A study of Toxoplasma and Cytomegalovirus serology in tuberculosis and in HIV-infected patients in Burkina Faso

Ledru, Éric; Diagbouga, Serge; Ledru, Sylvie; Cauchoix, B.; Yameogo, Mathias; Chami, D.; Sanou, Oumarou; Chiron, J.P.

doi:10.1016/0001-706x(95)00073-n

Cited by 21 publications

(7 citation statements)

References 13 publications

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“…Seroprevalence of anti-CMV IgG was 100% among our HIV-infected cohort. This is in agreement with report from the Lagos University Teaching Hospital, south west Nigeria and Burkina Faso by Akinbami et al [10] at and Ledru et al [11] respectively that documented a prevalence of anti-CMV IgG antibody of 100% among HIV-infected patients. [12] reported a lower seroprevalence of 59.2% in Ghana.…”

Section: Discussionsupporting

confidence: 93%

Seroprevalence of and Risk Factors for Cytomegalovirus among HIV-Infected Patients at University of Maiduguri Teaching Hospital, Nigeria

Kida¹,

Denue²,

Bakki³

et al. 2014

OJI

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Although the distribution of cytomegalovirus (CMV) infection has a wide regional variation, it is more common in Africa and Asia with high prevalence approaching 100% in some communities. CMV is a frequent opportunistic infection and major cause of morbidity and mortality among HIV patients with severe immunosuppression. It can be contracted from body fluid, including saliva, urine, blood, cervical secretions, and semen. CMV seropositivity is considered the best laboratory measure of past infection. We determined the prevalence of CMV and the risk factors associated with its acquisition in a population of HIV positive patients. Anti-CMV IgG seroprevalence was 100% among HIV infected subjects and 98.6% among controls. Having multiple sexual partners and traditional practices were identified as risk factors associated with risk of contracting CMV infection.

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Section: Discussionsupporting

confidence: 93%

Seroprevalence of and Risk Factors for Cytomegalovirus among HIV-Infected Patients at University of Maiduguri Teaching Hospital, Nigeria

Kida¹,

Denue²,

Bakki³

et al. 2014

OJI

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“…In fact, Pneumocystis carinii pneumonia could not be routinely diagnosed at the time of the study, and cerebral toxoplasmosis was only diagnosed in 5.8% of C stage patients. This low percentage is in contrast with the high seroprevalence for toxoplasmosis (close to 60%) in adults living in BoboDioulasso 21 . In addition, P. carinii pneumonia and cerebral toxoplasmosis were diagnosed in 4% and 21% of patients dying with AIDS in Ivory Coast, respectively 4 .…”

mentioning

confidence: 65%

A proposal for basic management of HIV disease in West Africa: use of clinical staging and haemogram data

Ledru¹,

Diagbouga²,

Méda³

et al. 1998

Int J STD AIDS

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Our objective was to propose a strategy to screen HIV-infected African people for biological immunodeficiency easily. In a cross-sectional study, we analysed the patterns of diseases and of CD4 counts among 266 HIV-infected adults. Peripheral facial paralysis and chronic cutaneo-mucous diseases were the earlier B-stage diseases. Pulmonary tuberculosis was close to B-stage diseases, and chronic diarrhoea was borderline between B and C stages. Cachexia was the most frequent C-stage symptom (47.8%). Ninety per cent of CDC-C stage people had CD4 counts below 350/microliter, whereas only 75% had CD4 counts below 200/microliter. Regression analysis identified the lymphocyte count, clinical stage and platelet count as predictors of CD4 count below 350/microliter. A simple score (lymphocyte count < or = 2500/microliter and clinical stage > or = B) is proposed to determine this CD4 threshold (positive predictive value: 83%) and to determine those patients needing treatment to prevent wasting and opportunistic infections.

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“…The fact that the increase in antibody responses to heterologous pathogens was most evident in APTB disease may mean that this non-specific effect is most pronounced in a milieu of actively replicating tubercle bacilli. Indeed, previous research has shown that active TB disease is associated with increases in cytomegalovirus-specific antibodies (21,22), however, these studies attributed the rise in antibodies to concurrent infection with CMV rather than as a marker of serological memory. A study by de Paus and colleagues (2013) observed higher levels of influenza-specific antibodies in individuals with TB and recognized that in addition to concurrent infection there was a possibility that these may have arisen as a result of mycobacterial driven non-specific increases in antibodies.…”

Section: Discussionmentioning

confidence: 93%

Mycobacterium tuberculosisinfection boosts B cell responses to unrelated pathogens

Kimuda

Andia-Biraro

Sebina

et al. 2019

Preprint

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Significance 42Mycobacterium tuberculosis (M.tb) has potent immunostimulatory properties and has been used in 43 adjuvant preparations to improve vaccine responses in animals. This study shows that natural M.tb 44 infection in humans is associated with increased antibody and B cell recall responses to heterologous 45 pathogens. This data suggests a potential role for M.tb antigens in immunotherapies designed to 46 maintain antibody immunity to diverse infections. 47

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A study of Toxoplasma and Cytomegalovirus serology in tuberculosis and in HIV-infected patients in Burkina Faso

Cited by 21 publications

References 13 publications

Seroprevalence of and Risk Factors for Cytomegalovirus among HIV-Infected Patients at University of Maiduguri Teaching Hospital, Nigeria

Seroprevalence of and Risk Factors for Cytomegalovirus among HIV-Infected Patients at University of Maiduguri Teaching Hospital, Nigeria

A proposal for basic management of HIV disease in West Africa: use of clinical staging and haemogram data

Mycobacterium tuberculosisinfection boosts B cell responses to unrelated pathogens

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