamine is increased in hyperthyroidism due to increased beta cell mass. Moreover, insulin clearance is increased in thyrotoxicosis [16]. The half-life of insulin is reduced in a thyrotoxic environment; this is thought to be due to increased degradation of the active hormone and the release of inactive precursors [17].…”